A5100423533- Osteoarthritis Treatment and Mechanisms
- Circadian rhythm and melatonin
- Telomeres, Telomerase, and Senescence
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Exercise and Physiological Responses
- Sleep and related disorders
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Carbon and Quantum Dots Applications
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Chemokine receptors and signaling
- Parasitic Infections and Diagnostics
- T-cell and B-cell Immunology
- Forest, Soil, and Plant Ecology in China
- stochastic dynamics and bifurcation
- Muscle Physiology and Disorders
- Brain Metastases and Treatment
- Autophagy in Disease and Therapy
- Dietary Effects on Health
- Peripheral Artery Disease Management
- interferon and immune responses
Weifang Medical University
2024-2025
University of Cambridge
2024
Gansu Agricultural University
2024
Tianjin University
2021-2023
Xuzhou Medical College
2023
Shandong First Medical University
2019-2023
First Affiliated Hospital of Zhengzhou University
2023
Tianjin Medical University
2018-2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental tolerance catalytic stability. As artificial enzymes, nanozymes can improve the stability, it is still a challenge to achieve high activity. Here, we employed atomic engineering build enzyme named Au24Ag1 clusterzyme that hosts an ultrahigh activity as well strong physiological stability via atom manipulation. The designed activates Ag–S active site lattice expansion oligomer layer, showing antioxidant...
Abstract Near‐infrared‐II (NIR‐II) imaging has shown great potential for monitoring the pathological progression and deep tissue but is limited to present unmet NIR‐II agent. Present fluorophores show a promising prospect imaging, brightness photostability are still highly challenging during real‐time monitoring. In this work, atom‐engineered Au 24 Cd 1 clusters with ultrahigh brightness, stability, developed via single atomic doping. Single atom substitutions contribute 4d state in HOMO...
Abstract Mechanical stress plays a key role in regulating cartilage degradation osteoarthritis (OA). The aim of this study was to evaluate the effects and mechanisms mechanical on articular cartilage. A total 80 male Sprague‐Dawley rats were randomly divided into eight groups ( n = 10 for each group): control group (CG), OA (OAG), CG or OAG subjected low‐, moderate‐, high‐intensity treadmill exercise (CL, CM, CH, OAL, OAM, OAH, respectively). Chondrocytes obtained from knee joints rats; they...
Environmentally persistent organic pollutant (POP) is the general term for refractory compounds that show long-range atmospheric transport, environmental persistence, and bioaccumulation. It has been reported accumulation of POPs could lead to cellular DNA damage adverse effects on metabolic health. To better understand mechanism health risks associated with POPs, we conducted an evidence-based cohort investigation (n = 5,955) at Jinghai e-waste disposal center in China from 2009 2016, where...
Sleep deprivation is reported to cause oxidative stress and hypothesized induce subsequent aging-related diseases including chronic inflammation, Alzheimer's disease, cardiovascular disease. However, how sleep contributes the pathogenesis of deficiency disorder remains incompletely defined. Accordingly, more effective treatment methods for are needed. Thus, better understand detailed mechanism disorder, a mouse model was established by multiple platform method in our study. The accumulation...
Purpose: Sleep is essential for optimal learning across the developmental pathways. This study aimed to (1) explore whether school start and end times screen time influenced sleep disturbances in adolescents during lockdown China (2) investigate if at night sleep-related impairment (daytime fatigue) adolescents' academic performance anxiety levels. Methods: Ninety-nine aged 15–17 years old were recruited from two public schools Baishan City Jilin Province, China. An online questionnaire was...
The aim was to investigate the effects of different frequencies treadmill exercise with total time being constancy on articular cartilage, lipoxin A4 (LXA4) and NF-κB pathway in rat model monosodium iodoacetate-induced osteoarthritis (OA). Fifty male Sprague-Dawley rats were randomly divided into five groups (n = 10): controls (CG), knee OA (OAG), + once daily (OAE1), twice daily, rest interval between exercise>4h (OAE2) three times (OAE3). Rats evaluated after completing program (speed, 18...
Objective: This study aimed to determine whether changes in sleep duration are associated with a higher risk of mild cognitive impairment (MCI) older adults.Results: By the 3-year follow-up, 592 participants developed MCI.Compared individuals who had an unchanged duration, odds ratio (95% confidence interval) for MCI was 1.44 (1.08-1.91)for those whose increased by ≥2 h after multivariate adjustments.Moreover, changing from long moderate, but not short, negatively incidence (odds ratio:...
The aim of the present study was to investigate potential alterations in articular cartilage a rat model monosodium iodoacetate (MIA)‑induced osteoarthritis (OA) with or without treatment moderate treadmill exercise. A total 30 male Sprague‑Dawley rats were randomly divided into three groups (n=10), including control, OA and exercise (OAE) groups. Rats evaluated upon completing program (speed, 18 m/min; min/day; 5 days/week for 4 weeks). Interleukin (IL)‑1β IL‑4 levels serum intra‑articular...
The aim of this study was to examine exercise-related genes in articular cartilage identified through bioinformatics analysis dissect the potential signaling pathway involved mechanical stimulation osteoarthritis (OA). To end, we evaluated GSE74898 dataset from Gene Expression Omnibus database for differentially expressed miRNAs (DE-miRNAs) using R software package and predicted target these miRTarBase. Functional annotation enrichment were performed DE-miRNA targets. effects on tumor...
Currently, there are almost 100 genes related to Alzheimer's disease (AD), and studies have indicated that apolipoprotein E (APO E) ε4 allele is a genetic risk factor of AD. However, been no reports the distributions APO genotypes frequencies in Uighur Han AD patients.We analyzed gene polymorphism 209 cases diagnosed based on National Institute Neurological Communicative Disorders Stroke Disease Related Association 220 non-dementia controls. We used polymerase chain reaction-restriction...
Circadian rhythm disruption leads to dysregulation of lipid metabolism, which further drive the occurrence insulin resistance (IR). Exosomes are natural carrier systems that advantageous for cell communication. In present study, we aimed explore whether and how exosomal microRNAs (miRNAs) in circulation participate modulating skeletal muscle IR induced by circadian disruption. 24-h constant light (12-h light/12-h light, LL) was used establish mouse model Bmal1 interference And clinical...
Cryptosporidiosis is a worldwide zoonotic disease. Oxymatrine, an alkaloid extracted and isolated from the plant bitter ginseng, has been reported to have therapeutic effects on cryptosporidiosis. However, underlying mechanism of its action remains unclear. In this study, we utilized network pharmacology experimental validation investigate oxymatrine in treatment First, potential targets drugs diseases were predicted by TCMSP, Gene Cards, other databases. Following intersection drug-disease...
Opioid-free anesthesia (OFA) can certainly prevent nausea and vomiting after bariatric surgery (BS), but its postoperative analgesic effect is still controversial. Obstructive sleep apnea (OSA) a prominent feature of morbid obesity in BS accounts for very high proportion, which significantly increases the difficulty patients' airway management. Those patients will be more representative highlight advantages OFA. It not clear whether esketamine play role OFA analgesia. Therefore, this study...
Rho-related BTB domain (RhoBTB) proteins belong to Rho guanosine triphosphatases (GTPases). Their putative role implicated in carcinogenesis has been supported by accumulating evidence. However, their expression pattern and potential acute myeloid leukemia (AML) remain unclear. We profiled RHOBTB mRNA via the Gene Expression Profiling Interactive Analysis 2 (GEPIA2) database. Survival analysis was conducted with GEPIA2 UALCAN. Univariate multivariate Cox regression analyses were performed...
The artificial enzymes at the atomic level have shown great potential in chemical biology and nanomedicine, modulation of catalytic selectivity is also critical to application nanozymes. In this work, precision Ag25 clusterzymes protected by single- dual-ligand were developed. Further, activity modulated adjusting doping elements ligand. Ag24Pt1 shows more prominent antioxidant characteristics system, while Ag24Cu1 possesses superoxide dismutase-like (SOD-like) regardless or indicating...
The benefits of IL-35 treatment have been verified in multiple animal models diseases, while its influence on T cells immunity under normal condition still needs to be elucidated. present study was designed investigate the effects modulating levels vivo and vitro cells, response also subsets mice.A plasmid pMSCV-IL-35-GFP carrying mouse linear fragment with two subunits joint together constructed heterodimer expression confirmed. Normal mice were randomly divided into three groups received...
Introduction: IDegLira (brand name Xultophy) is a novel fixed ratio combination of insulin degludec and liraglutide for type 2 diabetes (T2D) patients. This study aimed to investigate the lifetime cost-effective value compared with its single component (Degludec or Liraglutide) explore suitable annual cost if necessary. Methods: UKPDS OM2 was applied determine long-term quality-adjusted life years (QALYs) total costs. The efficacy data that were inputted into model synthesized from 6...