A5081978191- Kawasaki Disease and Coronary Complications
- Genetic factors in colorectal cancer
- Congenital Heart Disease Studies
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Coronary Artery Anomalies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Estrogen and related hormone effects
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Cardiovascular Conditions and Treatments
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Non-Invasive Vital Sign Monitoring
- Blood groups and transfusion
- ECG Monitoring and Analysis
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Cardiac Valve Diseases and Treatments
Seattle Children's Hospital
2020-2024
University of Washington
2020-2024
University of Southern California
2021
Children's Hospital of Los Angeles
2018-2021
Health First
2018
Center for Cancer and Blood Disorders
2016
George Washington University
2016
Children's National
2016
Israel Cancer Association
2012
Tel Aviv Sourasky Medical Center
2006-2011
CD24 is a potential oncogene reported to be overexpressed in large variety of human malignancies. We have shown that 90% colorectal tumors at fairly early stage the multistep process carcinogenesis. Anti-CD24 monoclonal antibodies (mAb) induce significant growth inhibition and pancreatic cancer cell lines express protein. This study designed investigate further effects down-regulation using mAb or small interfering RNA vitro vivo. Western blot analysis showed anti-CD24 induced protein...
<i>Background:</i> Multiple studies have indicated that specific COX-2 inhibitors may prevent CRC. However, the long-term use of is not toxicity-free and be limited due to its cardiovascular side effects. The present study was carried out examine chemopreventive effects celecoxib curcumin alone in combination using 1,2-dimethylhydrazine (DMH) rat model. <i>Methods:</i> Male rats were injected with DMH randomly divided into four groups consumed one following diets: (a)...
Chronic transfusion therapy (CTT) is indicated for stroke prevention in children with sickle cell anemia (SCA) and complicated by iron overload alloimmunization. CTT performed simple (ST), partial manual exchange (PME), or erythrocytapheresis (RCE). Although small case series have demonstrated RCE combination chelation stabilizes and/or decreases ferritin, there are no reports comparing the effect of ST, PME, on liver concentration (LIC). modality serum ferritin LIC were compared SCA...
Importance Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome children (MIS-C). The lack vaccine safety data this unique population may cause hesitancy and concern for many families health care professionals. Objective To describe following MIS-C. Design, Setting, Participants In multicenter cross-sectional study including 22 North American centers participating National Heart, Lung, Blood Institute,...
Chronic transfusion therapy (CTT) for sickle cell disease (SCD) reduces morbidity by suppressing the amount of circulating hemoglobin S (HbS)-containing red blood cells (RBC). The effectiveness CTT depends on rate RBC clearance. Glucose-6-phosphate dehydrogenase (G6PD) deficient donor may exhibit increased hemolysis, but it is unknown if these units results in less effective outcomes SCD. Children with SCD were followed prospectively multiple transfusions. G6PD activity transfused was...
Abstract The adenomatous polyposis coli or β-catenin genes are frequently mutated in colorectal cancer cells, resulting oncogenic activation of signaling. We tried to establish vitro and vivo models for selectively killing human cells with an activated β-catenin/T-cell factor (Tcf) pathway. used a recombinant adenovirus that carries lethal gene [p53-up-regulated modulator apoptosis (PUMA)] under the control β-catenin/Tcf–responsive promoter (AdTOP-PUMA) target (SW480, HCT116, DLD-1, LS174T),...
We report treating a term neonate with tuberous sclerosis and giant rhabdomyomas who presented incessant supraventricular tachycardia Everolimus. The treatment was efficient in reducing tumor size assisted as an adjunct therapy controlling arrhythmia limiting preexcitation. Treatment challenged by difficulty to achieve stable drug level limited neutropenia serious side effect.
Abstract BACKGROUND. Functional activation of β‐catenin/T‐cell factor (Tcf) signaling plays an important role in the early events carcinogenesis. Recently, it was demonstrated that adenomatous polyposis coli or β‐catenin genes are mutated frequently gastric cancer cells. The objective current study to use a gene‐targeting approach kill human cells selectively with activated β‐catenin/Tcf signaling. METHODS. A recombinant adenovirus carries lethal gene (p53 up‐regulated modulator apoptosis...
Tetralogy of Fallot (ToF) with pulmonary atresia (ToF-PA) is a complex congenital heart defect at the extreme end spectrum ToF, no antegrade flow into arteries. Patients differ regard to sources blood flow. In milder disease, there are confluent branch arteries fed by ductus arteriosus. more severe cases, however, arteriosus absent, and sole source via major aortopulmonary collateral (MAPCAs). The variability in origin, size, number, clinical course these MAPCAs adds complexity patients....
Abstract Background: Direct oral anticoagulants have the potential to improve care in children requiring chronic anticoagulation. Edoxaban has favourable pharmacokinetics that could benefit younger patients but data on long-term safety and efficacy for specific paediatric indications are lacking. Study Aims: We present a single-centre experience using edoxaban who require anticoagulation large coronary artery aneurysms secondary Kawasaki disease. Methods: Weight-based dosing of once-daily...
Abstract Purpose: Cyclooxygenase-2 inhibitor (celecoxib, Pfizer) is a promising chemopreventive agent, yet its long-term use may be limited due to increased cardiovascular toxicity. This study was aimed identify genes and pathways involved in colorectal tumorigenesis affected by celecoxib. Experimental Design: Normal rat enterocytes (IEC18 cells) their Ras-transformed derivatives (R1) were exposed for 72 h or over 6 months celecoxib analyzed gene expression pattern using Genechip (RG-U34)....
Bak is a pro-apoptotic gene, which plays an important role in the multi-step process of gastrointestinal tumorigenesis. We hypothesized that downregulation expression normal enterocytes will result transformed phenotype. The nontumorigenic intestinal epithelial cell line (IEC18) was transfected with vector pMV12-AS-bak (encoding anti-sense bak). Three clones, protein levels similar to those seen colon cancer lines and significantly lower than found parental cells, were further evaluated....
<i>Background:</i> The Cox-2 inhibitor, celecoxib (Pfizer Inc., N.Y., USA), is a promising chemopreventive agent [Arber et al.: N Engl J Med 2006;355:885–895; Bertagnolli 2006;355:873–884]. This study aims to explore its mechanism by defining changes in gene expression between neoplastic and normal tissue samples before after treatment. <i>Methods:</i> Patients with documented colorectal neoplasia screening colonoscopy, destined undergo surgical colectomy, were...
The Etanercept as Adjunctive Treatment for Acute Kawasaki Disease, a phase-3 clinical trial, showed that etanercept reduced the prevalence of IVIg resistance in acute disease. In patients who presented with coronary artery involvement, it maximal size and short-term progression dilation. Following up this patient group, we evaluated potential long-term benefit disease.Patients were followed at least 1 year after trial. dilated arteries (z-score ≥ 2.5) was measured each follow-up visit....