A5025007803- Effects and risks of endocrine disrupting chemicals
- Plant Stress Responses and Tolerance
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Plant nutrient uptake and metabolism
- Arsenic contamination and mitigation
- Plant Micronutrient Interactions and Effects
- Estrogen and related hormone effects
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Toxic Organic Pollutants Impact
- RNA modifications and cancer
- Ammonia Synthesis and Nitrogen Reduction
- 14-3-3 protein interactions
- Developmental Biology and Gene Regulation
- Hydrogen Storage and Materials
- Muon and positron interactions and applications
- Medicinal Plant Pharmacodynamics Research
- Caveolin-1 and cellular processes
- Hedgehog Signaling Pathway Studies
Ningbo University
2011-2024
Huazhong Agricultural University
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2023
Wenzhou Medical University
2012-2022
Affiliated Eye Hospital of Wenzhou Medical College
2013-2022
China West Normal University
2021
State Key Laboratory of Ophthalmology
2018
Kunming University of Science and Technology
2018
Ningbo Academy of Agricultural Sciences
2014-2017
Huazhong University of Science and Technology
2014
Histone methylation is a dynamic process that participates in diverse array of cellular processes and has been found to associate with cancer. Recently, several histone demethylases have identified catalyze the removal from H3 lysine residues. Through bioinformatic biochemical analysis, we JARID1B as H3K4 demethylase. Overexpression resulted loss tri-, di-, monomethyl but did not affect other methylations. In vitro experiments demonstrated directly catalyzes demethylation. The enzymatic...
Objective Hypoadiponectinemia contributes to the development of obesity and related disorders such as diabetes, hyperlipidemia, cardiovascular diseases. In this study we investigated effects green tea polyphenols (GTPs) on adiponectin levels fat deposits in high (HF) fed rats, mechanism signaling pathway was explored well. Methods Results Male Wistar rats were with high-fat diet. GTPs (0.8, 1.6, 3.2 g/L) administered via drinking water. Serum insulin measured by ELISA, mRNA PPARγ visceral...
Epithelial-mesenchymal transition (EMT) is a physiological process that has been recognized to occur during the progression of an increasingly large number human diseases, including liver fibrosis, cirrhosis, and hepatocellular carcinoma. The activation transforming growth factor β (TGF-β) signaling considered critical event EMT, efforts have made screen small molecules interfere with TGF-β pathway EMT. Here we report identification sorafenib, clinical agent inhibits signaling. When applied...
Novel furoxan-based nitric oxide (NO) releasing derivatives (8a-p) of farnesylthiosalicylic acid (FTS) were synthesized. Compound 8l displayed the strongest inhibition on proliferation human hepatocellular carcinoma (HCC) cells in vitro, superior to FTS, sorafenib, and furoxan moiety, selectively induced high frequency HCC cell apoptosis, produced levels NO but not nontumor liver cells. Furthermore, exhibited low acute toxicity mice significantly inhibited growth tumors vivo Ras-related...
Epidemiological findings on the association between bisphenol A (BPA, 2,2- bis -(4-hydroxyphenyl)propane) exposure and type 2 diabetes mellitus (T2DM) are paradoxical. In animal studies, BPA has been shown to disrupt pancreatic function blood glucose homeostasis even at a reference ‘safe’ level during perinatal period. this study, we explored effects of long-term paternal parents themselves their offspring. Adult male genitor rats fed with either standard chow diet (STD) or high-fat (HFD)...
Defective lipid metabolism is associated with increased risk of various chronic diseases, such as obesity, cardiovascular and diabetes. Resveratrol (RSV), a natural polyphenol, has been shown the potential ameliorating disregulations metabolism. The objective this study was to investigate effects feed intake RSV on in zebrafish (Danio rerio). adult males were randomly allocated 6 groups: control (Con, 8 mg cysts/fish/day), 20 μmol/L (Con+RSV), calorie restriction (CR, 5 (CR+RSV), overfeed...
Primary renal lymphoma (PRL) is a rare disease, with no more than 70 cases reported in the literature. The present study reports case of 70‑year‑old woman PRL. patient was asymptomatic, however, mass on right kidney identified incidentally during routine physical examination. Computed tomography revealed that 3.6 cm diameter. Subsequently, nephrectomy performed. histological evaluation specimen showed diffuse large B‑cell non‑Hodgkin's lymphoma. treated 6-8 cycles cyclophosphamide,...
In order to improve the delivery efficiency of microRNA (miRNA or miR)-145, present study examined several factors which may affect cationic liposome (CL)-based transfection, including hydration medium used for preparation liposomes, quantity plasmid, molar ratio N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTAP)/cholesterol (chol), DOTAP/chol, and weight DOTAP/DNA. enhance transfection efficiency, protamine was selected as a DNA-condensing agent form...
Abstract Leaf growth relies on photosynthesis and hydraulics to provide carbohydrates expansion power; in turn, leaves intercept light construct organism systems for functioning. Under potassium (K) deficiency stress, leaf area, are all affected by alterations structure. However, the connection between changes function caused structure under K regulation is unclear. Consequently, hydraulic conductance ( ) photosynthetic rate A combined with anatomical characteristics of Brassica napus were...
Hyperglycemia-induced endothelial hyperpermeability is crucial to cardiovascular disorders and macro-vascular complications in diabetes mellitus. The objective of this study investigate the effects green tea polyphenols (GTPs) on role nicotinamide adenine dinucleotide phosphate (NADPH) pathway. Male Wistar rats fed a high fat diet (HF) were treated with GTPs (0, 0.8, 1.6, 3.2 g/L drinking water) for 26 weeks. Bovine aortic cells (BAECs) glucose (HG, 33 mmol/L) (0.0, 0.4, or 4 μg/mL) 24 hours...
Background: The expression of acetylcholinesterase (AChE) could be induced during apoptosis in various cell types.And reduced AChE either by siRNA prevent apoptosis.However, the detailed mechanisms underlying regulation are largely unknown human breast cancer cell.Material and methods: MCF-7 cells were cultured treated cisplatin absence or presence p53 siRNA.Results: In this study, cisplatin, a current used anticancer drug, was investigated line MCF-7.Exposure to resulted time-and...
This study explored the potential value of curcumin, a natural product, in protection CsA‑induced nephrotoxicity. The aim present was to investigate effects curcumin on Cyclosporine A (CsA)‑induced renal oxidative stress and determine underlying molecular mechanisms protective Cur. HK‑2 human cells were co‑treated with CsA various doses Cell survival rate determined by an MTT assay, total cellular protein collected cell homogenates evaluated determining activity superoxide dismutase (SOD),...
SUMMARY Crop photosynthesis ( A ) and productivity are often limited by a combination of nutrient stresses, such that changes in the availability one may affect another nutrient, turn influencing . In this study, we examined synergistic effects phosphorus (P) potassium (K) on leaf amendment experiment, which P K were added individually or to Brassica napus grown under co‐limitation. The data revealed addition gradually removed dominant limiting factor (i.e. P) improved Strikingly,...
SUMMARY Plants grown under low magnesium (Mg) soils are highly susceptible to encountering light intensities that exceed the capacity of photosynthesis ( A ), leading a depression photosynthetic efficiency and eventually photooxidation (i.e., leaf chlorosis). Yet, it remains unclear which processes play key role in limiting energy utilization Mg‐deficient leaves, whether plasticity acclimation irradiance could have cross‐talk with Mg, hence accelerating or mitigating photodamage. We...