A5100356175- Tryptophan and brain disorders
- Circular RNAs in diseases
- Amino Acid Enzymes and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Sphingolipid Metabolism and Signaling
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Calcium signaling and nucleotide metabolism
- Adenosine and Purinergic Signaling
- Ocular and Laser Science Research
- Spinal Cord Injury Research
- Extracellular vesicles in disease
- Electrolyte and hormonal disorders
- Virus-based gene therapy research
- Cholesterol and Lipid Metabolism
- Photosynthetic Processes and Mechanisms
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Neurotoxicity Research
- Pharmacogenetics and Drug Metabolism
Nanjing University of Chinese Medicine
2015-2025
Henan Cancer Hospital
2024
Zhengzhou University
2024
Harbin Medical University
2023
Fifth Hospital In Wuhan
2023
Wuhan University
2023
State Key Laboratory of Medical Neurobiology
2023
China Pharmaceutical University
2023
Allen Institute for Brain Science
2023
Cangzhou Central Hospital
2021
Treatment of chronic spinal cord injury (SCI) is challenging due to cell loss, cyst formation, and the glial scar. Previously, we reported on therapeutic potential a neural progenitor (NPC) chondroitinase ABC (ChABC) combinatorial therapy for SCI. However, source NPCs delivery system required ChABC remained barriers clinical application. Here, investigated directly reprogrammed human biased toward an oligodendrogenic fate (oNPCs) in combination with sustained using innovative affinity...
Despite growing evidence that has declared the importance of circRNAs in neurodegenerative diseases, clinical significance dopaminergic (DA) neuronal degeneration pathogenesis Parkinson disease (PD) remains unclear. Here, we performed rRNA-depleted RNA sequencing and detected more than 10,000 plasma samples PD patients. In consideration ROC correlation between Hohen-Yahr stage (H-Y stage) Unified Disease Rating Scale-motor score (UPDRS) 40 patients,
Background Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 polarization remains elusive. Results novel circular RNA circPOLQ exhibited significantly higher expression CRC tissues than paired normal tissues. Higher was poorer patients CRC. In vitro and vivo experiments showed exosomal did not directly regulate cell...
Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on serotonergic system for drug treatment unsatisfactory shows intractable side effects. Multiple evidence suggests that dopamine (DA) dopaminergic signals associated with neuroinflammation are highly involved in pathophysiology of depression as well mechanism antidepressant drugs, which still early stage study worthy investigation.We...
Parkinson's disease (PD) is a leading neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, contributing to considerable disability worldwide. Current treatments offer only symptomatic relief, highlighting need for novel therapeutic strategies targeting progression. Neuroinflammation plays pivotal role in PD pathogenesis, with NLRP3 inflammasome emerging as key contributor. The virtual screening natural product library comprising 5,088 compounds was...
Glioblastoma (GBM) is the most lethal primary brain tumor with intra-tumoral hierarchy of glioblastoma stem cells (GSCs). The heterogeneity GSCs within GBM inevitably leads to treatment resistance and recurrence. Molecular mechanisms different cellular state remain unclear. Here, we find that classical (CL) mesenchymal (MES) are enriched in reactive immune region high CL-MES signature informs poor prognosis GBM. Through integrated analyses RNA sequencing single-cell datasets, identify...
Abstract SLC1A5 variant (SLC1A5_var) is identified as a mitochondrial glutamine transporter in cancer cells recently. However, the role of SLC1A5_var Parkinson’s disease (PD) completely unknown. Here, we found significant downregulation astrocytes and midbrain mice treated with MPTP/MPP + LPS. Importantly, overexpression ameliorated but knockdown exacerbated - LPS-induced dysfunction. Consequently, provided beneficial effects on PD pathology including improvement PD-like motor symptoms...
Alanine-serine-cysteine transporter 2 (ASCT2) is reported to participate in the progression of tumors and metabolic diseases. It also considered play a crucial role glutamate-glutamine shuttle neuroglial network. However, it remains unclear involvement ASCT2 neurological diseases such as Parkinson's disease (PD). In this study, we demonstrated that high expression plasma samples PD patients midbrain MPTP mouse models positively correlated with dyskinesia. We further illustrated expressed...
The microtubule protein inhibitor C118P shows excellent anti-breast cancer effects. However, the potential targets and mechanisms of in breast remain unknown.Real-time cellular analysis (RTCA) was used to detect cell viability. Apoptosis cycle were detected by flow cytometry. Computer docking simulations, surface plasmon resonance (SPR) technology, microscale thermophoresis (MST) conducted study interaction between alanine-serine-cysteine transporter 2 (ASCT2). Seahorse XF technology measure...
Context: The nephron-protective efficacy of Abelmoschus manihot (Linn.) Medicus (Malvaceae) has been proved by randomized controlled clinical trial.
Abstract Background Preeclampsia (PE) is a serious pregnancy complication. It has been shown that insufficient infiltration of extravillous trophoblasts (EVTs) related to the pathogenesis PE. Circular hsa_circ_0001326 (circ_0001326) uncovered be upregulated in However, influence circ_0001326 on indistinct. Methods 48 pregnant women (25 PE patients and 23 healthy controls) were recruited for this study. Human HTR‐8/Svneo used function analysis. Expression was evaluated by real‐time...
Social adversity not only causes severe psychological diseases but also may improve people’s ability to learn and grow. However, the beneficial effects of social are often ignored. In this study, we investigated whether how affects learning memory in a mouse defeat stress (SDS) model. A total 652 mice were placed experimental groups six 23 each. SDS enhanced spatial, novelty, fear with increased synaptosome associated protein 25 ( SNAP-25) level dendritic spine density hippocampal neurons...
We assessed interactions between the astrocytic volume-regulated anion channel (VRAC) and aquaporin 4 (AQP4) in supraoptic nucleus (SON). Acute SON slices cultures of hypothalamic astrocytes prepared from rats received hyposmotic challenge (HOC) with/without VRAC or AQP4 blockers. In acute slices, HOC caused an early decrease with a late rebound neuronal firing rate vasopressin neurons, which required activity VRAC. also persistent excitatory postsynaptic current frequency, supported by HOC;...
Nerve growth factor (NGF) has been shown to support the survival and differentiation of neurons. In this study, we first developed a retrograde trans-multisynaptic tracer PRV580 expressing mCherry fluorescent protein based on pseudorabies virus Bartha strain map neural circuit sciatic nerve. Secondly, newly was used recovering nerve upon treatment with NGF. Our results showed that red signals from were observed in various brain regions. Among these regions, many areas pyramidal system...
To screen coral-derived compounds with neuroprotective activity and clarify the potential mechanism of lead compounds.The effects were screened by H2 O2 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP+ )-induced cell damage models in SH-SY5Y cells. CCK8 LDH assays used to detect viability. The anti-apoptosis was evaluated flow cytometry. JC-1 MitoSox performed examine changes mitochondrial membrane ROS level. Survival primary cortical dopaminergic midbrain neurons measured MAP2 TH...