A5101759481- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Neurological and metabolic disorders
- Folate and B Vitamins Research
- Medical Imaging Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Biochemical effects in animals
- Frailty in Older Adults
- Nutrition and Health in Aging
- Reconstructive Surgery and Microvascular Techniques
- Nutritional Studies and Diet
- Osteoarthritis Treatment and Mechanisms
- Diabetes and associated disorders
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Global Cancer Incidence and Screening
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 detection and testing
- IL-33, ST2, and ILC Pathways
Sun Yat-sen University
2023-2025
Sun Yat-sen Memorial Hospital
2023-2025
Hubei University of Medicine
2020-2024
Xiang Yang No.1 People's Hospital
2024
People’s University
2024
Jinzhou Medical University
2024
Evidence Based Research (United States)
2021-2023
Changshu No.1 People's Hospital
2023
Southwest Medical University
2023
Jilin Medical University
2023
Growing evidence has shown that gut microbiome composition is associated with breast cancer (BC), but the causality remains unknown. We aimed to investigate link between BC prognosis and at various oestrogen receptor (ER) statuses.We performed a genome-wide association study (GWAS) analyse of patients, dataset for which was collected by Breast Cancer Association Consortium (BCAC). The analysis executed mainly via inverse variance weighting (IVW); Mendelian randomization (MR) results were...
Immune cell heterogenicity is known to determine the therapeutic response cancer progression. Neoadjuvant chemoimmunotherapy (NACI) has shown clinical benefits in some patients with advanced head and neck squamous carcinoma (HNSCC), but underlying mechanism behind this unknown. The efficacy of NACI needs be potentiated by identifying accurate biomarkers predict responses. Here, we attempted identify molecules predicting HNSCC.We performed combined single-cell RNA sequencing (scRNA-seq)...
Abstract To explore the association between lipid markers and osteoarthritis (OA). First, National Health Nutrition Examination Survey (NHANES) database was used to screen participants with markers, OA relevant covariates, logistic regression analyze OA; Then, under theoretical framework of Mendelian randomization (MR), two-sample MR performed using GWAS data causal two, which analyzed by inverse variance weighting (IVW) method. Heterogeneity test, sensitivity analysis pleiotropy were also...
Abstract Purpose To use data from the Global Burden of Disease (GBD) Study 2019 to report global, regional and national rates trends deaths incidence, prevalence, disability-adjusted life years (DALYs) for Nasopharynx cancer (NPC) in adolescents young adults (AYAs). Methods Data GBD were used analyze prevalence DALYs due NPC at regional, levels. Joinpoint regression analysis was calculate average annual percentage changes (AAPC). The association between socioeconomic development analyzed...
BACKGROUND: Low back pain is highly prevalent and the main cause of years lived with disability, but data on burden trends low (LBP) in adolescents young adults (AYAs) are sparse. OBJECTIVE: To assess LBP among AYAs aged 15–39 at global, regional national levels from 1990 to 2019. METHODS: Data Global Burden Disease (GBD) 2019 were used analyze incidence, prevalence Disability-adjusted life year (DALY) due regional, levels. Joinpoint regression analysis calculated average annual percentage...
Background: Surgery and postoperative adjuvant therapy is the standard treatment for locally advanced resectable oral squamous cell carcinoma (OSCC), while neoadjuvant chemoimmunotherapy (NACI) believed to lead better outcomes. This study aims investigate effectiveness of NACI regimens in treating OSCC. Materials methods: Patients diagnosed with OSCC who received non-NACI were reviewed between December 2020 June 2022 our single center. The pathologic response was evaluated efficacy...
Introduction The aim of the study was to examine association between frailty and osteoarthritis. Material methods We conducted a cross-sectional in National Health Nutrition Examination Survey, while logistic regression used explore two. Mendelian randomization (MR) causal relationship Results In study, analysis showed that odds ratio (OR) (95% CI) value 1.07 (1.05, 1.08). MR inverse-variance weighting (IVW) results OR 1.69 (1.01–2.83). Conclusions There is both correlation osteoarthritis,...
Summary Objective To describe the epidemiological and clinical characteristics of Coronavirus Disease 2019 (COVID-19) hospitalized patients to offer suggestions urgent needs COVID-19 prevention, diagnosis treatment. Methods We included 102 confirmed cases in Xiangyang No.1 people’s hospital, Hubei, China until Feb 9th, 2020. Demographic data, laboratory findings chest computed tomographic (CT) images were obtained analyzed. Findings All by real-time RT-PCR, including 52 males 50 females with...
Background The study aimed to examine the association between systemic immune-inflammation index (SII), a contemporary metric of inflammatory response, and biological aging, which are closely interconnected processes. Methods This cross-sectional utilized 10 cycles data from NHANES database spanning 1990 2018. examined relationship SII index, calculated as P * N/L, where represents preoperative peripheral platelet count, N neutrophil L lymphocyte aging. Biological aging was assessed through...
Abstract Background To analyse the causal associations of different physical measures with osteoarthritis knee (KOA). Methods Exposure factors (weight, body mass index (BMI), fat percentage, waist circumference, hip waist–hip ratio (WHR), and basal metabolic rate (BMR)), outcome factor KOA were analyzed by inverse-variance weighted (IVW) method, along heterogeneity test, sensitivity pleiotropy analyses. Meta-analysis was used to combine effect values IVW methods in data sources. Results...
Abstract Background The pandemic of coronavirus disease 2019 (COVID-19) has become the first concern in international affairs as novel (SARS-CoV-2) is spreading all over world at a terrific speed. accuracy early diagnosis critical control spread virus. Although real-time RT-PCR detection virus nucleic acid current golden diagnostic standard, it high false negative rate when only apply single test. Objective Summarize baseline characteristics and laboratory examination results hospitalized...
Introduction This study aims to investigate the clinical efficacy of V-Y advanced flap pedicled with freestyle perforator for repairing small range defects in anterior knee region. Methods 8 patients skin and soft tissue defect/necrosis area admitted Changshu No.1 People's Hospital from January 2021 2022 were selected, a defect 4 cm × 3 cm–9 6 cm, designed repair wound area. Adjust size position according number perforating branches found during surgery, cutting 5 cm–14 10 supply was...
Malignant lymphoma (ML) is a group of malignant tumors originating from the lymphatic hematopoietic system. Previous studies have found correlation between circulating immune cells and ML. Nonetheless, precise influence on ML remains uncertain.
Introduction: N6-methyladenosine (m6A) modifications of RNAs are associated with many cancer types. Nevertheless, the function m6A reader IGF2BP2 in oral squamous cell carcinoma (OSCC) has yet to be ascertained. Aims: The objective this investigation was elucidate role OSCC and delineate mechanisms. Method: Elevated expression observed OSCC, overexpression significantly correlated adverse prognostic outcomes patients OSCC. In vitro analyses demonstrated that silencing attenuated...
Background: As the spreading of COVID-19 around global, we investigated characteristics and changes symptoms in patients.Methods: This was an ambispective observational cohort study, 133 confirmed patients were included all over course analyzed qualitatively.The symptoms, their different clinical types, etc. illustrated.Differences periods severities through Chi square test, association with severity LASSO binomial logistic regression analysis.Inter-correlation classification completed.Major...
Abstract Background Coronavirus disease‐2019 (COVID‐19) has spread all over the world and brought extremely huge losses. At present, there is a lack of study to systematically analyze features hydroxybutyrate dehydrogenase (α‐HBDH) in COVID‐19 patients. Methods Electronic medical records including demographics, clinical manifestation, α‐HBDH results outcomes included patients were extracted. Results group was higher than that excluded ( p < 0.001), no significant difference before after...
Objective To explore the clinical effect of artificial dermis combined with split-thickness skin autograft in treating hand thermal compression wounds. Methods Forty-two patients our hospital from January 2016 to October 2022 wounds were divided into two groups. The survival rate autologous grafts seven days after grafting, number operations, total stay, hospitalization cost, and bacterial culture results secretions recorded. visual analog scale was used evaluate wound pain. condition graft...
Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional temporal relationship are currently unclear. Our study aimed to explore association ALT (ALT > 40 U/L) hypertension.Measurements of blood pressure were obtained twice from 2013 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional cross-lagged panel analyses performed dissect hypertension.Longitudinally, we found that baseline was strongly...
Abstract Background To characterize C-reactive protein (CRP) changes features from patients with coronavirus disease 2019 (COVID-19) and to quantify the correlation between CRP value clinical classification. Methods This was a bidirectional observational cohort study. All laboratory confirmed COVID-19 hospitalized in Xiangyang No.1 People’s Hospital were included. Patients’ general information, type, outcome collected. Patients grouped according age, type outcome, their compared. The value,...