A5100642233- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Polyomavirus and related diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 and healthcare impacts
- Congenital Diaphragmatic Hernia Studies
- Peptidase Inhibition and Analysis
- Viral-associated cancers and disorders
- Ultrasound in Clinical Applications
- Appendicitis Diagnosis and Management
- Tracheal and airway disorders
- Bone Tumor Diagnosis and Treatments
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Pleural and Pulmonary Diseases
- Congenital gastrointestinal and neural anomalies
- Metastasis and carcinoma case studies
- Minimally Invasive Surgical Techniques
Tianjin Medical University General Hospital
2013-2024
Tianjin Children's Hospital
2024
Dalian Medical University
2020-2023
Anshan Hospital
2023
Tianjin Medical University
2020
Creative Commons
2015
Chinese University of Hong Kong
2006
Tianjin University of Traditional Chinese Medicine
2003
Pulmonary surgery can significantly impact patients' respiratory function and reduce their quality of life. Previous studies have shown that perioperative breathing exercises (BE) facilitate the recovery lung improve life after surgery. However, due to lack supervision awareness, patients often struggle adhere prescribed exercise regimen. This study statistics analyzes effect postoperative training on undergoing pneumonectomy in a realistic environment, order provide basis for optimizing...
Although metastasis remains the overwhelming cause of death for patients with non-small cell lung cancer (NSCLC), underlying mechanisms remain unknown. Accumulating evidence suggests that microRNAs (miRNAs) are key players in regulation tumor invasion and metastasis. Expression miR-9, miR-10b, miR-145, miR-155, 4 miRNAs previously shown to play roles other types, was compared lymph node (LN)-positive NSCLC versus LN-negative NSCLC. miR-145 significantly lower LN-positive (P < 0.05), while...
In December 2019, China diagnosed the first patient with 2019 novel coronavirus disease (COVID-19), and following development of epidemic had a huge impact on whole world. For patients lung occupying lesions, process diagnosis treatment can not be carried out as usual due to epidemic. thoracic surgeons, timing surgical intervention should very carefully considered. All surgeons in work together develop proper procedures for this special situation, continuously update recommendations based...
Postoperative pneumonia (POP) is a hospital acquired that occurs >48 hours after tracheal intubation. The diagnosis of POP should be based on clinical and radiological findings within 30 days surgery. It common complication thoracoscopic surgery for lung cancer patients. However, the specific impact preoperative comorbidities incidence remains unclear. This study aimed to analyze data patients with help surgeons predict risk resection.
Novel coronavirus pneumonia (NCP), which has swept across China and emerged in several countries around the world since December 2019, attracted global attention. NCP had a huge impact on world's medical, political economic sectors. Since March, under efforts of Chinese government, people guidance "New Coronavirus Pneumonia Diagnosis And Treatment Program (Trial Version 7)" issued by The National Health Commission, PRC...
Immune checkpoint blockades are the most promising therapy in lung adenocarcinoma (LUAD). However, response rate remains limited, underscoring urgent need for effective sensitizers. Interleukin 4 induced 1 (IL4I1) is reported to have immunoinhibitory and tumor-promoting effects several cancers. targetable value of IL4I1 sensitizing immunotherapy not clear, there a lack small molecules that specifically target IL4I1. Here, we show silencing significantly remodels immune microenvironment via...
Primitive neuroectodermal tumors (PNETs) arising directly from the lung are extremely rare but particularly aggressive neoplasms. Although thoracic PNET usually develops on chest wall, there have been reports of primary Ewing sarcoma/PNET lung. We present case a 16-year-old male with diagnosed following histologic and immunohistochemical examination video-assisted surgical biopsy. As typically occurring for these tumors, diagnosis was initially delayed in our patient prognosis poor despite...
Several observational or retrospective studies have previously been conducted to explore the possible association between lung cancer and human papillomavirus (HPV) infection. However, there may be inconsistencies in data conclusions due differences study design HPV testing methods. There are currently no that provide conclusive evidence support involvement of occurrence development cancer. Therefore, relationship remains controversial uncertain. This aimed whether infection is causally...
We present the case of a 66-year-old male patient who was found to have lung nodule during perioperative period for poorly differentiated carcinoma ileocecal region. Subsequent surgical procedures were performed remove intestinal and masses. Next-generation sequencing (NGS) testing demonstrated that lesions exhibited same ALK pathogenic fusion. Following 7 months Alectinib treatment, patient's clinical evaluation showed stable disease. This is first report metastases from cancer with Our...
Superior vena cava syndrome (SVCS) is a common condition predominantly caused by lung cancer. The presence of symptoms SVCS, such as elevated intracranial pressure and laryngeal edema, indicates an unfavorable prognosis for cancer patients. (SVC) stenting the first-line treatment SVCS. In this study, we retrospectively analyzed SVCS cases treated with in our center to explore safety effectiveness SVCS.We reviewed 16 patients who were at endovascular between 2016 2018. Patient information...
Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKI) acquired resistance was an inevitably events in NSCLC treatment. Aims Intending to overcome the of EGFR‐TKI. Materials & Methods A clinical trial was, we enrolled 12 patients who were slowly progressing on first‐generation EGFR‐TKI, and added apatinib when got slow progression. Results Seven included efficacy analysis. The median PFS2 combined with EGFR‐TKI 8.2 months (95% CI, 7.3 m‐NA), total PFS...
The prognostic factors for early-stage nonsmall cell lung cancers (NSCLCs) are not well defined. This study aimed to investigate the effect of highly frequent mutations on outcomes patients with NSCLC, particularly those surgically resected stage I disease.The Cancer Genome Atlas (TCGA) datasets Lung Adenocarcinoma (LUAD), Squamous Cell Carcinoma (LUSC), and Pan-Lung (PLC) were accessed via cBioportal searched identify NSCLC. We identified candidate genes a high (>10%) frequency copy-number...
<b><i>Background:</i></b> Obliterative bronchiolitis (OB) ranks as the major obstacle for long-term survival of lung transplantation patients. Rapamycin (Rapa) has recently been confirmed an immunosuppressant antirejection due to its suppressive role in T cell activation. Here, we explore effect Rapa combined with immature dendritic cells (imDCs) on OB trachea allograft rats. <b><i>Methods:</i></b> The bone marrow-derived imDCs or Rapa-imDCs...
Exploring the role of OPN N-glycosylation in osteoblasts and osteoclasts.Immunohistochemistry was used to detect expression mice with apical periodontitis. The asparagine at position 79 protein mutated glutamine, above plasmids were transfected into osteoclasts. effect on proliferation osteoclasts detected by CCK8 assays. Western blotting osteoblasts. Detection activated NF-κB signaling pathway regulate osteoclasts.OPN increased a model curve resembled reverse V shape. site identified as MS....
In this study, we investigated the role of artemin, a member glial cell-derived neurotrophic factor ligands, in malignant phenotype lung cancer.Artemin expression was examined various types cancer and normal tissues, as well cell lines by immunohistochemistry semi-quantitative PCR. Functional studies were performed using artemin overexpression or knockdown vectors lines. Methyl thiazolyl tetrazolium, flow cytometry, wound healing, transwell assays conducted to evaluate contribution on tumor...
Abstract Hydatidiform moles are gestational trophoblastic disease. They abnormal proliferations of trophoblast cells that have the potential to become cancerous. miR‐miR30a‐5p is a tumour suppressor participates in development numerous diseases. However, role miR‐30a hydatidiform and mechanisms underlying its effects presently unclear. This study explored levels B3GNT5 expression human mole tissue. The results showed were differentially expressed normal placenta mole, decreased cell...
Sarcoidosis is a rare condition that often misdiagnosed as malignant tumors due to the similar clinical manifestations and imaging findings. We encountered 56-year-old Chinese woman who had chief complaint of persistent cough. The chest computer tomography (CT) revealed mediastinal bilateral hilar lymph node enlargement, positron emission tomography-computer (PET-CT) abnormal fluorodeoxyglucose (FDG) uptake in nodes abdomen. To further clarify diagnosis, sampling was performed by...
Background: Invasive pulmonary aspergillosis (IPA) is an opportunistic fungal infection affecting patients who are undergoing chemotherapy for hematological malignancies, have hematopoietic stem cell transplants, and immunosuppressed. Surgical treatment IPA remains challenging controversial due to the potentially high risk of mortality morbidity. Methods: We discuss 4 leukemia underwent surgery in our hospital were successfully treated with curative lobectomy or wedge resection. All had...
Background The purpose of this study was to validate stage groupings in the 8th edition tumor node metastasis (TNM) classification for lung adenocarcinoma and explore non‐anatomic factors that influence prognosis patients China. Methods We retrospectively analyzed data 291 at our department between 2008 2013. Logrank tests Cox regression models were used analyze survival among adjacent groupings. Kaplan–Meier curves estimate overall (OS). Results There significant differences OS early stages...
Venous thromboembolism (VTE) is a recognized complication in lung cancer patients with higher morbidity and mortality. The purpose of this study to determine the incidence lower extremity venous thrombosis (LEDVT) reveal risk factors for LEDVT during admission our center.We first connected 231 admitted Department Lung Cancer Surgery, Tianjin Medical University General Hospital from July 2017 December 2017. All these underwent color ultrasound examination vein on analyze LEDVT. At same time,...