A5100431441- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Plant-Microbe Interactions and Immunity
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- RNA Research and Splicing
- Plant Pathogens and Fungal Diseases
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Muscle Physiology and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Bone and Dental Protein Studies
- Heat shock proteins research
- Plant Pathogenic Bacteria Studies
- RNA and protein synthesis mechanisms
- dental development and anomalies
- Asymmetric Synthesis and Catalysis
Guizhou Academy of Sciences
2023-2025
Jilin University
2025
Model Animal Research Center
2025
South College
2024-2025
Tianjin Medical University
2013-2024
First Affiliated Hospital of Dalian Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Shanxi Academy of Agricultural Sciences
2024
Shanxi Agricultural University
2024
Hainan Normal University
2022-2024
Abstract The existence of breast cancer stem cells (BCSCs) is a major reason underlying metastasis and recurrence after chemotherapy radiotherapy. Targeting BCSCs may ameliorate relapse therapy resistance. Here we report that expression the pseudokinase Tribble 3 (TRIB3) positively associates with stemness progression. Elevated TRIB3 supports by interacting AKT to interfere FOXO1-AKT interaction suppress FOXO1 phosphorylation, ubiquitination, degradation E3 ligases SKP2 NEDD4L. accumulated...
Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important mechanisms of atrial remodeling, predisposing to the development fibrillation (AF) in type 2 diabetes mellitus (T2DM). However, molecular underlying these processes especially their interactions have not been fully elucidated.To explore potential role ER stress-mitochondrial oxidative remodeling AF induction diabetes.Mouse cardiomyocytes (HL-1 cells) rats with T2DM were used as study models. Significant was...
Background Previous research has found a link between dietary factors and asthma. However, few studies have analyzed the relationship asthma using Mendelian randomization. Methods: The IEU Open GWAS project ( https://gwas.mrcieu.ac.uk/ ) was source of exposure outcome datasets. datasets included Alcoholic drinks per week, Alcohol intake frequency, Processed meat intake, Poultry Beef Non-oily fish Oily Pork Lamb/mutton Bread Cheese Cooked vegetable Tea Fresh fruit Cereal Salad/raw Coffee...
The ability of proteins to locate specific targets among a vast excess nonspecific DNA is fundamental theme in biology. Basic principles governing these search mechanisms remain poorly understood, and no study has provided direct visualization single searching for engaging target sites. Here we use the postreplicative mismatch repair MutSα MutLα as model systems understanding diffusion-based searches. Using single-molecule microscopy, directly visualize it searches lesions, lesion-bound...
Female fertility irreversibly declines with aging, and this is primarily associated the decreased quality quantity of oocytes. To evaluate whether a long-term melatonin treatment would improve aged mice, different concentrations (10-3 , 10-5 10-7 mol/L) were supplemented into drinking water. Melatonin treatments improved litter sizes mice at age 24 weeks. Mice treated mol/L had largest size among other concentrations. At optimal concentration, not only significantly increased total number...
Abstract High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy resistance across cancer types, including non-small cell lung (NSCLC). EGFR tyrosine kinase inhibitors (TKIs) are first-line for NSCLC. However, patients eventually deteriorate after inevitable acquisition TKI-resistant mutations, highlighting the need therapeutics with alternative mechanisms action. Here, we report that elevated tribbles pseudokinase 3...
Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres genome-wide. We previously showed binds disrupts G-quadruplex (G4) in vitro, suggesting may prevent vivo blocks to by resolving G4 structures. Here, we demonstrate unfolds similar efficiency RPA. In cells, recruited telomeric non-telomeric chromatin upon stabilization, even when ATR/ATM pathways were inhibited. STN1 depletion increases...
Abstract Dysregulated maternal nutrition, such as vitamin deficiencies and excessive levels of glucose fatty acids, increases the risk for congenital heart disease (CHD) in offspring. However, association between amino‐acid CHD is unclear. Here, it shown that increased leucine plasma during first trimester are associated with elevated High increase embryonic lysine‐leucylation (K‐Leu), which catalyzed by leucyl‐tRNA synthetase (LARS). LARS preferentially binds to catalyzes K‐Leu modification...
Abstract Background Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite significant progress, existing PI3K inhibitors encounter various challenges such suboptimal bioavailability, potential off-target effects, restricted therapeutic indices, cancer-acquired resistance. Hence, novel that overcome some these needed. Here, we describe the characterization KTC1101, a pan-PI3K inhibitor...
TEN1 is a component of the mammalian CTC1-STN1-TEN1 complex. CTC1 and/or STN1 functions in telomere duplex replication, C-strand fill-in, and genome-wide restart replication following fork stalling. Here we examine role human ask whether it also as specialized factor. depletion causes an increase multitelomere fluorescent situ hybridization (FISH) signals similar to that observed after or depletion. However, results increased loss. This loss not accompanied by deprotection, recombination,...
Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants, has a variety of functions including anti-aging, anti-cancer anti-inflammatory activities. In the current study, we investigated beneficial effects resveratrol on vitro porcine oocyte maturation under heat stress (HS). The effect resveratrol, melatonin their combination alleviating HS was compared according to rate oocytes development competence embryos after parthenogenetic activation (PA)....
Neuroinflammation plays a key role in early brain injury (EBI) of subarachnoid hemorrhage (SAH), and NLRP3 inflammasome an important the development neuroinflammation after SAH, but mechanism activation SAH is still unclear. TRPV1 non-selective calcium channel that involved pathology neuroinflammation, its has not been revealed. Our study showed was significantly upregulated predominantly expressed microglia/macrophages. Antagonism effective ameliorating neurological impairment, edema,...
Mammalian CST (CTC1-STN1-TEN1) is a telomere-associated complex that functions in telomere duplex replication and fill-in synthesis of the telomeric C-strand following telomerase action. also facilitates genome-wide recovery after HU-induced fork stalling by increasing origin firing. CTC1 STN1 were originally isolated as DNA polymerase α stimulatory factor. Here we explore how abundance affects from drugs cause different types damage stress. We show HU aphidicolin induced stress increased...
Environmentally persistent organic pollutant (POP) is the general term for refractory compounds that show long-range atmospheric transport, environmental persistence, and bioaccumulation. It has been reported accumulation of POPs could lead to cellular DNA damage adverse effects on metabolic health. To better understand mechanism health risks associated with POPs, we conducted an evidence-based cohort investigation (n = 5,955) at Jinghai e-waste disposal center in China from 2009 2016, where...
Abstract Precise prevalence of atrial fibrillation (AF) and the associated risk factors in southern China are rarely reported. This large population-based follow-up study, Guangzhou Heart Study, was conducted from 2015 to 2017 fill up this gap. Permanent residents aged 35 years above city were enrolled demographic participants collected by a structured questionnaire. Examinations physical, electrocardiographic biochemical indicators performed following standard operation procedure designed...
Abstract The transcription factor MYC is deregulated in almost all human cancers, especially aggressive lymphomas, through chromosomal translocation, amplification, and hyperactivation. Here, we report that high expression of tribbles homologue 3 (TRIB3) positively correlates with elevated lymphoma specimens; TRIB3 deletion attenuates the initiation progression MYC-driven by reducing expression. Mechanistically, interacts to suppress E3 ubiquitin ligase UBE3B-mediated ubiquitination...