A5018557232- Endometrial and Cervical Cancer Treatments
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Cervical Cancer and HPV Research
- DNA Repair Mechanisms
- Catalytic C–H Functionalization Methods
- Ovarian cancer diagnosis and treatment
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Telomeres, Telomerase, and Senescence
- RNA Interference and Gene Delivery
- Legume Nitrogen Fixing Symbiosis
- Nematode management and characterization studies
- Mesenchymal stem cell research
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Gynecological conditions and treatments
- Toxin Mechanisms and Immunotoxins
- Plant and Fungal Interactions Research
- Cyclopropane Reaction Mechanisms
- RNA modifications and cancer
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- Bladder and Urothelial Cancer Treatments
- Gestational Trophoblastic Disease Studies
Tianjin Medical University
2018-2023
Jiangsu Academy of Agricultural Sciences
2021
Institute of Plant Protection
2021
Huaqiao University
2018-2020
East China University of Science and Technology
2017-2019
Xinjiang Medical University
2007-2012
Tumor Hospital of Xinjiang Medical University
2007-2011
Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres genome-wide. We previously showed binds disrupts G-quadruplex (G4) in vitro, suggesting may prevent vivo blocks to by resolving G4 structures. Here, we demonstrate unfolds similar efficiency RPA. In cells, recruited telomeric non-telomeric chromatin upon stabilization, even when ATR/ATM pathways were inhibited. STN1 depletion increases...
The generation of 2,3-dihydro-benzo[c][1,2]diazepine derivatives via rhodium(III)-catalyzed [4+3] annulation pyrazolidinones and propargylic acetates is disclosed. reaction proceeds smoothly under relatively mild conditions from as novel C3 synthons. A range dinitrogen-fused heterocyclic compounds are readily accessed by this approach.
An efficient protocol to synthesize substituted benzo[4,5]imidazo[1,2- c]quinazolines starting from N-LG-2-phenylbenzoimidazole and dioxazolones catalyzed by Rh(III) or Ir(III) has been developed. Various could be easily provided in up 99% yield. A large range of substrates functional groups are compatible for this transformation. This method features low catalyst loading, acid-free conditions, solvent consumption.
The C═N double bond of 2H-imidazole has been employed as a C-electrophile for the ruthenium(II)-catalyzed [3 + 2] spiroannulation reaction 4-phenyl-2H-imidazoles and 2-alkynoates to synthesize spiroimidazole-4,1′-indenes. This strategy features high regioselectivity, broad functional group tolerance, use ruthenium catalyst, providing new method spirocycles with potential applications in pharmaceuticals.
PRIMPOL (primase-polymerase) is a recently discovered DNA primase-polymerase involved in damage tolerance and replication stress response eukaryotic cells. However, the detailed mechanism of to remains elusive. Here, we demonstrate that replication-related factors, including protein A (RPA), regulate accumulation subnuclear foci induced by inhibitors. Moreover, works at G-quadruplexes (G4s) human cells resolve G4s. The formation persists throughout cell cycle. We further competes with RAD51...
A series of 4-thiazolidinone derivatives were synthesized and evaluated as novel human dihydroorotate dehydrogenase (hDHODH) inhibitors. Compounds 26 31 displayed IC50 values 1.75 1.12 μM, respectively. The structure-activity relationship was summarized. Further binding mode analysis revealed that compound could form a hydrogen bond with Tyr38 water-mediated Ala55, which may be necessary for maintaining the bioactivities compounds in this series. structural optimization para- or...
Four series of novel 1,3-thiazin(thiazol)-4-one derivatives were synthesized by Suzuki coupling. Preliminary bioassays showed that most the compounds exhibited good inhibitory activity in vivo against root-knot nematodes, Meloidogyne spp. at 20 mg L −1 . Among tested compounds, we found two displayed 46.4% and 41.4% even 1 , respectively.
Abstract Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres genome-wide. We previously showed binds disrupts G-quadruplex (G4) in vitro , suggesting may prevent vivo blocks to by resolving G4 structures. Here, we demonstrate unfolds similar efficiency RPA. In cells, recruited telomeric non-telomeric chromatin upon stabilization. STN1 depletion increases accumulation slows bulk genomic...