A5022550691- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Molecular Biology Techniques and Applications
- Archaeology and ancient environmental studies
- PI3K/AKT/mTOR signaling in cancer
- Race, Genetics, and Society
- Iron Metabolism and Disorders
- Genetic diversity and population structure
- Hemoglobinopathies and Related Disorders
- Archaeological and Historical Studies
- Chronic Lymphocytic Leukemia Research
- Paleopathology and ancient diseases
- Folate and B Vitamins Research
- Aging, Health, and Disability
- Genetic Associations and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Bacillus and Francisella bacterial research
- Medicine and Dermatology Studies History
- Monoclonal and Polyclonal Antibodies Research
- Pharmacogenetics and Drug Metabolism
- Trace Elements in Health
- Health and Lifestyle Studies
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Molecular Research
- Lung Cancer Treatments and Mutations
Universidad Complutense de Madrid
2015-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2019-2025
Advanced Neural Dynamics (United States)
2023
Hospital Clínico San Carlos
2023
Dalhousie University
2021
Politecnica Salesiana University
2016-2020
Escuela Colombiana de Rehabilitación
2019
Pedagogical and Technological University of Colombia
2018
Instituto Nacional de Toxicología y Ciencias Forenses
2017
Hospital Universitario de Maracaibo
2012-2014
Many studies of human populations have used the male-specific region Y chromosome (MSY) as a marker, but MSY sequence variants traditionally been subject to ascertainment bias. Also, dating haplogroups has relied on Y-specific short tandem repeats (STRs), involving problems mutation rate choice, and possible long-term saturation. Next-generation sequencing can ascertain single nucleotide polymorphisms (SNPs) in an unbiased way, leading phylogenies which branch-lengths are proportional time,...
Numerous studies of human populations in Europe and Asia have revealed a concordance between their extant genetic structure the prevailing regional pattern geography language. For native South Americans, however, such evidence has been lacking so far. Therefore, we examined relationship Y-chromosomal genotype on one hand, male geographic origin linguistic affiliation other, largest study American natives to date terms sampled individuals populations. A total 1,011 individuals, representing...
Abstract Since 2011, with the approval of crizotinib and subsequent four additional targeted therapies, anaplastic lymphoma kinase (ALK) inhibitors have become important treatments for a subset patients lung cancer. Each generation ALK inhibitor showed improvements in terms central nervous system (CNS) penetration potency against wild-type (WT) ALK, yet key continued limitation is their susceptibility to resistance from active-site mutations. The solvent front mutation (G1202R) gatekeeper...
Abstract The proportion of Europeans descending from Neolithic farmers ∼10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. male-specific region the Y chromosome (MSY) widely applied to this question, but unbiased estimates diversity and time depth have lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing 3.7 Mb MSY DNA in 334 males, comprising 17 Middle Eastern populations, defines phylogeny containing...
Poor diet quality and obesity, especially abdominal have been associated with systemic inflammation. The neutrophil-to-lymphocyte Ratio (NLR) is an available inexpensive inflammation biomarker. aim of the present study was to determine association dietary patterns obesity inflammatory state. A group 1747 Spanish noninstitutionalized older adults individuals were included, a food-frequency questionnaire applied. Global Food Score (GFS) Healthy Eating Index for population (SHEI) calculated....
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, PDCD4) the eIF4F complex. Activation has a direct role tumorigenesis due increased synthesis oncogenes that are dependent on enhanced RNA helicase activity for translation. eFT226, which inhibits translation specific mRNAs by promoting eIF4A1 binding 5'-untranslated regions (UTR) containing polypurine...
Abstract Ancient mtDNA was succesfully recovered from 24 skeletal samples of a total 60 ancient individuals Patagonia‐Tierra del Fuego, dated to 100–400 years BP, for which consistent amplifications and two‐strand sequences were obtained. Y‐chromosome STRs (DYS434, DYS437, DYS439, DYS393, DYS391, DYS390, DYS19, DYS389I, DYS389II, DYS388) the biallelic system DYS199 also amplified, Y‐STR alleles could be characterized in nine cases, with an average 4.1 loci per sample correctly typed. In two...
The aim of this study was to investigate the combined influence diet, menstruation and genetic factors on iron status in Spanish menstruating women (n = 142). Dietary intake assessed by a 72-h detailed dietary report menstrual blood loss questionnaire, determine Menstrual Blood Loss Coefficient (MBLC). Five selected SNPs were genotyped: rs3811647, rs1799852 (Tf gene); rs1375515 (CACNA2D3 rs1800562 rs1799945 (HFE gene, mutations C282Y H63D, respectively). Iron biomarkers determined cluster...
Background: In prehistoric societies, especially in the Neolithic period, study of palaeodiet assumes special importance as it is one points human history characterised by important changes diet. this context, food intolerances even more significant. Methods: Some individuals studied were analysed from a genetic point view, while systematic literature review was performed perspective, verifying persistence or absence lactase adulthood, and information necropolises regarding presence...
DNA transfer caused by the use of a washing machine is topic great importance in forensic field, as it can have significant implications collecting genetic evidence at crime scenes. Understanding during process important since this affect accuracy and reliability recovered samples. In study, two experiments were carried out on 53 volunteers, one studied touch other blood DNA. Fabrics washed with clean acceptor fabric machine. Mixtures alleles obtained, especially fabrics, partially matching...
Abstract Background Iron deficiency anaemia is a worldwide health problem in which environmental, physiologic and genetic factors play important roles. The associations between iron status biomarkers single nucleotide polymorphisms (SNPs) known to be related metabolism were studied menstruating women. Methods A group of 270 Caucasian women, population at risk anaemia, participated the study. Haematological biochemical parameters analysed 10 selected SNPs genotyped by minisequencing assay....
The male-mediated genetic legacy of the Pyrenean population was assessed through analysis 12 Y-STR and 27 Y-SNP loci in a sample 169 males from 5 main geographical areas Spanish Pyrenees: Cinco Villas (Western Pyrenees), Jacetania Valle de Arán (Central Pyrenees) Alto Urgel Cerdaña (Eastern Pyrenees). In Iberian context, samples present some specificities, being characterizeded by high proportion chromosomes R1b1b2-M269 (including usually uncommon R1b1b2d-SRY(2627) R1b1b2c-M153 types) or...
Abstract Anaplastic lymphoma kinase (ALK) gene rearrangements occur in up to 7% of patients with non-small cell lung cancer (NSCLC) the majority as EML4-ALK fusions. Crizotinib (first generation ALK inhibitor) was first approved inhibitor for treatment ALK-positive metastatic cancer. However, development resistance crizotinib caused by secondary domain mutations, bypass signaling, or morphology changes occurs. Second inhibitors alectinib, ceritinib, and brigatinib were able overcome...