A5101730763- Fullerene Chemistry and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Traditional Chinese Medicine Analysis
- Quantum Chromodynamics and Particle Interactions
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Physics of Superconductivity and Magnetism
- Graphene research and applications
- Traditional Chinese Medicine Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Cell death mechanisms and regulation
- Quantum and electron transport phenomena
- RNA modifications and cancer
- Theoretical and Computational Physics
- Carbon Nanotubes in Composites
- Spectroscopy and Chemometric Analyses
- Genomics and Chromatin Dynamics
- Ginseng Biological Effects and Applications
- Insect Resistance and Genetics
- MicroRNA in disease regulation
- Chemical Synthesis and Characterization
- Phagocytosis and Immune Regulation
- Advanced Physical and Chemical Molecular Interactions
- Polyoxometalates: Synthesis and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Jiangsu Province Hospital
2024-2025
Academia Sinica
2025
Academy of Medical Sciences
2025
Nanjing Medical University
2024-2025
Zhejiang University
1996-2024
Tianjin Medical University General Hospital
2018-2024
Sun Yat-sen Memorial Hospital
2015-2022
Sun Yat-sen University
2015-2022
Hangzhou Xixi hospital
2020
The human genome encodes many long non-coding RNAs (lncRNAs). However, their biological functions, molecular mechanisms, and the prognostic value associated with pancreatic ductal adenocarcinoma (PDAC) remain to be elucidated. Here, we identify a fundamental role for lncRNA HOXA transcript at distal tip (HOTTIP) in progression chemoresistance of PDAC.High-throughput microarrays were performed detect expression profiles lncRNAs messenger eight PDAC tissues four tissues. Quantitative real-time...
Our previous study demonstrated that long non-coding RNA (lncRNA) HOTTIP was maximally expressed in PDAC, and promoted cancer cell progression epithelial to mesenchymal transition (EMT). Numerous studies indicated lncRNAs or EMT supported stem cells. However, the role of pancreatic cells (PCSCs) remains unclear. Here, we evaluated mechanism PCSCs. First, analyzed relationship between expression overall disease-free survival 90 patients with PDAC after radical resection. Patients higher had...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Long non‐coding RNAs (lncRNAs) are important regulators in pathological processes, yet their potential roles PDAC poorly understood. Here, we identify fundamental role for novel lincRNA, linc00511, the progression of PDAC. Linc00511 levels tissue specimens and cell lines were examined by quantitative real‐time PCR. Corresponding adjacent non‐neoplastic tissues used as controls. The function linc00511 was determined RNA...
Our recent articles have reported that increased miR-21-5p in brain after traumatic injury (TBI) could improve the neurological outcome through alleviating blood-brain barrier (BBB) damage. miR-21-3p is another mature miRNA derived from pre-miR-21 Dicer Procession other than miR-21-5p. Its roles various diseases, such as tumors and myocardial disease, aroused great interest for research years. To further explore function underlying mechanism of miR-21, especially miR-21-3p, regulating...
Abstract Long non-coding RNAs (lncRNAs) play a pivotal role in pathological processes. However, little information has been published regarding the underlying functions and mechanisms of lncRNAs pancreatic ductal adenocarcinoma (PDAC). A novel lncRNA FEZF1-AS1 its sense-cognate gene ZNF312B were found to be highly expressed human PDAC tissues cell lines, which is associated with disease progression predicts clinical outcome patients. Of note, bioinformatics analysis, luciferase assays RNA...
Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is widely present in cereals and agricultural products.
Background and Aims: Reliable novel noninvasive biomarkers for the diagnosis of advanced liver fibrosis are urgently needed in clinical practice. We aimed to investigate accuracy plasma Follistatin-like protein 1 (FSTL-1) chronic diseases. Approach Results: collected cross-sectional data a derivation cohort (n = 86) validation 431), totaling 517 subjects with biopsy. Advanced was defined by METAVIR pathological score (F ≥3). Dual cutoff values were explored. In cohort, FSTL-1 levels...
The long noncoding RNA, homeobox transcript antisense RNA (Hotair), has been demonstrated to have an important role in regulating various biological processes cancers, including hepatocellular carcinoma (HCC). However, the importance of Hotair HCC proliferation and cell cycle progression remains be elucidated. In present study, knockdown HOTAIR expression by interference inhibited induced G0/G1 arrest Huh7 cells. addition, levels CCND1 mRNA its cyclin D1 protein product were reduced cells...
Primary liver cancer (PLC) is a primary cause of cancer-related death worldwide, and novel treatments are needed due to the limited options available for treatment tumor heterogeneity. 66 surgically removed PLC samples were cultured using self-developed 2:2 method, final success rate organoid culture was 40.9%. Organoid performance has been evaluated comprehensive molecular measurements, such as whole-exome RNA sequencing, well anticancer drug testing. Multiple organoids their corresponding...
Four new cadmium carboxyphosphonates with 2D layered and 3D supramolecular structure have been hydrothermally synthesized. Their luminescence molecular recognition properties studied.
ABSTRACT The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. integration immune checkpoint inhibitors (ICIs) with molecularly targeted therapies emerging as strategy to enhance responses. However, efficacy and underlying mechanisms these treatments in BTC are still largely unexplored. In this study, tissue samples from 19 patients treated camrelizumab apatinib were analysed using NanoString 289‐panel identify key molecular...
Liver transplantation (LT) remains the primary treatment for irreversible liver failure. However, challenges in organ preservation, particularly ischemia-reperfusion injury and donor vulnerability, contribute to poor post-transplant outcomes.[1,2] The accumulation of reactive oxygen species (ROS) exacerbates these issues, leading inflammation, tissue damage, impaired graft function.[3] Ceria nanoparticles have gained attention their antioxidant, antibacterial, antifibrotic properties...
Hypoxia-inducible factor-2α (HIF-2α) plays an important role in increasing cancer progression and distant metastasis a variety of tumour types. We aimed to investigate its biological function clinical significance human pancreatic ductal adenocarcinoma (PDAC). A total 283 paired PDAC tissues adjacent normal were collected from patients who underwent surgery or biopsy at Sun Yat-sen Memorial Hospital between February 2004 October 2016. In this study, we noted that HIF-2α expression was...
This study aimed to establish a rapid and comprehensive method for quantitative determination of complex ingredients in Traditional Chinese Medicine injections.A 1H nuclear magnetic resonance was developed simultaneously quantify chemical components Danshen Injection. Multivariate statistical analysis technique applied quality evaluation multiple batches injection.A complete signal attribution the spectrum injection performed first time. A total 32 were identified from Among them, 20...
The Cerambycidae (longhorn beetle) is a large family of Coleoptera with xylophagous feeding habits. Cellulose digestion plays an important role in these wood-feeding insects. In this study, transcriptomic technology was used to obtain one glycoside hydrolase 45 (GH45) cellulase and seven GH5 cellulases from Mesosa myops, typical longhorn beetle. Analyses expression dynamics evolutionary relationships provided complete description the cellulolytic system. related individual development...
Herbal medicines have played a vital role in maintaining the health of world population past thousands years, and proved to be an effective therapy. It is important improve our understanding effects multi-step processing herbal on chemical changes ensure product quality. A proton nuclear paramagnetic resonance (1H NMR)-based evaluation strategy was developed for efficient process variation exploration diversified metabolite identification. In this study, 48 intermediates from 6 commercial...
Trichosanthis Pericarpium injection (TPI) is a traditional Chinese medicine preparation obtained from by extraction, purification and sterilisation. It contains amino acids, alkaloids, nucleotides other components. Existing quantitative methods only analyse few components in injections, so this study intends to develop method for comprehensive analysis of TPI components.To quantification multivariate curve resolution-alternating least squares (MCR-ALS) assisted proton nuclear magnetic...