A5100427118- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Aortic aneurysm repair treatments
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Liver Disease Diagnosis and Treatment
- Energy and Environment Impacts
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
- Hybrid Renewable Energy Systems
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Epilepsy research and treatment
- FOXO transcription factor regulation
- EEG and Brain-Computer Interfaces
- Electrocatalysts for Energy Conversion
- Cancer Treatment and Pharmacology
- Kruppel-like factors research
Second Affiliated Hospital of Zhejiang University
2019-2025
Zhejiang University
2017-2025
Shanghai Jiao Tong University
2025
Mudanjiang Medical University
2023-2024
Anhui Medical University
2024
Jilin University
2023
Dalian Medical University
2023
Sir Run Run Shaw Hospital
2017-2023
State Key Laboratory of Clean Energy Utilization
2023
Hangzhou First People's Hospital
2023
Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation lipid peroxidation and involved in various pathophysiological conditions, including cancer. Targeting ferroptosis considered to be novel anti-cancer strategy. The identification FDA-approved drugs as inducers proposed new promising approach for cancer treatment. Despite growing body evidence indicating potential efficacy anti-diabetic metformin an agent, exact mechanism underlying...
Abstract Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation, a newly described form of regulated cell death that may play key role in tumour suppression. In the present study, we investigated expression profiles biological effects fascin actin-bundling protein 1 (Fascin, gene name FSCN1 ) breast cancer. addition, bioinformatics analysis TCGA cancer database gain- loss-of-function studies showed Fascin enhances sensitivity to erastin-induced...
Ubiquitin (Ub), a key player of protein turnover, can be phosphorylated by PINK1 kinase to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and with Parkinson’s disease. However, how is involved neurodegeneration remains elusive. Here we show that elevation pervasive multitude neurodegenerative conditions, including Alzheimer’s disease, aging, ischemic injury. In cultured cells, proteasomal inhibition MG132 leads sPINK1 accumulation,...
To investigate how etiology and seizure localization influence ictal scalp electroencephalographic (EEG) patterns in temporal lobe epilepsy (TLE). We retrospectively analyzed EEG features from 504 focal seizures recorded 189 TLE patients with various etiologies who underwent resective surgery. For onset (SOPs), α/β was more common the low-grade tumor group (38.4%) than hippocampal sclerosis (HS) (14.1%, p < 0.001). The duration shorter compared to cortical dysplasia (FCD), HS, non-specific...
CobB serves as a lysine de-2-hydroxyisobutyrylation enzyme to regulate metabolism and cell growth in prokaryotes.
NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of human breast cancer (BC) cells. The effect FKBP4 appeared to be at protein level since it could not suppress the expression mRNA level. Bioinformatics analysis vitro experiments further demonstrated regulated via regulating nuclear translocation NR3C1. We then reported naringenin, flavonoid, widely...
Mitochondrial dysfunction is a hallmark of beta-amyloid (Aβ)-induced neurotoxicity in Alzheimer's disease (AD), and considered an early event AD pathology. Diammonium glycyrrhizinate (DG), the salt form Glycyrrhizin, known for its anti-inflammatory effects, resistance to biologic oxidation membranous protection. In present study, neuroprotective effects DG on Aβ1–42-induced toxicity potential mechanisms primary cortical neurons were investigated. Exposure 2 µM Aβ1–42 resulted significant...
Abstract Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the most common types medically refractory epilepsy. Deep brain stimulation (DBS) shows considerable promise for treatment TLE. However, optimal targets and parameters DBS to control seizures related impairment are still not fully illustrated. Methods In present study, we evaluated therapeutic potential in medial septum (MS) on function mouse acute chronic models. Results We found that MS...
Abstract The cysteine‐rich lysosomal protein placenta‐specific 8 (PLAC8), also called onzin, has been shown to be involved in many types of cancers, and its role is highly dependent on cellular physiological contexts. However, the precise function PLAC8 breast cancer (BC) progression remains unclear. In this study, we investigated both clinical significance biological functions BC progression. First, high expression was observed primary tissues compared with adjacent normal through...
Ubiquitin (Ub), a key player of protein turnover, can be phosphorylated by PINK1 kinase to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and with Parkinson’s disease. However, how is involved neurodegeneration remains elusive. Here we show that elevation pervasive multitude neurodegenerative conditions, including Alzheimer’s disease, aging, ischemic injury. In cultured cells, proteasomal inhibition MG132 leads sPINK1 accumulation,...