A5044772105- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatments
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Urinary and Genital Oncology Studies
- Hepatitis B Virus Studies
- Ginseng Biological Effects and Applications
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Phytoestrogen effects and research
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Occupational and environmental lung diseases
- Synthesis and Biological Evaluation
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Vascular Malformations and Hemangiomas
- Heat shock proteins research
China Medical University
2008-2025
Liaoning Cancer Hospital & Institute
2018-2025
Dalian University of Technology
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2022
Key Laboratory of Guangdong Province
2021
Shanxi University of Traditional Chinese Medicine
2021
Sichuan Normal University
2021
First Hospital of China Medical University
2008-2017
Chengdu University of Traditional Chinese Medicine
2017
Hainan Medical University
2016
Circular RNAs (circRNAs) participate in the pathogenesis of various diseases by sponging microRNAs (miRs). However, roles circRNAs remain unreported glomerular diseases. We previously reported that miR-150 positively correlated with renal chronicity index patients lupus nephritis (LN). aimed to investigate circRNA profiling and interaction between LN patients. Six biopsies from untreated female class IV five normal kidney tissues urology were used for sequencing. 171 2-fold differential...
Abstract Nuclear factor kappa-B (NF-κB) activation is a common phenomenon in cancers, which results the aberrant expression of NF-κB target genes and leads to malignant transformation, metastatic dissemination, abnormal cell proliferation or resistance death. Survivin unique member IAP family, well-known cancer-specific molecule molecular marker poor clinical outcome several cancer types, including bladder cancer. YM-155, potent survivin suppressor, has been shown have anti-tumor activity...
Circular RNAs (circRNAs) regulate gene expression in different malignancies. However, the molecular mechanisms that link circRNAs with tumorigenesis of prostate cancer (PCa) are not well understood. In present study, we attempted to provide a novel basis for targeted therapy PCa from aspect circRNA-microRNA (miRNA)-mRNA interaction. We investigated 5 paired tissues and adjacent non-tumor by microarray analysis. focused on hsa_circ_0005100, which is located chromosome 1 derived FMN2, thus...
Gynostemma pentaphyllum (Thunb.) Makino (G. pentaphyllum) is a natural herbal drug that has been widely used to treat many diseases. The antitumor effects of G. were first described in the illustrated catalog plants. Gypenosides are major active components pentaphyllum, and they have reported possess prostate cancer, gastric hepatocellular carcinoma, colon lung breast cancer. However, research on use gypenoside treatment bladder cancer not conducted. In this study, we explored potential...
Abstract The microenvironment of the cancer cell is pivotal to its phenotypic regulation. One central components temperature. An elevation in environmental temperature has been shown increase cell's susceptibility chemo‐ and radiation therapy. goal studies described here was identify some pathways that are modified by a mild cells. Using prostate cells as model system we found addition well anticipated up‐regulation heat shock family proteins, there significant down‐regulation certain...
Abstract Bone metastasis is the most happened metastatic event in prostate cancer (PCa) and needs a large effort treatment. When PCa metastasizes to bone, new microenvironment can induce epigenome reprogramming stemness remodeling of cells, thereby increasing adaptability cells bone microenvironment, this even leads occurrence secondary tumor metastasis. Our group has previously found that RNA binding motif 3 (RBM3) affects stem cell-like properties by interfering with alternative splicing...
721 Background: High recurrence rates plague patients with nonmuscle invasive bladder cancer (NMIBC) following transurethral resection of tumors (TURBT). In response, we have developed a modified TURBT procedure that integrates en bloc resection, endoscopic submucosal dissection, and the injection chemotherapeutic drugs into submucosa (cESD-TURBT).This study aims to determine if cESD-TURBT yields better outcomes than conventional (cTURBT). Methods: This retrospective observational was...
Abstract Stress-response pathways play an important role in cancer. The cold-inducible RNA-binding protein RBM3 is upregulated several types of cancer, including prostate but its pathogenic contributions are undetermined. expressed at low basal levels human fetal or CD133+ epithelial cells (PrEC), compared with the adult CD133-PrEC, and downregulated cultured soft agar exposed to stress. Notably, overexpression cancer attenuated their stem cell-like properties vitro as well tumorigenic...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells through two its receptors: TRAIL-R1 and TRAIL-R2. We investigate the susceptibility human renal cell carcinoma (RCC) to TRM-1 HGS-ETR2, 2 monoclonal agonistic antibodies specific for TRAIL-R2, respectively. HGS-ETR2 effectively induced apoptotic death 10 11 cultures, including RCC lines 9 primary with more pronounced effect after preincubation anti-human IgG Fc. In contrast, was...
Creatine kinase brain (CKB) is one of three cytosolic isoforms creatine that predominantly expressed in the brain. The enzyme overexpressed a wide variety cancers, with exception colon cancer, where it downregulated. significance this downregulation remains poorly understood. Here, we demonstrate overexpression CKB-C283S, dominant-negative construct lacks function but retains its ability to dimerize, causes remarkable changes cell shape, adhesion, and invasion. Furthermore, results increased...
// Xiaolu Cui 1 , Chuize Kong Yuyan Zhu Yu Zeng Zhe Zhang Xiankui Liu Bo Zhan Chiyuan Piao Zhenming Jiang Department of Urology, The First Hospital China Medical University, Shenyang 110001, Liaoning, Correspondence to: Kong, email: kongchuize_cmu@sina.cn Keywords: bladder transitional cell carcinoma, NF-κB, miR-130b, CYLD Received: January 28, 2016 Accepted: May 22, Published: July 06, ABSTRACT Persistent activation NF-κB signaling is closely related to chronic inflammation and...
Abstract OBJECTIVE To elucidate gene expression profiles of lysophosphatidic acid (LPA)‐related molecules in cancer, pre‐cancerous lesion, and benign hyperplasia the prostate. MATERIALS AND METHODS Prostate tissue samples were surgically obtained from 10 patients with localized prostate cancer seven invasive bladder cancer. Cancer cells corresponding stromal normal prostate, high grade intraepithelial neoplasia (HGPIN), hyperplastic glands isolated by laser capture microdissection. mRNA...
There is accumulating evidence suggesting that tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐receptor (R) 2 a promising molecular target for cancer therapy. Therefore, we investigated the effect of chemotherapeutic agents on TRAIL‐R2‐mediated apoptosis and cytotoxicity in various human solid cells. Treatment ACHN renal cell carcinoma (RCC) line with agonistic TRAIL‐R2 antibody (lexatumumab) combination 5‐fluorouracil, vinblastine, paclitaxel, or docetaxel did not overcome...
The traditional herbal compound Danggui Buxue decoction (DBD), has long been used for the prevention and treatment of cardiovascular diseases, however, underlying molecular mechanism its effect remains still unknown. So this study would to investigate DBD on cardiac damage induced by myocardial infarction (MI) challenge.SD Rats with ligation left anterior descending (LAD) coronary artery were randomly divided into MI, MI plus Betaloc Zok, high dose, low dose group, together sham-operated...
Paclitaxel frequently serves as the first-line chemotherapeutic agent for castration-resistant prostate cancer (PCa) patients. However, acquired paclitaxel-resistance almost always occurs after initial responses, and mechanisms by which this remain largely unknown. The goal of present study was to identify differentially expressed protein(s) associated with further explore potential involved in drug resistance. By comparing nuclear matrix protein (NMP) patterns DU145-TxR cells, previously...
Long non-coding RNAs (lncRNAs) play important regulatory roles in hepatocellular carcinoma (HCC). However, the function of LOC107985656 HCC progression remains unclear. The lncRNA, mRNA and miRNA levels tissues or cells were measured using real-time quantitative polymerase chain reaction (RT-qPCR). proliferation cancer was evaluated 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) viability colony formation assays. Bioinformatics prediction, dual luciferase assay RNA...
Abstract BACKGROUND Cysteine‐rich angiogenic inducer 61 (Cyr61) is an extracellular matrix protein involved in the transduction of growth factor and hormone signaling. Previously, we demonstrated that Cyr61 was highly expressed prostate cancer (PCa) but expression levels were associated with a lower risk PCa recurrence. In present study, demonstrate serum potential biomarker correlates aggressiveness. Furthermore, also explore mechanism underlying changes during progression. METHODS...