A5088725853- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Neuroblastoma Research and Treatments
- Mesenchymal stem cell research
- Bone health and treatments
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Anesthesia and Pain Management
- RNA Research and Splicing
- Pediatric Pain Management Techniques
- Tracheal and airway disorders
Tianjin Medical University General Hospital
2016-2025
Tianjin Medical University Cancer Institute and Hospital
2024-2025
Jiangxi Normal University
2025
Cancer Institute (WIA)
2023-2024
Shanghai Ocean University
2021-2024
Hubei University of Medicine
2024
Shanghai Children's Medical Center
2024
Zhejiang Provincial People's Hospital
2024
Hangzhou Medical College
2024
Ganzhou People's Hospital
2021
BackgroundIncreased blood pressure is the biggest contributor to global burden of disease and mortality. Data suggest that less than half population with hypertension aware it. May Measurement Month was initiated raise awareness importance as a pragmatic interim solution shortfall in screening programmes.MethodsThis cross-sectional survey included volunteer adults (≥18 years) who ideally had not their pressures measured past year. Each participant three times received questionnaire about...
Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells that are predominantly localized in the bone marrow (BM). Mesenchymal stromal (MSCs) give rise to most BM interact with MM cells. However, direct involvement MSCs pathophysiology has not been well addressed. In this study, vitro and vivo migration assays revealed have tropism toward cells, CCL25 was identified as major cell-produced chemoattractant for MSCs. By coculture experiments, we found favor proliferation...
Previous studies have demonstrated that mesenchymal stem cells from multiple myeloma (MM) patients (MM-hMSCs) display a distinctive gene expression profile, an enhanced production of cytokines and impaired osteogenic differentiation ability compared to normal donors (ND-hMSCs). However, the underlying molecular mechanisms are unclear. In present study, we observed MM-hMSCs exhibited abnormal upregulation miR-135b, showing meanwhile decrease SMAD5 expression, which is target miR-135b involved...
Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, stomach cancers. Accumulating evidence suggests inherited genetic lung cancer. The present study aimed survey prevalence of pathogenic germline BRCA mutations (gBRCAm) explore potential association between gBRCAm disease onset Chinese advanced non-small cell (NSCLC) patients.A total 6,220 NSCLC patients were...
Abstract Immune checkpoint inhibitor (ICI) rechallenge in non‐small cell lung cancer (NSCLC) is a promising therapeutic strategy. The situation for ICI can be divided into three categories: adverse events (AEs); resistance to ICIs, and becomes compulsive because of tumor relapse while the patients had completed 2 year course immunotherapy. However, these categories are still controversial should explored further. Through voting at 6th Straits Summit Forum on Lung Cancer, this study we...
The study investigates the effectiveness of immersive virtual reality (VR) as a nonpharmaceutical approach to manage postoperative pain in patients following thoracoscopic surgery. In this single-center, triple-arm pilot randomized controlled trial (RCT), 61 postsurgical with numerical rating scale (NRS) score ≥4 after receiving standard analgesia were included and assigned either quantum clinics-VR (QTC-VR) group, Placebo-VR or control group. QTC-VR group engaged daily 10-minute interactive...
Anaplastic lymphoma kinase (ALK) inhibitors have shown efficacy in treating ALK-positive advanced non-small cell lung cancer (NSCLC) patients. However, the effectiveness of ensartinib neoadjuvant therapy remains ambiguous. Herein, we reported that preoperative systemic treatment with ALK inhibitor can be beneficial for initially inoperable tumors. In this study, present a case 60-year-old female patient who was diagnosed stage IIIA (cT2aN2aM0, ninth TNM stage) lower left adenocarcinoma...
Platinum-based chemotherapy, despite being a cornerstone of cancer treatment, faces significant challenges due to acquired drug resistance. To address this issue, we have designed three organelle-targeting platinum(IV) prodrugs conjugated with BODIPY fluorophores, enabling spatiotemporal control through green light irradiation. These BODIPY-Pt(IV) conjugates exhibit excellent stability in PBS buffer, demonstrating resilience under physiological conditions. Upon exposure, these undergo rapid...
Compared to bone marrow (BM) derived mesenchymal stem cells (MSCs) from human origin or other species, the in vitro expansion and purification of murine MSCs (mMSCs) is much more difficult because low MSC yield unwanted growth non-MSCs cultures. We describe a modified protocol isolate expand BM based on combination mechanical crushing collagenase digestion at moment harvest, followed by an immunodepletion step using microbeads coated with CD11b, CD45 CD34 antibodies. The number isolated...
Abstract Recently, we showed that hypoxia is a critical microenvironmental factor in multiple myeloma, and the hypoxia-activated prodrug TH-302 selectively targets hypoxic myeloma cells improves disease parameters vivo. To explore approaches for sensitizing to TH-302, evaluated this study antitumor effect of combination with clinically used proteasome inhibitor bortezomib. First, show bortezomib synergistically induce apoptosis cell lines vitro. Second, confirm synergism related activation...
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is a major challenge targeted therapy for non-small cell lung cancer (NSCLC). We investigated whether cyclin D 4/6 (CDK4/6) inhibitor, PD 0332991, could reverse EGFR-TKI in human cells and explored the underlying mechanisms. found that 0332991 potentiated gefitinib-induced inhibition both EGFR-TKI-sensitive (PC-9) EGFR-TKI-resistant (PC-9/AB2) by down-regulating proliferation inducing apoptosis...
Integrins are involved in extracellular and intracellular signaling often aberrantly expressed tumors. Integrin beta 2 (ITGB2) has previously been demonstrated to be correlated with the host defense. However, expression profile role of ITGB2 non-small-cell lung cancer (NSCLC) remain unclear. Here, we found that genetic alterations was predominated by gene mutation copy number deletion using cBioPortal analysis, its downregulated NSCLC tissues, as validated UALCAN, TCGA, GEO databases our...
In December 2019, China diagnosed the first patient with 2019 novel coronavirus disease (COVID-19), and following development of epidemic had a huge impact on whole world. For patients lung occupying lesions, process diagnosis treatment can not be carried out as usual due to epidemic. thoracic surgeons, timing surgical intervention should very carefully considered. All surgeons in work together develop proper procedures for this special situation, continuously update recommendations based...