A5100660688- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Functional Brain Connectivity Studies
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- RNA Research and Splicing
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Inflammatory mediators and NSAID effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bladder and Urothelial Cancer Treatments
- Kawasaki Disease and Coronary Complications
- Proteoglycans and glycosaminoglycans research
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging and Pathology Studies
- Synthesis of heterocyclic compounds
Capital Medical University
2011-2025
Shanghai Jiao Tong University
2021-2024
China Medical University
2014-2023
North China Electric Power University
2023
Xinxiang Medical University
2018-2023
Obstetrics and Gynecology Hospital of Fudan University
2022-2023
The University of Texas Health Science Center at Tyler
2019-2023
First Hospital of China Medical University
2023
Huazhong Agricultural University
2023
Shanghai Medical College of Fudan University
2022-2023
Abstract Dementia causes a substantial global economic burden, but effective treatment is lacking. Recently, studies have revealed that gamma-band waves of electrical brain activity, particularly 40 Hz oscillations, are closely associated with high-order cognitive functions and can activate microglia to clear amyloid-β deposition. Here, we found compared sham stimulation, applying 40-Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) over the bilateral angular gyrus in...
The transcription factor ZNF143 contains a central domain of seven zinc fingers in tandem array and is involved 3D genome construction. However, the mechanism by which functions chromatin looping remains unclear. Here, we show that directionally recognizes diverse range genomic sites directly within enhancers promoters required for between these sites. In addition, located CTCF cohesin at numerous sites, removal narrows space cohesin. Moreover, genetic deletion ZNF143, conjunction with acute...
Importance Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome children (MIS-C). The lack vaccine safety data this unique population may cause hesitancy and concern for many families health care professionals. Objective To describe following MIS-C. Design, Setting, Participants In multicenter cross-sectional study including 22 North American centers participating National Heart, Lung, Blood Institute,...
Abstract Interest in the pathophysiological role of IgG fragment crystallizable (Fc) N-linked glycosylation arose from changes humoral immune responses. In this study, circulating disease-specific (DSIgG) derived serum immunoinflammation-related protein complexes was isolated 846 samples 443 patients with benign gastric diseases (BGDs) and 403 cancer (GC), DSIgG glycopeptides attached to Fc region at site Asn297 were analyzed using matrix-assisted laser desorption/ionization- Fourier...
Aim: Prostate cancer (PCa) is the most common malignancy found in males worldwide. Although it mostly indolent, PCa still poses a serious threat to long-term health. Materials & methods: The Cancer Genome Atlas data were randomly divided into training and validation groups. Least absolute shrinkage selection operator regression on DNA methylation group was conducted build model, which validated group. Weighted correlation network analysis RNA-seq identify therapy target. Functional (western...
Enhancers generate bidirectional noncoding enhancer RNAs (eRNAs) that may regulate gene expression. At present, the eRNA function remains enigmatic. Here, we report a 5′ capped antisense PEARL ( Pcdh associated with R-loop formation) is transcribed from protocadherin ) α HS5-1 region. Through loss- and gain-of-function experiments CRISPR/Cas9 DNA fragment editing, CRISPRi, CRISPRa, as well locked nucleic acid strategies, in conjunction ChIRP, MeDIP, DRIP, QHR-4C, HiChIP experiments, found...
On December 7, 2022, China's National Health Commission issued the Ten New Covid Rules lifting dynamic zero-COVID policy. In interim, vaccination campaigns continue to be promoted. We assessed potential impacts on status, perceptions, and attitudes toward COVID-19 vaccines via an online self-administered questionnaire. Among 1,170 participants, 1,142 (97.6%) participants were vaccinated against COVID-19, 51.8% (591/1,142) have already received booster. More than half of who ages 31 50...
The inability to intraoperatively distinguish primary tumor, as well lymphatic spread, increases the probability of positive surgical margins, tumor recurrence, and toxicity. goal this study was develop a tumor-specific optical probe for real-time fluorescence-guided surgery.A humanized antibody fragment against PSCA (A11 minibody, A11 Mb) conjugated with near-infrared fluorophore, IRDye800CW. integrity binding were confirmed by gel electrophoresis, size-exclusion chromatography, flow...
APOBEC3B (A3B), a member of the APOBEC family cytidine deaminases, has been gradually regarded as key cancerous regulator. However, its expression and mechanism in cervical cancer (CC) have not fully elucidated. This study was to investigate pattern potential on cell cycle, well HPV oncogenes CC.Data from The Cancer Genome Atlas (TCGA) Gene Expression (GEO) were used indicate mRNA A3B cancer. Western blot assay detect levels SiHa Hela lines. Immunohistochemistry (IHC) explore protein...
Recent evidence suggests that the cerebellum is related to motor and non-motor cognitive functions, several coupled cerebro-cerebellar networks exist, including links with limbic network. Since structures are affected by Alzheimer pathology, even in preclinical stages of Alzheimer's disease (AD), we aimed investigate cerebral network activity from perspective cerebellum. Twenty patients mild impairment (MCI), 18 AD, 26 healthy controls (HC) were recruited acquire Resting-state functional MRI...
Clarifying the intrinsic mechanisms of acupuncture’s clinical effects has recently been gaining popularity. Here, we choose Siguan acupoint (a combination bilateral LI4 and Liv3) its sham point to evaluate multiacupoint specificity. Thirty‐one healthy volunteers were randomly divided into real (21 subjects) (10 groups. Our study used a single block experimental design avoid influence posteffects. Functional magnetic resonance imaging data acquired during acupuncture stimulation. Results...
The aim of the present study was to determine potential core genes in pathogenesis human thoracic aortic dissection (TAD) by analyzing microarray profiles long non‑coding (lnc)‑RNAs between TAD and normal aorta (NTA). differentially expressed lncRNA tissues patients (TAD group, n=6) age‑matched donors with diseases (NTA were analyzed lncRNAs microarray. Gene ontology (GO), pathway network analyses used further investigate candidate mRNAs. Differentially mRNAs validated reverse...
Paclitaxel frequently serves as the first-line chemotherapeutic agent for castration-resistant prostate cancer (PCa) patients. However, acquired paclitaxel-resistance almost always occurs after initial responses, and mechanisms by which this remain largely unknown. The goal of present study was to identify differentially expressed protein(s) associated with further explore potential involved in drug resistance. By comparing nuclear matrix protein (NMP) patterns DU145-TxR cells, previously...
Paclitaxel plays a pivotal role in the chemotherapy of breast cancer, but resistance to this drug is an important obstacle treatment. It reported that microRNA-152-3p (miR-152-3p) involved tamoxifen whether it paclitaxel cancer remains unknown.