A5085155421- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Extracellular vesicles in disease
- Click Chemistry and Applications
- Immunodeficiency and Autoimmune Disorders
- Supercapacitor Materials and Fabrication
- Virus-based gene therapy research
- Dendrimers and Hyperbranched Polymers
- Esophageal Cancer Research and Treatment
- Advanced battery technologies research
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Nanomaterials for catalytic reactions
- Immune Cell Function and Interaction
- Carbon Dioxide Capture Technologies
- Bacteriophages and microbial interactions
- Inflammatory Biomarkers in Disease Prognosis
University of Illinois Urbana-Champaign
2019-2025
Changzhi Medical College
2022-2025
Affiliated Hospital of Southwest Medical University
2023-2025
Materials Science & Engineering
2025
Tongji University
2014-2024
Shanghai Tenth People's Hospital
2019-2024
Xi'an University of Architecture and Technology
2024
China Medical University
2009-2022
Shanxi Medical University
2012-2022
Zhejiang University of Technology
2021
Abstract The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a robust, durable broad immune protection multiple viral variants. However, antibody responses to current vaccines often lack robust cross-reactivity. Here we describe polymeric Toll-like receptor 7 agonist nanoparticle (TLR7-NP) adjuvant, which enhances lymph node targeting, leads persistent activation of cells responses. When mixed with alum-adsorbed antigens, this TLR7-NP adjuvant elicits...
Homopolymers have been considered as a nonideal building block for creating well-defined nanostructures due to their fuzzy boundary between hydrophobic and hydrophilic moieties. However, this unique may provide some opportunities fabricating functional nanomaterials. Presented in paper is pH-responsive multifunctional homopolymer vesicle based on poly[2-hydroxy-3-(naphthalen-1-ylamino)propyl methacrylate] (PHNA). This confirmed be an excellent supporter gold nanoparticles (AuNPs) facilitate...
Nitrogen-doped hollow carbon spheres were prepared from scalable homopolymer vesicles and used as the electrode materials of high-performance supercapacitors.
Abstract As key mediators of cellular communication, extracellular vesicles (EVs) have been actively explored for diagnostic and therapeutic applications. However, effective methods to functionalize EVs modulate the interaction between recipient cells are still lacking. Here we report a facile universal metabolic tagging technology that can install unique chemical tags (e.g., azido groups) onto EVs. The surface enable conjugation molecules via efficient click chemistry, tracking targeted...
Abstract Dendritic cell (DC) vaccine was among the first FDA-approved cancer immunotherapies, but has been limited by modest cytotoxic T lymphocyte (CTL) response and therapeutic efficacy. Here we report a facile metabolic labeling approach that enables targeted modulation of adoptively transferred DCs for developing enhanced DC vaccines. We show glycan can reduce membrane mobility DCs, which activates improves antigen presentation subsequent priming property DCs. Metabolic itself enhance...
Infections by intracellular pathogens are difficult to treat because of the poor accessibility antibiotics encased host cell membranes. As such, a strategy that can improve membrane permeability would significantly increase their efficiency against pathogens. Here, we report design an adaptive, metaphilic cell-penetrating polypeptide (CPP)–antibiotic conjugate (VPP-G) effectively eradicate bacteria both in vitro and vivo. VPP-G was synthesized attaching vancomycin highly membrane-penetrative...
Inhibition of overexpressed enzymes is among the most promising approaches for targeted cancer treatment. However, many cancer-expressed are “nonlethal,” in that inhibition enzymes’ activity insufficient to kill cells. Conventional antibody-based therapeutics can mediate efficient treatment by targeting extracellular nonlethal targets but hardly target intracellular enzymes. Herein, we report a and strategy utilize through combination selective stem-like cell (CSC) labeling Click...
390 Background: Combining epigenetic modulator with PD-1 inhibitor may enhance treatment outcomes in cancer patients. This study aimed to evaluate the efficacy and safety of drug decitabine, sintilimab (a inhibitor), chemotherapy gastric cancer. Methods: In this single-arm, exploratory phase II trial, patients HER2-negative, locally advanced or metastatic gastroesophageal junction (G/GEJ) adenocarcinoma were enrolled between August 12, 2021, October 22, 2022. Treatment included low-dose...
488 Background: The study evaluated the efficacy and safety of camrelizumab combined with platinum-based chemotherapy (platinum plus paclitaxel [TP] or fluorouracil [FP] agents) as first-line treatment in patients advanced esophageal squamous cell carcinoma (ESCC), explored potential biomarkers for response using immune repertoire (IR) sequencing. Methods: In this multi-center, prospective cohort study, ESCC were treated TP FP chemotherapy. Primary outcome was 1-year progression free...
Extracellular vesicles (EVs) have been actively explored for therapeutic applications in the context of cancer and other diseases. However, poor tissue retention EVs has limited development EV-based therapies. Here we report a facile approach to fabricating injectable EV hydrogels with tunable viscoelasticity gelation temperature, by metabolically tagging azido groups further crosslinking them dibenzocyclooctyne-bearing polyethylene glycol via efficient click chemistry. One such gel...
Effective inhibition of bacteria and removal carcinogenic organic pollutants such as polycyclic aromatic hydrocarbons (PAHs) are important technical challenges in water purification because most the traditional filter membranes prone to being biologically contaminated by difficult off PAHs. Herein we present synthesis characterization a novel multifunctional nanocapsule (vesicle) based on statistical copolymer, poly[[2-hydroxy-3-(naphthalen-1-ylamino)propyl...
Lipid nanoparticle (LNP)-based mRNA delivery has a lot of potential in combating wide range diseases, but delivering to specific cell types continues be challenging. Despite recent advances organ and specificity, the majority clinical LNP systems cannot fully release their payload targeted site. Incorporating active targeting moieties into LNPs is highly desired expand nanomedicine applications. In this Letter, we developed that harness power bioorthogonal "click" azide-alkyne chemical...
The vacuum pressure swing adsorption (VPSA) method, as an alternative way to separate the CH4/N2 mixture, was adopted purify methane from coal mine methane. performance of VPSA process investigated experimentally and theoretically with a reactivated carbon molecule sieve adsorbent. computer calculations were compared experimental data. concentrated 79% purity could be collected directly during high-pressure step 93% recovery 0.0720 mL·g–1·min–1 productivity, when composition raw gas 10/90...