A5078539495- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Colorectal and Anal Carcinomas
- Biomarkers in Disease Mechanisms
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Anesthesia and Pain Management
Changzhi Medical College
2017-2025
Weatherford College
2020-2024
Shanxi Medical University
2022
Tianjin Economic-Technological Development Area
2022
Tianjin Research Institute of Water Transport Engineering
2022
First Hospital of China Medical University
2009-2010
China Medical University
2009-2010
Malnutrition in cancer patients is a common but under-diagnosed condition that has negative effects on clinical outcomes. The development of an easy and reliable malnutrition assessment tool thus critical for identification nutritional support. We aimed to develop phase angle (PA)-based prediction model evaluate it patient prognosis.A retrospective cohort data consisting demographic, parameter PA test from 702 adult hospitalized between June 2020 February 2021 was analysed. PAs 6 body sites...
390 Background: Combining epigenetic modulator with PD-1 inhibitor may enhance treatment outcomes in cancer patients. This study aimed to evaluate the efficacy and safety of drug decitabine, sintilimab (a inhibitor), chemotherapy gastric cancer. Methods: In this single-arm, exploratory phase II trial, patients HER2-negative, locally advanced or metastatic gastroesophageal junction (G/GEJ) adenocarcinoma were enrolled between August 12, 2021, October 22, 2022. Treatment included low-dose...
488 Background: The study evaluated the efficacy and safety of camrelizumab combined with platinum-based chemotherapy (platinum plus paclitaxel [TP] or fluorouracil [FP] agents) as first-line treatment in patients advanced esophageal squamous cell carcinoma (ESCC), explored potential biomarkers for response using immune repertoire (IR) sequencing. Methods: In this multi-center, prospective cohort study, ESCC were treated TP FP chemotherapy. Primary outcome was 1-year progression free...
This study evaluated the efficacy and safety of camrelizumab combined with platinum-based chemotherapy (taxanes [T] or fluorouracil agents [F] plus platinum [P] drugs) as first-line treatment in advanced esophageal squamous cell carcinoma (ESCC), using immune repertoire sequencing (IRS) to explore response mechanism. In this multi-center, prospective cohort study, 88 patients received TP FP, achieving a 1-year progression-free survival 56.8% overall 68.2%. The objective rate (ORR) was 64.8%,...
To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients evaluate role in peritoneal metastasis cancer.Methylation gene 40 paired samples its corresponding adjacent normal mucosa, lymph nodes irrigation fluid was detected by methylation-specific polymerase chain reaction.Aberrant 27.5% (11/40) mucosa samples, 47.5% (19/40) 57.1% (12/21) node 35% (14/40) respectively, with a significant difference (P = 0.023). Presence primary...
Colorectal cancer (CRC) is the most common malignant tumor type and has become resistant to 5‑fluorouracil (5‑FU) in recent decades, which one of popular therapies. Recently, microRNA (miRNA or miR) been investigated as a potential therapeutic strategy for CRC. However, there little investigation underlying mechanism association between expression miRNA chemosensitivity. The present study aimed investigate effect miR‑1260b inhibitor on CRC cells, their chemosensitivity 5‑FU, by treating them...
Abstract Objectives The purpose of this study was to explore the clinical application value phase angle (PA) six parts in nutritional evaluation and construct a prediction model for diagnosing malnutrition tumor patients. Methods A total 1129 patients with malignant tumors were analyzed retrospectively. age, sex, location body mass index (BMI) collected, PA measured. Patient Subjective Global Assessment (PG-SGA) used evaluate status each patient. Results According PG-SGA, 66.5% ( n = 750)...
Penile cancer is a rare malignant disease. Paclitaxel combined with platinum often used as first-line chemotherapeutic regimen for late-stage penile cancer, and there no standard second-line treatment. Clinical trials of immunotherapy are ongoing. There reports on PD1 inhibitor treatment in metastatic carcinoma patients MMR/MSI status heterogeneity. A 68-year-old patient was hospitalized bilateral inguinal lymph node metastasis local recurrence after surgery. The lesion the right showed...
Nutritional risk screening 2002 (NRS2002) is a commonly used tool for the of malnutrition in hospitalized patients, while patient-generated subjective global assessment (PG-SGA) nutritional malignant tumor patients. However, there are still gaps rapid methods cancer We aimed to evaluate value abridged scored (abPG-SGA) and prognosis The NRS abPG-SGA scores 100 patients our department December 2020 were collected. Take NRS2002 ≥ 3 as positive standard (risk malnutrition). Data analyzed using...
Immune-related adverse events (irAEs) impact outcomes, with most research focusing on early prediction (baseline data), rather than near-term (one cycle before the occurrence of irAEs and current cycle). We aimed to explore predictive value neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), absolute eosinophil count (AEC) for severe induced by PD-1 inhibitors. Data were collected from tumor patients treated NLR, PLR, AEC data obtained both previous cycles occurrence. A model was...
The peroxisome serves a significant role in the occurrence and development of cancers. Specifically, peroxisomal biogenesis factor 13 (PEX13) is crucial to peroxisomes. However, biological function PEX13 cancers remains unclear. To address this, various portals databases such as Cancer Genome Atlas Program, Genotype‑Tissue Expression project, Gene Profiling Interactive Analysis 2, cBioPortal, Genomic Identification Significant Targets In 2.0, Tumor Immune Estimation Resource SangerBox,...
e16084 Background: The introduction of immune checkpoint inhibitors (ICIs) after chemotherapy and targeted therapy has altered the treatment pattern esophageal squamous cell carcinoma (ESCC). However, using ICIs alone results in a poor response rate. Fortunately, fundamental research indicates that might trigger immunogenic death tumor cells by releasing antigens, hence eliminating system repression cells. On this basis, number clinical studies, including KEYNOTE-590, CheckmMate-648,...
Aim: This research investigated the therapeutic effect of an allogeneic mouse brain microvascular endothelial cell vaccine on lung cancer and further elucidated its potential anti-angiogenic mechanism.Materials & methods: The immune bEnd.3 DC loaded with antigen subcutaneous transplantation Lewis (LLC) was assessed by ELISA, CCK test CTL killing test. mechanism preliminarily revealed immunohistochemistry immunoblot analysis.Results: study that tumor volume decreased (p < .01) survival...
e24107 Background: The safety and efficacy of PEGylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for prevention chemotherapy-induced neutropenia (CIN) in patients undergoing oral chemotherapy remain unclear. This study investigated the PEG-rhG-CSF as primary prophylaxis against CIN gastrointestinal (GI) cancer receiving combination regimens involving agents. Methods: is a prospective, single-center, open-label, exploratory, non-randomized controlled study. GI two...
A 74-yr-old man underwent thoracic laparoscopy combined with radical gastrectomy, and the postoperative pathological diagnosis was esophageal gastric cardia cancer pT3N1M0, pStage IIB. Immunohistochemical staining for HER2 (3+) PD-L1 (<5%) positive. Adjuvant chemotherapy not performed because patient developed severe thrombocytopenia (platelet counts <30 × 109/L), which never cured throughout reporting period. At 10.7 months post-surgery, he suffered metastases in multiple organs, including...
3147 Background: Immune checkpoint inhibitors have opened a new chapter in cancer therapy, but the incidence of irAEs caused by them is high, and severe can be fatal. The current research on almost focused early predictions, there lack near-term predictions (the cycle before occurrence irAEs). Absolute eosinophil count (EO#) has been reported to associated with immune-related pneumonia, its association other systemic requires further exploration. aim this study was explore predictive value...
To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer evaluate role peritoneal lavage fluid in detecting metastases. The status gene 40 specimens, corresponding adjacent normal mucosa, lymph nodes was investigated by methylation-spcific polymerase chain reaction(MS-PCR). Aberrant detected 55%(22/40) 82.5% (33/40)of 80.95%(17/21) nodes, 42.5%(17/40) fluid. Methylation carcinoma lymphonode more frequent than non-neoplastic gastiric...