A5078085024- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Renal and related cancers
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Research Studies
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Cancer Cells and Metastasis
First Hospital of China Medical University
2012-2024
China Medical University
2014-2024
Hong Kong Polytechnic University
2024
Wenzhou Medical University
2024
ShanghaiTech University
2024
The First People’s Hospital of Lianyungang
2024
Xian Yang Central Hospital
2024
Heilongjiang Provincial Hospital
2022
University of Electronic Science and Technology of China
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Modulation of immune/inflammatory responses by diverse strategies including amyloid-β (Aβ) immunization, nonsteroidal anti-inflammatory drugs, and manipulation microglial activation states has been shown to reduce Alzheimer's disease (AD)-like pathology cognitive deficits in AD transgenic mouse models. Human umbilical cord blood cells (HUCBCs) have unique immunomodulatory potential. We wished test whether these might alter AD-like after infusion into the PSAPP model AD. Here, we report a...
Converging lines of evidence indicate dysregulation the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD). We report that transgenic mice overproducing amyloid-β peptide (Aβ) but deficient ( PSAPP/CD45 −/− mice) faithfully recapitulate AD neuropathology. Specifically, we find increased abundance cerebral intracellular and extracellular soluble oligomeric insoluble Aβ, decreased plasma microglial neurotoxic cytokines tumor necrosis...
The effect of competing endogenous RNA (ceRNA) can regulate gene expression by competitively binding microRNAs. Fascin-1 (FSCN1) plays an important role in the regulation cellular migration and invasion during tumor progression, but how its regulatory mechanism works through ceRNA is still unclear bladder cancer (BLCA).The fascin-1, miR-200b, ZEB1-AS1 BLCA was investigated vitro vivo. interaction between identified using bioinformatics analysis, luciferase activity assays, RNA-binding...
Clear cell renal carcinoma (ccRCC) is an extremely common kind of kidney cancer in adults.Immunotherapy and targeted therapy are particularly effective at treating ccRCC.In this study, weighted gene co-expression network analysis a deconvolution algorithm that quantifies the cellular composition immune cells were used to analyze ccRCC expression data from Gene Expression Omnibus database, identify modules related CD8 + T cells.Ten hub genes (LCK, CD2, CD3D, CD3G, IRF1, IFNG, CCR5, CD8A,...
Background Bladder cancer is the most common malignancy of urinary system. However, patient prognosis and treatment outcomes in bladder are difficult to predict owing high tumor heterogeneity. Given that abnormal glutamine metabolism has been identified as a key factor driving progression cancer, it necessary assess therapeutic efficacy treatments based on an analysis metabolism-related genes. Methods We used sample data downloaded from The Cancer Genome Atlas identify genes prognostic...
Background Bladder cancer (BCa) is a common malignancy of the urinary tract. Due to high heterogeneity BCa, patients have poor prognosis and treatment outcomes. Immunotherapy has changed clinical landscape for many advanced malignancies, opening new avenues precise malignancies. However, effective predictors models guide predict immunotherapeutic outcomes are still lacking. Methods We downloaded BCa sample data from The Cancer Genome Atlas identify anti-PD-L1 immunotherapy-related genes...
Spontaneous regression of neuroblastoma (NB) resembles the developmentally regulated programmed cell death (PCD) sympathetic neurons. Regressing tumor cells express high levels nerve growth factor (NGF) receptors TRKA and p75NTR are dependent on NGF for survival; however, underlying molecular mechanism remains elusive. Here, we show that UNC5D, a dependence receptor is directly targeted by p53 family members, highly expressed in favorable NBs. withdrawal strongly upregulated E2F1, human...
BACKGROUND:Cancer immunotherapy is the use of immune system to treat cancer. After years research, there have been a significant number publications in this field. We analyzed literature and performed hotspot analysis identify important areas future scientific research. MATERIAL AND METHODS:Articles (2945) related cancer published past 3 were selected as research sample. BICOMB software was then used retrieve high-frequency words construct text/co-word matrix. Next, gCLUTO analyze matrix by...
Abstract Background Chemo-resistance of bladder cancer has been considered to be one the serious issues solved. In this study, we revealed pivotal role miR-424 in regulation CDDP sensitivity cells. Methods The cytotoxicity cisplatin and effect were assessed by flow cytometry TUNEL. Transcriptional HIF-1α was Chromatin immunoprecipitation (ChIP). Effect on expression UNC5B , SIRT4 (Sirtuin4) apoptotic markers measured QRT-PCR and/or Western blot. for tested luciferase reporter assay....
// Xiaolu Cui 1 , Chuize Kong Yuyan Zhu Yu Zeng Zhe Zhang Xiankui Liu Bo Zhan Chiyuan Piao Zhenming Jiang Department of Urology, The First Hospital China Medical University, Shenyang 110001, Liaoning, Correspondence to: Kong, email: kongchuize_cmu@sina.cn Keywords: bladder transitional cell carcinoma, NF-κB, miR-130b, CYLD Received: January 28, 2016 Accepted: May 22, Published: July 06, ABSTRACT Persistent activation NF-κB signaling is closely related to chronic inflammation and...
Aberrant expression of long noncoding RNAs (lncRNAs) is associated with cancer tumorigenesis and progression. It has been suggested that lncRNAs may be potential clinical diagnostic prognostic biomarkers, therapeutic targets. In the present study, levels small nucleolar RNA host gene 15 (SNHG15) were significantly upregulated in renal cell carcinoma (RCC) tissues lines compared adjacent a proximal tubule epithelial line, as determined by reverse transcription‑quantitative polymerase chain...
Abstract Recent cancer studies have found that the netrin family of proteins plays vital roles in development some cancers. However, functions many variants these remain incompletely understood. In this work, we used most comprehensive database available, including more than 10000 samples across 30 tumor types, to analyze six members family. We performed analysis genetic change and expression genes analyzed epigenetic pathway relationships, as well correlation with drug sensitivity. Although...
Abstract Background Bladder cancer is the tenth most common globally, but existing biomarkers and prognostic models are limited. Method In this study, we used four bladder cohorts from The Cancer Genome Atlas Gene Expression Omnibus databases to perform univariate Cox regression analysis identify genes. We least absolute shrinkage selection operator construct a model. Kaplan–Meier analysis, receiver operating characteristic curve, univariate/multivariate were evaluate Finally, co-expression...
Alzheimer's Disease (AD) is the most common age-related dementia, with a current prevalence in excess of five million individuals United States. The aggregation amyloid-beta (A beta) into fibrillar amyloid plaques key pathological event development disease. Microglial proinflammatory activation widely known to cause neuronal and synaptic damage that correlates cognitive impairment AD. However, pharmacological attempts at reducing neuroinflammation mediated via microglial have been largely...
Abstract In light of the increasing incidence renal cell carcinoma (RCC), its molecular mechanisms have been comprehensively explored in numerous recent studies. However, few studies focus on influence multi‐factor interactions during occurrence and development RCC. This study aims to investigate quantitative global proteome changes lysine succinylation related proteins, seeking facilitate a better understanding underlying LC‐MS/MS combined with bioinformatics analysis are used...