A5002563445- Ferroptosis and cancer prognosis
- Food Chemistry and Fat Analysis
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Natural Compound Pharmacology Studies
- RNA modifications and cancer
- S100 Proteins and Annexins
- Genetic Associations and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Tissue Engineering and Regenerative Medicine
- Monoclonal and Polyclonal Antibodies Research
- Autophagy in Disease and Therapy
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- African Botany and Ecology Studies
- Proteins in Food Systems
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Biochemical Analysis and Sensing Techniques
State Key Laboratory of Food Science and Technology
2023-2025
Jiangnan University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Peking Union Medical College Hospital
2023
China Medical University
2020-2021
First Hospital of China Medical University
2020
Abstract The existence of breast cancer stem cells (BCSCs) is a major reason underlying metastasis and recurrence after chemotherapy radiotherapy. Targeting BCSCs may ameliorate relapse therapy resistance. Here we report that expression the pseudokinase Tribble 3 (TRIB3) positively associates with stemness progression. Elevated TRIB3 supports by interacting AKT to interfere FOXO1-AKT interaction suppress FOXO1 phosphorylation, ubiquitination, degradation E3 ligases SKP2 NEDD4L. accumulated...
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis. However, how aberrant autophagy promotes fibrosis far from understood. Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for stress protein TRIB3 (tribbles pseudokinase 3)-mediated dysfunction. Human fibrotic liver tissues were obtained patients with cirrhosis who underwent an open surgical repair process. The functional implications evaluated mouse models induced by bile duct...
Mangosteen seed fat (MSF), a novel tropical fat, predominantly comprises 1,3-distearoyl-2-linoleoyl-glycerol (StLSt) and 1,3-distearoyl-2-oleoyl-glycerol (StOSt). The was blended with cocoa butter (CB) in proportions of 5%, 25% 60% the present study, binary blends achieved acceptable miscibility. It indicated that StLSt could be mixed well symmetrical monounsaturated triacylglycerols CB, especially StOSt, 1-palmitoyl-2-oleoyl-3-stearoyl-glycerol (POSt) 1,3-dipalmitoyl-2-oleoyl-glycerol...
Aim: Prostate cancer (PCa) is the most common malignancy found in males worldwide. Although it mostly indolent, PCa still poses a serious threat to long-term health. Materials & methods: The Cancer Genome Atlas data were randomly divided into training and validation groups. Least absolute shrinkage selection operator regression on DNA methylation group was conducted build model, which validated group. Weighted correlation network analysis RNA-seq identify therapy target. Functional (western...
Capsular contracture is a prevalent and severe complication that affects the postoperative outcomes of patients who receive silicone breast implants. At present, prosthesis replacement major treatment for capsular after both augmentation procedures reconstruction following cancer surgery. However, mechanism(s) underlying remains unclear. This study aimed to identify biological features reveal potential mechanism using RNA sequencing. Sample tissues from 12 female (15 capsules) were divided...
Abstract SOS‐rich fats have been developed to improve heat stable properties and fat bloom‐resistant abilities of chocolates, which is highly connected with their crystallization behaviors. Shea butter stearin (SBS) mango kernel (MKF) are the typical fats. Both contained high levels stearic acid (45.06%–59.67%) oleic (31.85%–39.97%), while 77.00%–86.88% were distributed at sn ‐2 positions triacylglycerol molecules, contributing forming 78.04% SOS in SBS 47.85% MKF. Their significantly higher...
Monoclonal antibodies (mAbs) are widely used in many fields due to their high specificity and ability recognize a broad range of antigens. IL-17A can induce rapid inflammatory response both alone synergistically with other proinflammatory cytokines. Accumulating evidence suggests that therapeutic intervention signaling offers an attractive treatment option for autoimmune diseases cancer. Here, we present combinatorial approach optimizing the affinity thermostability novel anti-hIL-17A...
Abstract Background Skin cutaneous melanoma (SKCM) is one of the most highly prevalent and complicated malignancies. Glycolysis cholesterogenesis pathways both play important roles in cancer metabolic adaptations. The main aims this study are to subtype SKCM based on glycolytic cholesterogenic genes build a clinical outcome predictive algorithm subtypes. Methods A dataset with 471 specimens was downloaded from Cancer Genome Atlas (TCGA) database. We extracted clustered Molecular Signatures...
Background Prostate cancer (PC) is the most common non-cutaneous malignancy among men in western world. However, heterogeneity remains a pressing clinical problem.Research design and methods The least absolute shrinkage selection operator (LASSO) was used to screen prognostic signature. Weighted correlation network analysis (WGCNA) identify target genes associated with high-risk characteristics. Gene set enrichment suggest molecular mechanism of MYBL2 PC. In addition, vitro experiments were...
Regeneration and tumorigenesis are indicated as related processes, while regeneration leads to life the outcome of is death. Here, we show upregulation zfp281 (zinc finger 281) in our adipose de novo model through RNA-seq analysis. Then, validated via immunofluorescence. Following that, found that ZNF281 (the human homolog Zfp281) was upregulated most types cancer worse prognosis 10 tumors. We further investigated role cervical squamous cell carcinoma endocervical adenocarcinoma (CESC),...