A5100447042- Cervical Cancer and HPV Research
- Genital Health and Disease
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Colorectal and Anal Carcinomas
- Cannabis and Cannabinoid Research
- Plant-based Medicinal Research
- Ginger and Zingiberaceae research
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Sepsis Diagnosis and Treatment
- Healthcare and Venom Research
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Reproductive Biology and Fertility
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Neurological Disease Mechanisms and Treatments
- Ethnobotanical and Medicinal Plants Studies
- Adipose Tissue and Metabolism
- Gestational Trophoblastic Disease Studies
- Polysaccharides and Plant Cell Walls
- Prenatal Screening and Diagnostics
- Medicinal Plant Pharmacodynamics Research
Northwest Women's and Children's Hospital
2023-2025
Bozhou People's Hospital
2022-2024
Anhui Medical University
2022-2024
Women's Hospital, School of Medicine, Zhejiang University
2014-2024
Shanghai East Hospital
2024
Southern Medical University
2021-2024
Nanfang Hospital
2021-2024
Shaanxi University of Chinese Medicine
2020-2024
Qingdao University
2016-2023
Jiangxi University of Traditional Chinese Medicine
2022-2023
Abstract Background Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar ferroptosis, a novel form of cell death. However, whether DHA causes ferroptosis in glioma cells and the potential regulatory mechanisms remain unclear. Methods Effects on proliferation, death, ROS lipid generation as well reduced gluthione consumption were assessed with or without inhibitor. The biological by attenuate...
Obesity and related metabolic diseases associated with chronic low-grade inflammation greatly compromise human health. Previous observations on the roles of interferon regulatory factors (IRFs) in regulation metabolism prompted investigation involvement a key family member, IRF3, disorders. IRF3 expression liver is decreased animals diet-induced genetic obesity. The global knockout (KO) significantly promotes high-fat diet (HFD)-induced hepatic insulin resistance steatosis; contrast,...
The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the detailed mechanism is unclear. In this study, we investigated interactive effects of on ovarian cisplatin resistance to explore potential therapeutic targets. Methods: An inducible mutants active in either MAPK/ERK (S35 E38) or PI3K/AKT (C40) both (V12) were sequentially introduced into a p53-null cell line-SKOV3. Comparative microarray analysis was performed using Gene Chip Prime View Human Expression...
Abstract Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we that advanced oxidation protein products (AOPPs) plasma were elevated women with POI and had an adverse effect on granulosa cell proliferation. However, mechanism underlying effects AOPPs autophagy-lysosome pathway regulation cells remains unclear. In this study, autophagy lysosomal biogenesis mechanisms explored by a series vitro...
Older adults have been reported to be a population with high-risk of death in the COVID-19 outbreak. Rapid detection patients is crucial reduce mortality this population. The aim study was evaluate prognositc accuracy Modified Early Warning Score (MEWS) for in-hospital older COVID-19.A retrospective cohort conducted Wuhan Hankou Hospital China from 1 January 2020 29 February 2020. Receiver operating characteristic (ROC) analysis used predictive value MEWS, Acute Physiology and Chronic Health...
Patients with multiple sclerosis (MS) commonly exhibit cognitive impairments (CI). However, the neural mechanisms underlying CI remain unclear. The current study applied diffusion tensor imaging (DTI) and voxel-based morphometric (VBM) magnetic resonance (MRI) techniques to evaluate differences in white matter (WM) integrity gray (GM) volume between MS patients preservation (CP). Neuropsychological assessment MRI were obtained from 39 relapsing-remitting (RRMS) 29 healthy controls (HCs)....
Valerian volatile oil can be used in the treatment of insomnia; however, active components and mechanisms action are currently unclear. Therefore, we transcriptome sequencing weight coefficient network pharmacology to predict effective mechanism valerian an insomnia model induced by intraperitoneal injection para-Chlorophenylalanine (PCPA) SD rats. essential was given orally for contents 5-hydroxytryptamine receptor 1 A (5-HT1AR), γ-aminobutyric acid (GABA), cyclic adenosine monophosphate...
Monoacylglycerol lipase (MAGL) is the principle enzyme for metabolizing endogenous cannabinoid ligand 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG levels, resulting in subsequent activation endocannabinoid system, and has emerged as a novel therapeutic strategy to treat drug addiction, inflammation, neurodegenerative diseases. Herein we report new series inhibitors, which were radiolabeled by site-specific labeling technologies, including
Exercise improves cognitive function in older adults, but the underlying mechanism is largely unknown. Both lysosomal degradation and mitochondrial quality control decline with age. We hypothesized that exercise ameliorates age-related through improvement of aged hippocampus, this effect associated proteolysis. Sixteen to eighteen-month old male Sprague Dawley rats underwent swim training for 10 weeks. The regimen prevented rats, reduced oxidative stress, rejuvenated mitochondria...
Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as potential therapeutic approach for treatment diverse pathological conditions, including chronic pain, inflammation, cancer, and neurodegeneration. Herein, we disclose novel array reversible irreversible inhibitors by means "tail switching" on piperazinyl azetidine scaffold. We developed lead irreversible-binding...
The Citrus aurantium- (ZhiShi, ZS-) Rhizoma Atractylodis Macrocephalae (BaiZhu, BZ) pairs are often found in herbal formulas for constipation. volatile oils of ZS and BZ (ZBVO) have good pharmacological activity against constipation, but the mechanism treatment slow transit constipation (STC) remains unclear. A rat model using diphenoxylate tablets was constructed to investigate if transdermal administration ZBVO would mediate intestinal microorganisms fecal metabolites improve STC symptoms....
Scavenging of oxidative stress by antioxidants may provide a therapeutic strategy for nonalcoholic fatty liver disease (NAFLD). Increasing evidence is supporting the potential application natural resourced polysaccharides as promising prevention or treatment strategies against NAFLD. In current study, an acidic heteropolysaccharide, LFP‐a1, was isolated and purified from Lycii fructus with successively hot water refluxing extraction, alcohol precipitation, protein removal, DEAE‐52 cellulose...
Bisphenol A (BPA) is a typical endocrine-disrupting chemical (EDC) used worldwide. Considering its adverse effects, BPA has been banned or strictly restricted in some nations, and many analogs have introduced to the market. In this study, we selected three representative substitutes, BPS, BPF, BPAF, along with BPA, assess developmental reproductive effects on Daphnia magna. The F0 generation was exposed bisphenols (BPs) at an environmentally relevant concentration (100 μg/L) for 21 d; then...
Objective: To investigate the effects and mechanisms of Paeoniae radix rubra–Angelicae sinensis (P-A) drug pair in treatment rheumatoid arthritis (RA). Methods: Mass spectrometry was employed to accurately characterize main components P-A pair. Network pharmacology used analyze pathways RA, Discovery Studio software molecularly dock key proteins on pathway with their corresponding compounds. The levels serum TNF-a, IL-1β, IL-6 were measured by enzyme linked immunosorbent assay (ELISA)....
<title>Abstract</title> Osteoporosis is the most common form of bone disease and RANKL/RANK/OPG has been widely demonstrated to be a critical protein for metabolism. Previous studies suggested that flavonoids played an obligatory role in inhibition process osteoclast differentiation induced by RANKL. However, detailed mechanisms were still unknown. Eucommia ulmoides popular herb used treat diseases traditional medicine, which play important role. Thus, present study, specially selected...
Abstract By numerical propagation of the coupled Gross-Pitaevskii equations, ground state phase a SU(3) spin-orbit Bose gas with nonlocal soft-core interactions has been investigated within all parameter space, showing strong dependence on strength coupling, interactions, spin-exchange and Rydberg blockade radius. More specially, we also perform detailed study interaction radius at point rotational symmetry breaking. Our results show that under combined effects such parameters, shows...
Osteoporosis, characterized by excessive osteoclast activation, is mediated through the RANKL/RANK/OPG signaling axis. While flavonoids from Eucommia ulmoides (EU) have demonstrated anti-osteoclastogenic activity, their atomic-level mechanisms remain elusive. Here, we investigated six EU-derived (cyrtominetin, quercetin, syringetin, genistein, ombuin, and kaempferol) targeting RANKL using integrated computational approaches. Molecular docking revealed strong binding affinities (Total_Score >...
Carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl-N-methylcarbamate), a broad spectrum N-methyl carbamate insecticide, and its metabolite, 3-hydroxycarbofuran, exert their toxicity by reversibly inhibiting acetylcholinesterase (AChE). To characterize AChE inhibition from carbofuran exposure, physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model was developed in the Exposure-Related Dose Estimating Model (ERDEM) platform for Sprague-Dawley (SD) rat. Experimental estimates of...