A5068436566- Oral microbiology and periodontitis research
- Flood Risk Assessment and Management
- Immune Response and Inflammation
- Hydrology and Watershed Management Studies
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Hydrology and Drought Analysis
- Advanced Photocatalysis Techniques
- Psoriasis: Treatment and Pathogenesis
- Endoplasmic Reticulum Stress and Disease
- Immunodeficiency and Autoimmune Disorders
- NF-κB Signaling Pathways
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- Oral Health Pathology and Treatment
- Immune cells in cancer
- Inflammasome and immune disorders
- Hydrological Forecasting Using AI
- Covalent Organic Framework Applications
- Proteoglycans and glycosaminoglycans research
- Bone and Dental Protein Studies
- Orthodontics and Dentofacial Orthopedics
- Advanced Nanomaterials in Catalysis
- Data Mining Algorithms and Applications
- Infrastructure Resilience and Vulnerability Analysis
Nanjing Hydraulic Research Institute
2021-2024
Hohai University
2024
Sun Yat-sen University
2014-2024
Hospital of Stomatology, Sun Yat-sen University
2012-2024
Stomatology Hospital
2012-2023
Tianjin University
2021-2022
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2021
Henan University
2017
University of Minnesota
2016
University of Minnesota Medical Center
2016
Aberrant activation of inflammation and excess accumulation lipids play crucial role in the occurrence progression atherosclerosis (AS). Quercetin (QCT) has been tested effectively to cure AS. It is widely distributed plant foods proved have potential antioxidative anticancer activities. However, underlying molecular mechanisms OCT AS are not completely understood. In present study, we stimulated murine RAW264.7 cells with lipopolysaccharide (LPS) or oxidized low-density lipoproteins...
Hepatocellular carcinoma (HCC) is a hypervascular tumor and accumulating evidence suggests that angiogenesis plays an important role in HCC development. Cordycepin, also known as 3'-deoxyadenosine, derivative of adenosine, numerous cellular enzymes cannot differentiate the two. The aim present study was to determine whether cordycepin regulates proliferation, migration human umbilical vein endothelial cell line (EA.hy926) hepatocellular (HepG2). MTT used assess proliferation. Apoptosis...
Pseudomonas aeruginosa (P. aeruginosa) is a serious zoonotic pathogen threaten the poultry industry causing severe economic losses therefor, this study aimed to isolation, phenotypic, molecular identification of P. from different avian sources (chickens, turkey, pigeons, table eggs and dead in shell chicken embryos), Egyptian governorates (Giza, Qalubia, Beheira, El- Minya Al-Sharqia) with applying antibiotic sensitivity test on all isolates. Highly resistant isolates (n=49) were subjected...
In this study, we investigated the promoter DNA methylation (DNAm) status of MMP-9 and TIMP-1 genes in patients with chronic periodontitis to evaluate disease progression. Using pyrosequencing technology, DNAm levels CpG islands were measured 88 15 healthy controls. We found a positive correlation between severity periodontitis. Methylated also closely associated duration Moreover, female exhibited lower but higher compared male patients, gradually decreased age. The findings gender...
// Sarrabeth Stone 1, 2, 3, * , Yeung Ho Xiting Li 4 Stephanie Jamison 3 Heather P. Harding 5 David Ron Wensheng Lin 1 Department of Neuroscience, University Minnesota, Minneapolis, United States 2 Institute for Translational Masonic Cancer Center, Periodontics, Guanghua School Stomatology, Hospital Sun Yat-sen University, Guangzhou, Guangdong, China Cambridge Medical Research, Cambridge, Kingdom These authors contributed equally to this work Correspondence to: Lin, email: linw@umn.edu...
Interleukin-22 (IL-22) exerts extensive biological effects, playing both protective and pathological roles in autoimmune infectious diseases. However, the specific role mechanism of IL-22 pathogenesis periodontitis have not been clarified. The aim this study was to analyze possible osteoclastogenesis osteogenesis periodontitis.Human periodontal ligament fibroblasts (hPDLFs) were treated with and/or lipopolysaccharide from Porphyromonas gingivalis (Pg-LPS), mRNA protein expression RANKL OPG...
Porphyromonas gingivalis, as a major pathogen of periodontitis, could rapidly adhere to and invade host gingival epithelial cells (GECs) for the induction infection. One ATP-binding cassette (ABC) transporter gene was found be upregulated during this infection process, however, molecular mechanisms remain unclear. In study, we systemically investigated messenger RNA level changes all ABC family genes in P. gingivalis while being internalized within GECs by real-time polymerase chain...
Flood disaster is one of the critical threats to cities. With intellectualization tendency Industry 4.0, refined urban flood models can effectively reproduce inundation scenarios and support decision-making on response flood. However, spatiotemporal variability rainfall spatial heterogeneity surface greatly increase uncertainties in simulations. Therefore, it crucial account for events grids model as accurately possible avoid misleading simulation results. This study aims investigate effect...
Abstract Adjacent mountain area and plain generally belong to the same climate zone, a close hydraulic connection is also found between them. However, flood controls in these two areas different management departments. Flood occurring can bring serious waterlog disasters, posing great threat human lives property. Previous studies mainly focused on individual event or areas, while research floods simultaneously both insufficient. Hence, this study establishes copula function-based assessment...
Parkinson's disease (PD) is the second most common neurodegenerative disorder globally that lacks any disease-modifying drug for prevention or treatment. Oxidative stress has been identified as one of key pathogenic drivers (PD). Edaravone, an approved free-radical scavenger, proven to have potential against PD by targeting multiple pathologies, including oxidative stress, focal mitochondria, and neuroinflammation. However, its bioavailability potentially restricted due poor solubility short...
To investigate the effect and mechanism of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on Th17 cell differentiation mediated by CD14+ monocytes.P. LPS-activated monocytes were co-cultured with CD4+T cells in different ratios. An indirect co-culture system was also established using transwell chambers. Furthermore, anti- Delta-like ligand 4 (Dll-4) antibody used to role Dll-4 response. The mRNA expression analyzed quantitative reverse transcription-polymerase chain...
The immune response mediated by Th17 cells is essential in the pathogenesis of periodontitis. Emerging evidence has demonstrated that lipopolysaccharide from Porphyromonas gingivalis (Pg-LPS) could promote Th17-cell differentiation directly, while downstream signaling remains elusive. This study was aimed to explore role JMJD3 (a JmjC family histone demethylase) and signal transducers activators transcription 3 (STAT3) triggered Pg-LPS clarify interaction between them. We found expression...
With the completion of whole genome sequence for many organisms, investigations into genomic structure have revealed that gene distribution is variable, and genes with similar function or expression are located within clusters. This clustering suggests there evolutionary constraints determine architecture. However, as most evidence on evolution comes from studies yeast, it unclear how much this prior work can be extrapolated to mammalian genomes. Therefore, in we wished examine regions...
The Porphyromonas gingivalis bacterium is one of the most influential pathogens in oral infections. In current study, antimicrobial activity α-amylase and pentamidine against was evaluated. Their vitro inhibitory investigated with agar overlay technique, minimal bactericidal concentrations were determined. Using concentration, actions inhibitors investigated. present multiple techniques utilized, including scanning electron microscopy (SEM), general structural analysis differential gene...