A5008301735- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Carbon dioxide utilization in catalysis
- RNA Interference and Gene Delivery
- Organometallic Complex Synthesis and Catalysis
- Supramolecular Self-Assembly in Materials
- Polymer composites and self-healing
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Covalent Organic Framework Applications
- Chemical Synthesis and Reactions
- Dendrimers and Hyperbranched Polymers
- Antimicrobial agents and applications
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Lignin and Wood Chemistry
- Virus-based gene therapy research
- Luminescence and Fluorescent Materials
- Polydiacetylene-based materials and applications
- Bacteriophages and microbial interactions
- Synthesis and properties of polymers
- Nanomaterials for catalytic reactions
- Ocular Infections and Treatments
- Polymer Nanocomposites and Properties
- Aerodynamics and Acoustics in Jet Flows
Tongji University
2013-2025
Shanghai Tenth People's Hospital
2020-2023
Imperial College London
2014-2021
NIHR Imperial Biomedical Research Centre
2021
Ministry of Education
2020
Kensington Health
2019
Transnational Press London
2019
University of Oxford
2016-2019
Xi'an Jiaotong University
2019
Mansfield University
2019
Controlled routes to prepare polyesters and polycarbonates are of interest due the widespread application these materials opportunities provided new copolymers. Furthermore, ring-opening copolymerization may enable poly(ester-carbonate) be prepared which inaccessible using alternative polymerizations. This review highlights recent advances in catalysis, epoxides coupled with anhydrides or CO2, produce polycarbonates. In particular, structures performances various homogeneous catalysts...
Controlling polymer composition starting from mixtures of monomers is an important, but rarely achieved, target. Here a single switchable catalyst for both ring-opening polymerization (ROP) lactones and copolymerization (ROCOP) epoxides, anhydrides, CO2 investigated, using experimental theoretical methods. Different combinations four model monomers—ε-caprolactone, cyclohexene oxide, phthalic anhydride, carbon dioxide—are investigated dizinc catalyst. The switches between the distinct cycles...
Thermosets are important commodity polymeric materials, but they rarely biorenewable and recyclable. Although some previously reported bio-based aromatic thermosets with a high content have good thermal/mechanical properties, the mechanical properties of fully vitrimers relatively poor owing to low contents. To address this issue, vanillin-based dialdehyde trialdehyde containing were synthesized, renewable diamines short aliphatic chains carefully screened. Then, prepared via Schiff base...
Selective catalysis is used to prepare block copolyesters by combining ring-opening polymerization of lactones and copolymerization epoxides/anhydrides. By using a dizinc complex with mixtures up three different monomers controlling the chemistry Zn-O(polymer chain) it possible select for particular route thereby control composition copolyesters.
Antibacterial polypeptides as ancient immune defense systems are effective against bacteria. Here we report a novel kind of "armed" carrier: an antibacterial polypeptide-grafted chitosan-based nanocapsule with excellent efficacy both Gram-positive and Gram-negative This also has blood compatibility low cytotoxicity. Patients after tumor surgery may benefit from this carrier because it is highly anti-inflammation able to deliver anticancer antiepileptic drugs simultaneously.
Di-zinc and di-magnesium catalysts for the ring-opening copolymerization of phthalic anhydride cyclohexene oxide are presented. They applied in terpolymerizations to prepare block copoly(ester-carbonates).
In this study, we investigated the utility of antimicrobial blue light therapy for multidrug-resistant Acinetobacter baumannii infection in a mouse burn model. A bioluminescent clinical isolate A. was obtained. The susceptibility to (415 nm)-inactivation compared vitro that human keratinocytes. Repeated cycles sublethal inactivation bacterial by were performed investigate potential resistance development light. model third degree infected with developed. single exposure initiated 30 minutes...
Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA (mRNA), thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or and do not necessarily deliver saRNA efficiently due structural differences of these RNAs, motivating development platforms. Here, we engineer a bioreducible, linear, cationic polymer called "pABOL" show that increasing its molecular weight enhances both vitro...
Homopolymers have been considered as a nonideal building block for creating well-defined nanostructures due to their fuzzy boundary between hydrophobic and hydrophilic moieties. However, this unique may provide some opportunities fabricating functional nanomaterials. Presented in paper is pH-responsive multifunctional homopolymer vesicle based on poly[2-hydroxy-3-(naphthalen-1-ylamino)propyl methacrylate] (PHNA). This confirmed be an excellent supporter gold nanoparticles (AuNPs) facilitate...
Self-assembly of amphiphilic homopolymers composed both hydrophilic and hydrophobic components in each repeating unit is burgeoning recent years due to their facile synthesis compared block copolymers. However, ordered homopolymer nanostructures are very limited, solid TEM evidence for the formation vesicles other complex morphologies necessary address mechanistic insights self-assembly. Presented this article studies on morphological transition, structure analysis, mechanism First, a series...
Nitrogen-doped hollow carbon spheres were prepared from scalable homopolymer vesicles and used as the electrode materials of high-performance supercapacitors.
Well-defined pentablock copolymers are prepared using a single catalyst, in one pot, from four different monomers: anhydride, epoxide, lactone, and CO2. The dizinc catalyst bridges three distinct polymerization cycles performs double switch mechanism to produce copolymers. new materials hydroxyl-telechelic efficiently postfunctionalized introduce polar nonpolar side-chains.
Self-amplifying RNA (saRNA) is a next-generation vaccine platform, but like all nucleic acids, requires delivery vehicle to promote cellular uptake and protect the saRNA from degradation. To date, platforms for have included lipid nanoparticles (LNP), polyplexes cationic nanoemulsions; of these LNP are most clinically advanced with recent FDA approval COVID-19 based-modified mRNA vaccines. While effect on immunogenicity well studied, role biomaterials in effectiveness under investigated....
Diabetic wounds are difficult to heal due recurrent bacterial infection, decreased proliferation, and migration of epidermal endothelial cells. This is related impaired leukocyte function low blood concentrations H2S in diabetic patients. Herein, an antibacterial polymersome-based wound dressing spray was demonstrated for complete healing. The designed polymersome self-assembled from poly(ε-caprolactone)24-block-poly[lysine15-stat-(S-aroylthiooxime)23] [PCL24-b-P(Lys23-stat-SATO15)], where...
This review highlights the recent advances and synthetic routes for development of different vanillin-based polymers, including thermosets, thermoplastics, covalent adaptable networks (CANs), their properties.
Chemical reactions with incompatible mechanisms (such as nucleophilic and electrophilic reactions, cationic polymerization anionic polymerization) are usually difficult to perform simultaneously in one-pot. In particular, synchronous cationic-anionic has been an important challenge the field of polymer synthesis due possible coupling termination both chain ends. We recently found that such terminal couplings can be significantly inhibited by a bismuth salt strong anion (e.g., BiCl3)...
The facile loading of sensitive and fragile biomacromolecules, such as glucose oxidase, hemoglobin, ribonucleic acid (RNA), via synthetic vehicles directly in pure aqueous media is an important technical challenge. Inspired by the nucleus pore complex that connects cell cytoplasm across nuclear envelope, here we describe development a kind polymeric envelope-like vesicle (NEV) to address this problem. NEV tailored form polymer (70 nm, similar complex) within membrane based on nanophase...
Polyester block polymers containing polylactide have garnered significant attention as renewable, degradable alternatives to traditional elastomers. However, the low glass transition of PLA blocks limits upper-use temperatures resulting To improve thermal performance, we explore a series multiblock polyesters composed poly(ε-decalactone) (PDL) and poly(cyclohexene phthalate) (PCHPE). These materials are prepared using switchable polymerization catalysis followed by chain extension. The...
Polyurethanes are widely used polymeric materials, but they rarely biorenewable and degradable. Although some previously reported bio-based polyurethanes exhibit good thermal mechanical properties, their bio-content is usually low, resulting from the only replacement of diol monomer instead whole diol/diisocyanate pairs. In addition, traditional often difficult to degrade, leading environmental issues. To address these issues, we propose a solution by sourcing both diols isocyanates...
A novel thermo- and pH-responsive antimicrobial diblock copolymer has been synthesized directly dissolved in water to form polymer vesicles upon simply raising the temperature. Compared individual chains, exhibit much better efficacy against both Gram-negative Gram-positive bacteria under physiological conditions with neither quaternary ammonium moieties nor loading of any external antibiotics as a result their increased local concentration cationic charge.
A series of AB alternating polyesters are orthogonally patterned to install two different functionalities at regular intervals along the backbone and with high precision.