A5081110476- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Effects of Radiation Exposure
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Endoplasmic Reticulum Stress and Disease
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Radiation Therapy and Dosimetry
- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Caveolin-1 and cellular processes
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
- Integrated Circuits and Semiconductor Failure Analysis
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2022
Shenyang Pharmaceutical University
2017-2020
Jinzhou Medical University
2013-2017
First Affiliated Hospital of Liaoning Medical University
2014-2017
China Medical University
2012-2015
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2013
// Wen-feng Gou 1 , Dao-fu Shen Xue-feng Yang Shuang Zhao Yun-peng Liu 2 Hong-zhi Sun Rong-jian Su 3 Jun-sheng Luo and Hua-chuan Zheng Cancer Research Center, Key Laboratory of Brain Spinal Cord Injury Liaoning Province, Animal The First Affiliated Hospital Medical University, Jinzhou, China Department Oncological Medicine, Shenyang, Experimental Correspondence to: Zheng, email: Keywords : gastric cancer, ING5, aggressive phenotypes, progression, carcinogenesis Received January 21, 2015...
Macrophage infiltration and activation is a critical step during acute pancreatitis (AP). NLRP3 inflammasomes in macrophages plays role mediating pancreatic inflammatory responses. Qing-Yi Decoction(QYD)has been used for many years clinical practice of Nankai Hospital combined with traditional Chinese western medicine treatment pancreatitis. Although QYD has well-established efficacy, little known about its bioactive ingredients, how they interact different therapeutic targets the pathways...
The understanding of proliferative and apoptotic changes has aided the improvement diagnosis, treatment prevention gastric cancer. present study aimed to investigate clinicopathological prognostic significance Ki‑67, caspase‑3 p53 in expression levels were evaluated on tissue microarrays carcinomas specimens by immunohistochemistry compared with parameters survival time patients. It was observed that elder or male patients cancer showed overexpression younger female patients, respectively...
// Hua-chuan Zheng 1 , Jing Li 2 Dao-fu Shen Xue-feng Yang Shuang Zhao Ya-zhou Wu Yasuo Takano 3 Hong-zhi Sun Rong-jian Su 4 Jun-sheng Luo Wen-feng Gou Cancer Research Center, Key Laboratory of Brain and Spinal Cord Injury Liaoning Province, Animal The First Affiliated Hospital Medical University, Jinzhou, China Department Gastroenterology, School Health Science, Tokyo University Technology, Ohta-ku, Tokyo, Japan Experimental Correspondence to: Gou, e-mail: xiaogouaeiou@163.com Keywords:...
Beclin 1, an important autophagy-related protein in human cells, is involved autophagy, differentiation, anti-apoptosis, and cancer progression, which increased during periods of cell stress extinguished the cycle. In order to clarify role 1 gastric carcinogenesis subsequent its expression was examined by immunohistochemistry situ hybridization (ISH) on tissue microarrays containing carcinomas, adjacent non-neoplastic mucosa, metastatic lymph node. Gastric carcinoma lines were studied for...
Histone deacetylase inhibitors (HDACi), such as suberoylanilide hydroxamic acid (SAHA), have been shown to act selectively on gene expression, and are potent inducers of growth arrest, differentiation apoptosis in various types cancers vitro vivo. This study aimed elucidate the anti-tumor effects molecular mechanisms SAHA aggressive phenotypes ovarian carcinoma. Two pairs cell lines (SKOV3 SKOV3/DDP; HO8910 HO8910-PM) were exposed treatment, acetyl-Histone H3 H4 expression levels analyzed...
Beclin 1, an important autophagy-related protein in human cells, is involved autophagy, differentiation, anti-apoptosis, and cancer suppression, which increased during periods of cell stress extinguished cycle. Human ovarian tumors display allelic loss 1 with high frequency. To clarify 1's role carcinogenesis subsequent progression, its expression was examined by immunostaining on tissue microarrays containing normal tissue, benign borderline tumors, carcinomas. mRNA carcinoma lines reverse...
RhoC is a small G protein/GTPase and involved in tumor mobility, invasion metastasis. Previously, up-regulated expression found to play an important role ovarian carcinogenesis subsequent progression by modulating proliferation, apoptosis, migration invasion. We transfected RhoC-expressing plasmid siRNA into CAOV3 OVCAR3 cells respectively. These transfectants were exposed vascular epithelial growth factor (VEGF), transforming (TGF)-β1 or their receptor inhibitors with the phenotypes...
Beclin 1 participates in development, autophagy, differentiation, anti- apoptosis, neurodegeneration, tumorigenesis and cancer progression. The roles of colorectal carcinogenesis its subsequent progression are still unclear. Here, the mRNA protein expression were determined carcinoma matched mucosa by Reverse transcriptase-polymerase chain reaction Western blot. Immunohistochemistry situ hybridization (ISH) performed on tissue microarryer with carcinoma, adenoma mucosa. was found to be...
Excessive drinking can damage brain tissue and cause cognitive dysfunction. Studies have found that the early stage of neurodegenerative disease is closely related to heavy drinking. Acetaldehyde (ADE) main toxic metabolite alcohol. However, exact mechanisms ADE-induced neurotoxicity are not fully clear. In this article, we studied cytotoxic effect ADE in HT22 cells primary cultured cortical neuronal cells. We exhibited cytotoxicities against dose-dependent manners. Furthermore, induced...
Due to increased drug and radiation tolerance, there is an urgent need develop novel anticancer agents.In our previous study, we performed a series of structural modifications ursolic acid (UA), natural product pentacyclic triterpenes, found UA232, derivative with stronger anti-tumor activity.In vitro experiments showed that UA232 inhibited proliferation, induced G0/G1 arrest, promoted apoptosis in human breast cancer cervical cells.Mechanistic studies revealed protective autophagy via the...
Cyclin-dependent kinase 19 (CDK19) is overexpressed in prostate cancer, making it an attractive target for both imaging and therapy. Since little known about the optimized approach radioligands of nuclear proteins, linker optimization strategies were used to improve pharmacokinetics tumor absorption, including adjustment length, flexibility/rigidity, hydrophilicity/lipophilicity linkers. Molecular docking was conducted virtual screening followed by IC50 determination. Both BALB/c mice P-16...
BTG (B-cell translocation gene) can inhibit cell proliferation, metastasis, and angiogenesis regulate cycle progression differentiation in a variety of types. We aimed to clarify the role BTG1 ovarian carcinogenesis progression. A BTG1-expressing plasmid was transfected into carcinoma cells their phenotypes related proteins were examined. mRNA expression detected normal tissue (n = 17), benign tumors 12), 64) using real-time RT-PCR. Ectopic resulted lower growth rate, high cisplatin...
Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles RhoA Wnt-5a ovarian carcinoma.RhoA mRNA protein expression normal fallopian tube epithelium, benign tumors, primary carcinomas, metastatic omentum were quantified. or was knocked down OVCAR3 carcinoma cells using siRNAs cell phenotype relevant molecules assayed.RhoA found to be significantly higher than epithelium (p < 0.05), positively associated with...
// Wen-feng Gou 1 , Xue-feng Yang Dao-fu Shen Shuang Zhao Yun-peng Liu 2 Hong-zhi Sun Yasuo Takano 3 Rong-jian Su 4 Jun-sheng Luo and Hua-chuan Zheng Cancer Research Center, Key Laboratory of Brain Spinal Cord Injury Liaoning Province, Animal The First Affiliated Hospital Medical University, Jinzhou, China Department Oncological Medicine, Shenyang, School Health Science, Tokyo University Technology, Ohta-ku, Experimental Correspondence to: Zheng, email: Keywords : gastric cancer, BTG3,...