A5103105700- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Neurological and metabolic disorders
- Anesthesia and Neurotoxicity Research
- Crystallization and Solubility Studies
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Block Copolymer Self-Assembly
- Cancer, Lipids, and Metabolism
- Polymer Surface Interaction Studies
- Effects of Radiation Exposure
- Synthesis of Organic Compounds
- Pancreatic and Hepatic Oncology Research
- Radical Photochemical Reactions
- Optimism, Hope, and Well-being
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Medicinal Plants and Bioactive Compounds
- Advanced Polymer Synthesis and Characterization
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2024-2025
Beijing University of Chemical Technology
2023
Guangzhou Medical University
2021
Dalian University
2021
Affiliated Zhongshan Hospital of Dalian University
2021
Shenyang Pharmaceutical University
2017-2019
Air Force Medical University
2017
China XD Group (China)
2017
Ischemia/reperfusion (I/R) is an inevitable pathophysiological process during heart transplantation, and ferroptosis important pathogenic mechanism. Unlike other modes of cell death, depends on the accumulation iron within oxidative degradation polyunsaturated fatty acids. Dysregulation this pathway has been linked to progression multiple pathological conditions, making it attractive target for therapeutic intervention. Therefore, study aims explore effect I/R transplantation. GEO2R was...
Excessive drinking can damage brain tissue and cause cognitive dysfunction. Studies have found that the early stage of neurodegenerative disease is closely related to heavy drinking. Acetaldehyde (ADE) main toxic metabolite alcohol. However, exact mechanisms ADE-induced neurotoxicity are not fully clear. In this article, we studied cytotoxic effect ADE in HT22 cells primary cultured cortical neuronal cells. We exhibited cytotoxicities against dose-dependent manners. Furthermore, induced...
ABSTRACT Diabetes and myocardial ischemia reperfusion (MIR) injury are characterized by oxidative stress, inflammation, autophagy disorders, cardiac contractile dysfunction. Klotho SIRT1 regulate the level of stress to participate in regulation many physiological functions such as cell survival, aging, apoptosis, autophagy, mitochondrial biogenesis, inflammation. We hypothesized that activation Klotho/SIRT1 signaling pathway could attenuate MIR diabetic rats. Type 1 diabetes model were...
Recreational use of ketamine (KET) has been increasing worldwide. Previous studies have demonstrated that KET induced neurotoxicity; however, few examined how alcohol (ALC) affects KET-induced neurotoxicity. In light the fact some abusers combine with ALC, present study was aimed to investigate effects ALC on neurotoxicity and underlying mechanism in vitro. Our data revealed co-treatment more detrimental cell viability than single treatment both PC12 cells primary cultured rat cortical...
Abstract Directed self‐assembly of materials into patterned structures is great importance since the performance them depends remarkably on their multiscale hierarchical structures. Therefore, purposeful structural regulation at different length scales through crystallization engineering provides an opportunity to modify properties polymeric materials. Here, epitaxy‐directed strategy for regulating pattern including phase structure as well crystal modification and orientation each component...
Some novel α,β-unsaturated aromatic sulfone analogs and Tempol conjugates are prepared evaluated for their radioprotective activity, revealing that the agents have both prophylactic mitigation effects against radiation damage.
OBJECTIVE To investigate the mechanism of antidepressant-like effects Chaihu Guizhi decoction (CGD). at daily dose 17 g/kg and solvent vehicle were administered by gavage in 12 14 male C57BL/6J mice for 7 consecutive days, respectively. Forced swimming test (FST), elevated plus maze (EPM) test, open field (OFT) novelty-suppressed feeding (NSF) performed to assess depression- anxiety-like behaviors motor ability mice. We further used chronic social defeat stress (CSDS) interaction evaluate...
The protection of brain tissue against damage and the reduction infarct size is crucial for improving patient prognosis following ischemic stroke. Therefore, present study aimed to investigate regulatory effect microRNA (miR)‑122 its target gene repressor RNA polymerase III transcription MAF1 homolog (Maf1) on area in Reverse transcription-quantitative PCR (RT‑qPCR) was performed determine miR‑122 expression levels an stroke [middle cerebral artery occlusion (MCAO)] mouse model. Nissl...
Diabetes and myocardial ischemia/reperfusion (MI/R) injury manifest in oxidative stress, inflammation, autophagy disorders cardiac contractile dysfunction. Klotho SIRT1 regulate the level of thus participating regulation many physiological functions such as cell survival, aging, apoptosis, autophagy, mitochondrial biogenesis inflammation. The aim current research was to determine protective effects Klotho/SIRT1 on MI/R type 1 diabetes. Type diabetes is established by intraperitoneal...