A5016364922- MicroRNA in disease regulation
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Electromagnetic Fields and Biological Effects
- Cancer-related gene regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- bioluminescence and chemiluminescence research
- Molecular Biology Techniques and Applications
- Eosinophilic Disorders and Syndromes
- Cancer Cells and Metastasis
- Magnetic and Electromagnetic Effects
- Musculoskeletal synovial abnormalities and treatments
- Carcinogens and Genotoxicity Assessment
- Lipid metabolism and biosynthesis
- Immunodeficiency and Autoimmune Disorders
- Bladder and Urothelial Cancer Treatments
- Connexins and lens biology
- Sinusitis and nasal conditions
- Macrophage Migration Inhibitory Factor
Xinjiang Medical University
2017-2024
First Affiliated Hospital of Zhengzhou University
2020-2024
First Affiliated Hospital of Xinjiang Medical University
2017-2024
Zhengzhou University
2020-2022
China Medical University
2020
Liaoning Cancer Hospital & Institute
2020
Hebei Medical University
2008
Xingtai People's Hospital
2008
Colorectal cancer (CRC) is one of the most common malignant tumours. The recurrence and metastasis CRC seriously affect survival rate patients. Angiogenesis an extremely important cause tumour growth metastasis. Circular RNAs (circRNAs) have been emerged as vital regulators for progression. However, regulatory role, clinical significance underlying mechanisms still remain largely unknown.High-throughput sequencing was used to analyse differential circRNAs expression in non-tumour tissues...
Tumor metastasis is the leading cause of death in patients with colorectal cancer (CRC). Circular RNAs (circRNAs) have been shown to be involved progression. However, regulatory mechanisms circRNAs CRC tumor are currently unknown. Methods: High-throughput sequencing was performed on 6 pairs and adjacent normal tissues identify expression profiles mRNA circRNA. circ1662 assessed by RNA-ISH IHC a tissue chip. The function evaluated knocking down or overexpressing circ1662. MeRIP-qPCR,...
Background Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 polarization remains elusive. Results novel circular RNA circPOLQ exhibited significantly higher expression CRC tissues than paired normal tissues. Higher was poorer patients CRC. In vitro and vivo experiments showed exosomal did not directly regulate cell...
Abstract Background Glycolysis plays an essential role in the growth and metastasis of solid cancer has received increasing attention recent years. However, complex regulatory mechanisms tumour glycolysis remain elusive. This study aimed to explore molecular effect mechanism noncoding RNA miR-103a-3p on colorectal (CRC). Methods We explored effects biological functions CRC cells vitro vivo. Furthermore, we investigated whether regulates HIF1A expression through Hippo/YAP1 pathway, evaluated...
Circular RNAs (circRNAs) regulate gene expression in different malignancies. However, the molecular mechanisms that link circRNAs with tumorigenesis of prostate cancer (PCa) are not well understood. In present study, we attempted to provide a novel basis for targeted therapy PCa from aspect circRNA-microRNA (miRNA)-mRNA interaction. We investigated 5 paired tissues and adjacent non-tumor by microarray analysis. focused on hsa_circ_0005100, which is located chromosome 1 derived FMN2, thus...
The immune microenvironment has profound impacts on the initiation and progression of colorectal cancer (CRC). Therefore, goal this article is to identify two robust subtypes in CRC, further provide novel insights for underlying mechanisms clinical management. In study, CRC were identified using consensus clustering immune-related gene expression profiles meta-GEO dataset (n = 1,198), their reproducibility was verified TCGA-CRC 638). Subsequently, we characterized escape mechanisms,...
Abstract The purpose of this study was to investigate the effects 2.45 GHz microwave (MW) radiation on dimethylhydrazine (DMH)‐induced colon cancer in mice. subjects were 115 Balb/c mice 4 weeks age. animals divided into group A (control), B (DMH), C (DMH + MW), and D [DMH 12‐ O ‐tetradecanoylphorbol‐13‐acetate (TPA)]. Radiation (10 mW/cm 2 ) delivered dorsally with E field parallel mouse's long body axis an anechoic chamber. Radiations administered 3 hr daily, 6 days per week, over a period...
Purpose: Tumor metastasis seriously affects the survival of patients.In recent years, some studies confirmed that long non-coding RNA (lncRNA) played an essential role in tumor progression.A few reported LINC01296 acted as oncogenic regulator cancer.However, its in-depth specific biological mechanism is still unknown.Methods: Real-time quantitative PCR (qPCR) was performed to detect expression and miR-141-3p NSCLC, CRC tissues cell lines, dual luciferase report used evaluate relationship...
Background: At the time of diagnosis, colorectal cancer (CRC) patients are usually in an advanced stage disease, which is accompanied by metastasis. Long noncoding RNAs (lncRNAs) play critical regulatory roles biology. However, contributions lncRNA LINC01272 to CRC remain elusive. Methods: Bioinformatics and survminer R package were used predict intermolecular correlations prognostic indicators. Quantitative real-time PCR was examine molecular expression. In vitro experiments, including...
Abstract Objective This study aimed to investigate whether flow fluid shear stress (FFSS)‐mediated signal transduction affects the function of Piezo1 ion channel in chondrocyte and further explore role mechanical overloading development temporomandibular joint osteoarthritis (TMJ OA). Methods Immunohistochemical staining was used determine expression TMJ OA tissue collected from rat unilateral anterior crossbite (UAC) models. Chondrocytes harvested normal adult SD rats were treated with FFSS...
Exposure to extremely low and frequency electromagnetic fields (ELF LF EMF) has been reported induce potent carcinogenic effects adverse pregnancy outcomes. DNA damage may be an EMF target site. This study investigates both 50 Hz 15.6 kHz magnetic on damagehepair in the normal human amniotic FL cell. The test of unscheduled synthesis (UDS) was utilized. In view weak fields, cells were simultaneously treated with methylnitro-nitrosoguanidine (MNNG), a known carcinogen. exposed sinusoidal...
The aim of this study was to evaluate the effects Ca 2+ , HCO 3 -and BSA on in vitro capacitation-associated protein tyrosine phosphorylation, hyperactivation and acrosome reaction guinea pig sperm.Caudal epididymal sperm were incubated four different groups: modified TALP (Tyrode's albumin lactate pyruvate) or without one medium constituents (Ca BSA).After incubation for required time (0 h, 0.5 1 5 7 h), removed further experiment.The capacitation effect assessed by CTC (Chlortetracycline)...
Abstract Background Glycolysis plays an essential role in the growth and metastasis of solid cancer has received increasing attention recent years. However, complex regulatory mechanisms tumour glycolysis remain elusive. This study aimed to explore molecular effect mechanism noncoding RNA miR-103a-3p on colorectal (CRC). Methods We explored effects biological functions CRC cells vitro vivo . Furthermore, we investigated whether regulates HIF1A expression through Hippo/YAP1 pathway, evaluated...
Objective To explore the clinical characteristics of Immunoglobulin G4 (IgG4) related sialoadenitis, to analyze difference between IgG4 sialoadenitis and Sjogren′ syndrome (SS) summarize treatment method prognosis disease, so as help diagnosis appro-priate treatment. Methods According inclusion criteria exclusione criteria, we collected 12 cases patients 78 SS from First Affiliated Hospital Xinjiang Medical University 2015-2017. The manifestations, laboratory test, pathological...