A5044800762- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Adsorption and biosorption for pollutant removal
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Legume Nitrogen Fixing Symbiosis
- Pharmacological Effects of Natural Compounds
- Statistical Methods in Clinical Trials
- Microbial Metabolites in Food Biotechnology
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Bioactive Compounds and Antitumor Agents
- Nanomaterials for catalytic reactions
- Analytical Chemistry and Chromatography
- Axial and Atropisomeric Chirality Synthesis
- Biochemical effects in animals
- Monoclonal and Polyclonal Antibodies Research
- Chromatography in Natural Products
- Microbial Natural Products and Biosynthesis
- Catalytic Processes in Materials Science
- Medicinal Plants and Bioactive Compounds
- Synthesis of Indole Derivatives
Peking University
2017-2025
Jiangsu Normal University
2021
ABSTRACT The ideal evaluation of diagnostic test performance requires a reference that is free errors. However, for many diseases, obtaining such “gold standard” either impossible or prohibitively expensive. Estimating accuracy in the absence gold standard therefore significant challenge. In this article, we introduce and categorize existing methods evaluating tests without standard, considering factors as type number tests, well structure observed data. For each method, provide...
A novel method for the glycosylation of selenoglycosides activated by iodosylbenzene was developed. The reaction conditions were mild, fast, and efficient, with a high tolerance to diverse protecting groups wide substrate scope, which is advantageous synthesizing complex glycosides. In addition, shown be orthogonal thioglycosides under promotion iodosylbenzene. Notably, yield poorly reactive glucuronidation product obtained acetyl-protected selenoglycoside. Finally, one-pot synthesis β-(1→6)...
Abstract A novel metal‐free allylic C−C σ‐bond cleavage of simple olefins to give valuable cinnamyl aldehydes is reported. 1,2‐Aryl or alkyl migration through bond occurs in this transformation, which assisted by an azide reagent. This method enables O‐atom incorporation into unfunctionalized construct aldehydes. The reaction features hydrocarbon substrates, conditions, and high regio‐ stereoselectivity.
A base-promoted (4 + 2) cyclization of <italic>N</italic>-(<italic>o</italic>-chloromethyl)aryl amides with azlactones was established, which helped construct biologically important dihydroquinolinone frameworks in good yields.
Abstract 3‐Deoxy‐ d ‐manno‐oct‐2‐ulosonic acid (Kdo) is an eight‐carbon monosaccharide found widely in bacterial lipopolysaccharides (LPSs) and capsule polysaccharides (CPSs). We developed indirect method for the stereoselective synthesis of α ‐Kdo glycosides with a C3‐ p ‐tolylthio‐substituted Kdo phosphite donor. The presence ‐tolylthio group enhanced reactivity, suppressed formation elimination by‐products (2,3‐enes), provided complete ‐stereocontrol. A variety ‐glycosides were...
Abstract A tetrasaccharide repeating unit of the O ‐antigen from Escherichia coli O33 has been synthesized for first time using a chemoselective [1+1+2] one‐pot glycan assembly strategy. The phosphoglycerol moiety was installed by phosphoramidite method with benzylidene‐protected glycerol 2‐phosphoramidite as reagent. Overall, target monosaccharide building blocks in 12 linear steps, resulting satisfactory yield 28 %.
Abstract A novel metal‐free allylic C−C σ‐bond cleavage of simple olefins to give valuable cinnamyl aldehydes is reported. 1,2‐Aryl or alkyl migration through bond occurs in this transformation, which assisted by an azide reagent. This method enables O‐atom incorporation into unfunctionalized construct aldehydes. The reaction features hydrocarbon substrates, conditions, and high regio‐ stereoselectivity.
Abstract 3‐Deoxy‐ d ‐manno‐oct‐2‐ulosonic acid (Kdo) is an eight‐carbon monosaccharide found widely in bacterial lipopolysaccharides (LPSs) and capsule polysaccharides (CPSs). We developed indirect method for the stereoselective synthesis of α ‐Kdo glycosides with a C3‐ p ‐tolylthio‐substituted Kdo phosphite donor. The presence ‐tolylthio group enhanced reactivity, suppressed formation elimination by‐products (2,3‐enes), provided complete ‐stereocontrol. A variety ‐glycosides were...