A5100742109- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Membrane Separation Technologies
- Optical Imaging and Spectroscopy Techniques
- Nanoplatforms for cancer theranostics
- Antimicrobial Peptides and Activities
- Nanopore and Nanochannel Transport Studies
- Laser Material Processing Techniques
- Graphene research and applications
- Polydiacetylene-based materials and applications
- Congenital heart defects research
- Ocular and Laser Science Research
- Supramolecular Self-Assembly in Materials
- Flavonoids in Medical Research
- Diverse Scientific Research Studies
- Advanced Drug Delivery Systems
- Water Quality Monitoring Technologies
- Protein Interaction Studies and Fluorescence Analysis
- Phytochemical compounds biological activities
- Synthesis of heterocyclic compounds
- Photodynamic Therapy Research Studies
- Speech and Audio Processing
- Access Control and Trust
- Flood Risk Assessment and Management
- Advanced Neural Network Applications
Nantong University
2025
Fuzhou University
2022-2025
Forschungszentrum Jülich
2024
RWTH Aachen University
2024
Xiangya Hospital Central South University
2024
Central South University
2024
Sichuan University
2024
Wuhan University of Technology
2020
Sichuan Provincial Hospital of Traditional Chinese Medicine
2020
Fujian Normal University
2010-2016
Argonaute (Ago) proteins are ubiquitous across all kingdoms of life. Eukaryotic Agos (eAgos) use small RNAs to recognize transcripts for RNA silencing in eukaryotes. In contrast, the functions prokaryotic counterparts (pAgo) less well known. Recently, short pAgos conjunction with associated TIR or Sir2 (SPARTA SPARSA) were found serve as antiviral systems combat phage infections. Herein, we present cryo-EM structures nicotinamide adenine dinucleotide (NAD
We report our pilot results on quantification of glucose (G) diffusion permeability in human normal esophagus and ESCC tissues vitro by using OCT technique. The coefficient 40% aqueous solution G was found to be (1.74±0.04)×10-5 cm/s (2.45±0.06)×10-5 tissues. from this study indicate that had a higher compared esophageal tissues, the light penetration depths gradually increase with applied topically time for cancer 1.41-fold than depth is significantly smaller same range. These demonstrate...
The purpose of study is to quantify and compare diffusion propylene glycol, glucose, glycerol in the human skin vivo noninvasively. Optical coherence tomography (OCT) was utilized functional imaging optical cleaning agents for monitoring quantifying permeability coefficients (PCs) them. Our experiments showed that coefficient 40% glycol from different subjects averaged found be (2.52 ± 0.02) × 10−6 cm/s, glucose (1.94 0.05) (1.82 0.04) cm/s. results indicated solutions faster than solution,...
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by tissue heterogeneity and high postoperative recurrence risk. This study aims to employ cytokine analyses identify serum biomarkers associated CRSwNP elucidate underlying recurrent mechanisms. METHODS: A prospective cohort was conducted on patients undergoing functional endoscopic sinus surgery. Serum samples were collected analyzed for multiple cytokines. Participants followed 3 years categorized into...
Iodinated contrast media (ICM) molecules are widely used in medical diagnostic imaging. With the increasing consumption of ICM, these compounds have been identified groundwater and surface water systems. However, effect environmental pollutants on living organisms remains inadequately studied. Herein, we employed molecular dynamics (MD) simulations to investigate interactions between ICM cell membranes. Our findings indicated that entry behavior into membrane is dependent their chemical...
Diltiazem and glibenclamide are commonly used hypotensive antidiabetic drugs. This study reports the discovery of potential antitumor antimetastatic effects these two drugs using a structural dynamics-driven virtual screening targeting urokinase receptor (uPAR). Owing to uPAR's high flexibility, currently resolved crystal structures uPAR, all in ligand-bound states, provide limited representations its physiological conformation. To improve accuracy screening, we performed long-timescale...
The popularity of the Internet has brought profound influence to electronic commerce. A kind review-oriented consumption mode is gradually expanding in market and consumers will refer reviews provided by who bought product past. How accurately analyze users' sentiments from massive data e-commerce become one key issues for platforms. Current standard sentiment analysis classifies overall without an extended description entity. We set up optimized Aspect-based (ABSA) that includes four...
The main objective of the present work is to study influence heat treatment on esophageal cancer detection using diffuse reflectance (DR) spectral intensity ratio R540/R575 oxygenated hemoglobin (HbO2) absorption bands distinguish epithelial tissues normal human esophagus and moderately differentiated squamous cell carcinoma (ESCC) at different temperature 20, 37, 42, 50, 60°C, respectively. DR spectra for ESCC in vitro heat-treatment wavelength range 400–650 nm were measured with a...
Using optical coherence tomography (OCT) and diffuse reflectance spectra, we investigated the dynamics of titanium dioxide (TiO2) nanoparticles, different sizes, when penetrating accumulating in human normal colon tissue (NC) adenomatous (AC). The process nanoparticle penetration accumulation biotissue is accompanied by changes properties tissue. Continuous OCT monitoring showed that, after application TiO2 signal intensities NC ac both increase with time, larger nanoparticles tend to...
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide has led to over 600 million cases disease 2019 (COVID-19). Identifying effective molecules that can counteract the virus is imperative. SARS-CoV-2 macrodomain 1 (Mac1) represents a promising antiviral drug target. In this study, we predicted potential inhibitors Mac1 from natural products using in silico-based screening. Based on high-resolution crystal structure bound its endogenous ligand ADP-ribose...
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The WAVE regulatory pentameric complex regulates actin remodeling. Two components of it (CYFIP2 and NCKAP1) are encoded by genes whose genetic mutations increase the risk for Autism Spectrum Disorder (ASD) related neurodevelopmental disorders. Here, we use a newly developed computational protocol hotspot analysis to uncover functional impact these at interface correct isoforms two proteins into complex. turn out be located on surfaces involving largest number hotspots Most them decrease...
Previous studies from our group have demonstrated that glucose solution can induce optical clearing enhancement of esophageal tissues with coherence tomography (OCT). The aims this study were to evaluate the effects ultrasound-mediated agents (OCAs) and find more effective methods distinguish human normal (NE) cancerous (CE). Here we used OCT technique investigate attenuation NE CE in vitro after treatment 30% glycerol alone combined ultrasound, respectively. Experimental results showed...
The present study is concerned with the in vitro of different sized titanium dioxide (TiO2) nanoparticles' (NPs) penetration and accumulation human normal lung (NL) tissue adenocarcinoma tumor (LAT) by methods continuous optical coherence tomography (OCT) monitoring diffuse reflectance (DR) spectra measurement, their evaluating effects TiO2 NPs two sizes (60 nm 100 nm) combination ultrasound (US) on properties NL LAT tissue. Spectral measurements indicate that penetrate accumulate into...
The transport behaviors of aqueous solution in two-dimensional (2D) nanomaterial-based separation membranes are correlated with the structure nanoconfined geometry. Compared to pristine membranes, aged more likely exhibit asymmetrical stacking structures. However, little is known about impact such asymmetric structures on behavior solutions membranes. In this work, we constructed non-parallel nanochannels graphitic carbon nitride (g-C3N4) nanosheets. Molecular dynamics (MD) simulations...