A5100320949- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Fungal Plant Pathogen Control
- Advanced biosensing and bioanalysis techniques
- Plant biochemistry and biosynthesis
- Bioactive Natural Diterpenoids Research
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Fungal Biology and Applications
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Sulfur-Based Synthesis Techniques
- Chemical synthesis and alkaloids
- Vibrio bacteria research studies
- Chemical Synthesis and Analysis
- Chromatography in Natural Products
- Research in Cotton Cultivation
- Electrochemical sensors and biosensors
- Legume Nitrogen Fixing Symbiosis
- Steroid Chemistry and Biochemistry
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
Southwest University
2018-2024
Hebei Medical University
2024
Peking University
2023
Nankai University
2011-2023
Hebei Normal University
2022-2023
Yunnan University
2022
Guangzhou University of Chinese Medicine
2020-2021
Beijing Botanical Garden
2020-2021
South China Botanical Garden
2020-2021
Ocean University of China
2021
Trio of enzymes power divergent synthesis Diterpene natural products are built from a 20-carbon building block, with huge range possible structures and modifications. Chemical specific molecules, some which have valuable biological activities, is tricky because the need for selective oxidations rearrangements when starting widely available scaffolds. Zhang et al. characterized selectivities three oxidative that each attack different positions on common scaffold. They then seamlessly combined...
Abstract A combination of genomic and metabolomic approaches recently resulted in the identification a nonribosomal tetrapeptide tambromycin, which possesses promising antiproliferative activity several unusual structural features, including densely substituted indole, methyloxazoline ring, an pyrrolidine‐containing amino acid called tambroline. In this work, we identify concise synthetic route to access relies on strategic use biocatalytic chemocatalytic C−H functionalization methods...
Urinary tract infections are predominantly caused by uropathogenic Escherichia coli (UPEC). UPEC infects bladder epithelial cells (BECs) via fusiform vesicles, escapes into the cytosol to evade exocytosis, and establishes intracellular bacterial communities (IBCs) for next round of infection. The vesicle escape mechanism remains unclear. Here we show that senses host immune responses initiates upregulating a key phospholipase. phospholipase PldA disrupts membrane, pldA expression is...
Short and sweet: (−)-Isatisine A was constructed using common inexpensive building blocks, such as indole D-ribose (see scheme). The synthesis features an unprecedented intramolecular C glycosylation of oxidative ring contraction. Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: publisher is responsible for content functionality any...
Oxidative coupling and oxidative rearrangement are two of the most common biosynthetic strategies to form diaryl ethers. In contrast, enzymatic ether generation that proceeds in a nonoxidative manner has not been characterized thus far. Here, we discovered versatile thioesterase (TE) domain from nonreducing polyketide synthase (nrPKS) AN7909, which catalyzes formation through series successive steps involving esterification, Smiles rearrangement, hydrolysis. Further mutations biochemical...
Platensimycin (PTM) and platencin (PTN) are potent selective inhibitors of bacterial mammalian fatty acid synthases. The regio- stereospecificity the ether oxygen atom in PTM, which PTN does not have, strongly contribute to selectivity potency PTM. We previously reported biosynthetic origin 11 S,16 S-ether moiety by characterizing diterpene synthase PtmT3 as a (16 R)- ent-kauran-16-ol isolating 11-deoxy-16 R-hydroxylated congeners PTM from Δ ptmO5 mutant. PtmO5, cytochrome P450, was proposed...
Platensimycin (PTM) and platencin (PTN) are highly functionalized bacterial diterpenoids of ent-kauranol ent-atiserene biosynthetic origin. C7 oxidation in the B-ring plays a key role generating structural complexity known for ent-kaurane ent-atisane derived diterpenoids. While all three patterns, α-hydroxyl, β-hydroxyl, ketone, at seen both diterpenoids, their origins remain largely unknown. We previously established that PTM PTN produced by single machinery, featuring cryptic oxidations...
Six new nonadride derivatives, named talarodrides A–F (1–6), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including absolute configurations deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1–4 share a rare caged bicyclo[4.3.1]-deca-1,6-diene with bridgehead olefin maleic anhydride core skeleton, while compounds 5 6 possess first case of naturally occurring 5/7/6 methanocyclonona[c]furan skeleton....
In the present work, a new 3D metal–organic framework (MOF) has been synthesized and characterized.
The acidity of green plum has an important influence on the fruit’s deep processing. Traditional physical and chemical analysis methods for detection are destructive, time-consuming, unable to achieve online detection. In response, a rapid non-destructive method based hyperspectral imaging technology was studied in this paper. Research prediction performance comparisons between supervised learning unsupervised is currently popular. To further improve accuracy component prediction, new system...
A synthetically challenging tetracyclic tertiary amine framework in the Daphniphyllum alkaloid daphenylline was established a six-step sequence featuring an intermolecular Diels–Alder cycloaddition/oxidative aromatization sequence. The utilization of amine–borane complexation strategy is key to successful transformations on our substrates.
Pantoea agglomerans YS19 is an endophytic diazotrophic bacterium isolated from rice. As well as having the ability to form a biofilm, do most bacteria, it characterized by formation of unique multicellular aggregate structure called symplasmata. Indole traditionally known metabolite amino acid tryptophan, which, however, has recently been shown participate in various regulations bacterial physiological processes, including stress resistance, quorum sensing and biofilm formation. Here, indole...
Euphorbia prolifera is a poisonous plant belonging to the Euphorbiaceae family. In this survey on secondary metabolites obtain bioactive substances for development of new antifungal agents agriculture, chemical constituents E. were investigated. This procedure led isolation six and two known diterpenes. Their structures, including absolute configurations, elucidated basis extensive NMR spectroscopic data analyses time-dependent density functional theory ECD calculations. Biological...
Plant architecture and the vegetative-reproductive transition have major impacts on agronomic success of crop plants, but genetic mechanisms underlying these traits in cotton (Gossypium spp.) not been identified. We identify four natural mutations GoCEN-Dt associated with cluster fruiting (cl) early maturity. The situ hybridization shows that GhCEN is preferentially expressed shoot apical meristems (SAM) main stem axillary buds. Constitutive GhCEN-Dt overexpression suppresses vegetative apex...
Abstract 3‐Deoxy‐ d ‐manno‐oct‐2‐ulosonic acid (Kdo) is an eight‐carbon monosaccharide found widely in bacterial lipopolysaccharides (LPSs) and capsule polysaccharides (CPSs). We developed indirect method for the stereoselective synthesis of α ‐Kdo glycosides with a C3‐ p ‐tolylthio‐substituted Kdo phosphite donor. The presence ‐tolylthio group enhanced reactivity, suppressed formation elimination by‐products (2,3‐enes), provided complete ‐stereocontrol. A variety ‐glycosides were...
The first biomimetic total syntheses of natural phloroglucinols tomentosones A and B their analogues have been accomplished. synthetic strategy primarily referred to the potential biosynthetic precursors possible sequence segments assembly by chemological evolution structural entities enabled rapid access titled compounds in a practical fashion.