A5100327991- Gut microbiota and health
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Yersinia bacterium, plague, ectoparasites research
- Clostridium difficile and Clostridium perfringens research
- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Pancreatic function and diabetes
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Steroid Chemistry and Biochemistry
- Orthopedic Surgery and Rehabilitation
- Cancer, Lipids, and Metabolism
- Diabetes Management and Research
- Bacillus and Francisella bacterial research
- Transplantation: Methods and Outcomes
- Pancreatitis Pathology and Treatment
- Microbial Metabolites in Food Biotechnology
- Zoonotic diseases and public health
- Thyroid Disorders and Treatments
- Glycosylation and Glycoproteins Research
Ningbo No.6 Hospital
2018-2025
Chinese PLA General Hospital
2024
ZheJiang Academy of Agricultural Sciences
2012-2024
Jiangsu Province Hospital
2012-2024
Nanjing University
2001-2024
Songjiang District Central Hospital
2024
Pharmaceutical Biotechnology (Czechia)
2024
State Key Laboratory of Pharmaceutical Biotechnology
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
The intestinal microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD), and geographical genetic backgrounds impact composition microbiota. However, there is a lack evidence regarding overall changes characteristics fecal-associated (FAM) mucosa-associated (MAM) Chinese patients with IBD. We recruited 26 Crohn's (CD), 46 ulcerative colitis (UC), 21 healthy individuals; we collected matched fresh fecal mucosal samples from same subjects. microbial...
Summary The RNA‐binding protein CsrA represses biofilm formation, while the non‐coding RNAs CsrB and CsrC activate this process by sequestering CsrA. We now provide evidence that pgaABCD transcript, required for synthesis of polysaccharide adhesin PGA (poly‐β‐1,6‐ N ‐acetyl‐ d ‐glucosamine) Escherichia coli , is key target regulation csrA disruption causes an approximately threefold increase in production sevenfold expression a pgaA′–′lacZ translational fusion. A Δ csrB csrC mutant exhibits...
Abstract Background Lactobacillus plantarum is a plant-associated bacterial species but it has also been found in human, mouse and porcine gastrointestinal tracts. It can ferment broad spectrum of plant carbohydrates; tolerant bile salts low pH, antagonistic potential against intestinal pathogens. However, experiments reporting the use L. as probiotic are limited. In this study, effects ZJ316 isolated from infant fecal samples on pig growth pork quality were investigated. Results One hundred...
Abstract Background The aim was to evaluate the changes of 16S rDNA sequencing and LC-MS metabolomics in breast cancer explore growth inhibition cells by Faecalibacterium prausnitzii . Results Total 49 significantly different flora 26 metabolites were screened between two groups, correlation calculated. Relative abudance Firmicutes Bacteroidetes decreased, while relative abundance verrucomicrobla , proteobacteria actinobacteria increased group. Differentially expressed mainly enriched...
Lifestyle choices, external environment, aging, and other factors influence the synthesis of melatonin. Although physiological functions melatonin have been widely studied in relation to specific organs, systemic effects endogenous reduction has not reported. This study evaluates changes possible pathogenic risks an (EMR) mouse model deficient rate limiting enzyme production, arylalkylamine N-acetyltransferase (Aanat) gene. Using this model, we identified a new relationship between...
ABSTRACT Helicobacter pylori infection in humans is associated with chronic type B gastritis, peptic ulcer disease, and gastric carcinoma. A high intake of carotenoids vitamin C has been proposed to prevent development malignancies. The aim this study was explore if the microalga Haematococcus pluvialis rich carotenoid astaxanthin can inhibit experimental H. a BALB/cA mouse model. Six-week-old mice were infected mouse-passaged strain 119/95. At 2 weeks postinoculation treated orally once...
Yak (Bos grunniens) mainly inhabiting Tibet Plateau, displayed a high incidence of diarrhea due to harsh living environment and nutritional deficit. Gut microbial community has been reported be closely related many diseases including diabetes, obesity inflammatory bowel disease, but information regarding diarrheic influence on gut microbiota in yaks remains scarce. Here, this study was performed investigate the bacterial fungal alternations yaks.Results revealed that communities showed...
The development of selective estrogen receptor degraders (SERDs) has brought new ideas for the clinical treatment ER-positive advanced breast cancer. successful application combinational therapy inspired exploration other targets to prevent cancer progression. Thioredoxin reductase (TrxR) is an important enzyme that can regulate redox balance in cells and it was considered as a potential target anticancer treatment. In this study, we firstly combine SERD candidate——G1T48 (NCT03455270), with...
Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointestinal (GI) symptoms in children autism spectrum disorder (ASD). Growing evidence has shown the alterations gut microbiota microbiota-derived metabolites ASD. However, how altered might affect associations between diets GI ASD remains unknown. We analyzed microbiome metabolomics data 90 typically developing (TD) based on 16S rRNA untargeted metabolomics,...
Mitochondrial dysfunction is a hallmark of beta-amyloid (Aβ)-induced neurotoxicity in Alzheimer's disease (AD), and considered an early event AD pathology. Diammonium glycyrrhizinate (DG), the salt form Glycyrrhizin, known for its anti-inflammatory effects, resistance to biologic oxidation membranous protection. In present study, neuroprotective effects DG on Aβ1–42-induced toxicity potential mechanisms primary cortical neurons were investigated. Exposure 2 µM Aβ1–42 resulted significant...
Quercetin, the most widely distributed flavonoid, has been shown to have multiple properties and beneficial effects on various metabolic diseases. Thus, our aim was investigate underlying mechanism whereby quercetin regulates renal lipid accumulation ameliorates early diabetic injuries in Lepr
To verify the role of myricetin in alleviating symptoms type 2 diabetes and regulating intestinal flora, we established a mouse model. After being fed high-fat high-sugar diet for six weeks, mice were intraperitoneally injected with streptozotocin (80 mg/kg body weight [BW]) 2-3 times. Type randomly divided into control (T2DM) intervention groups. Water food intake, fasting blood glucose (FBG), BW monitored weekly. weeks administration, superoxide dismutase (SOD) levels lipid content...
Obesity is a health issue worldwide. This study aimed to evaluate the beneficial effects of Pediococcus pentococcus PR-1 on modulating gut microbiota, inflammation and lipid metabolism in high-fat-diet (HFD)-fed zebrafish.Adult zebrafish were fed commercial (C), high fat (H, 25% fat), probiotic (P, 106 CFU/g), or with (HP) diets twice daily for 5 weeks. Gut microbiota analysed using 16S rRNA gene sequencing. Gene expressions intestinal cytokine, TJ protein, liver by quantitative real-time...
The most common postoperative complication of the Sauvé‒Kapandji (S-K) procedure is proximal ulnar stump instability. distal oblique bundle (DOB) a stable tissue used to stabilize radioulnar joint. This study created finite-element models determine its effect on instability encountered during procedure. We hypothesized that with reconstruction would provide greater stability than without reconstruction. Detailed CT imaging data acquired from pathological specimen wrist joint were imported...
A case of primary pneumonic plague (PPP) caused by Yersinia pestis is reported. This occurred in the largest area China. The patient died after contact with a dog that had captured an infected marmot. Three 151 contacts were shown to be positive for antibody against F1 antigen indirect hemagglutination assay, but none clinical symptoms. There was no secondary case.