A5100343440- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- T-cell and Retrovirus Studies
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Cancer-related gene regulation
- Hedgehog Signaling Pathway Studies
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Medical Imaging and Pathology Studies
- RNA regulation and disease
- Immune Response and Inflammation
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Nanchang University
2024
Peking Union Medical College Hospital
2024
University of Science and Technology of China
2024
Chinese PLA General Hospital
2024
Guangzhou Center for Disease Control and Prevention
2023
Antibiotic (Bulgaria)
2022
Xuzhou Medical College
2022
Shaanxi Normal University
2021
Central South University
2020
Abstract The existence of breast cancer stem cells (BCSCs) is a major reason underlying metastasis and recurrence after chemotherapy radiotherapy. Targeting BCSCs may ameliorate relapse therapy resistance. Here we report that expression the pseudokinase Tribble 3 (TRIB3) positively associates with stemness progression. Elevated TRIB3 supports by interacting AKT to interfere FOXO1-AKT interaction suppress FOXO1 phosphorylation, ubiquitination, degradation E3 ligases SKP2 NEDD4L. accumulated...
High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable prognosis and satisfactory response to immunotherapy; however, the vast majority of patients with CRC do not benefit from immunotherapy due poor infiltration. Therefore, better understanding mechanisms for exclusion tumors is needed. Tribbles homolog 3 (TRIB3) has been implicated as an oncoprotein, but its role regulating antitumor immune responses defined. Here, we demonstrated that TRIB3 inhibits various...
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis. However, how aberrant autophagy promotes fibrosis far from understood. Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for stress protein TRIB3 (tribbles pseudokinase 3)-mediated dysfunction. Human fibrotic liver tissues were obtained patients with cirrhosis who underwent an open surgical repair process. The functional implications evaluated mouse models induced by bile duct...
Abstract High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy resistance across cancer types, including non-small cell lung (NSCLC). EGFR tyrosine kinase inhibitors (TKIs) are first-line for NSCLC. However, patients eventually deteriorate after inevitable acquisition TKI-resistant mutations, highlighting the need therapeutics with alternative mechanisms action. Here, we report that elevated tribbles pseudokinase 3...
CD8 + T cell activation leads to the rapid proliferation and differentiation of effector cells (T effs ), which mediate antitumor immunity. Although aerobic glycolysis is preferentially activated in , mechanisms that regulate glucose uptake low-glucose acidic tumor microenvironment (TME) remain poorly understood. Here, we report abundance transporter GLUT10 increased during Specifically, deficiency inhibited uptake, glycolysis, efficiency tumor-infiltrating cells. Supplementation with alone...
The MEK-ERK signaling pathway and autophagy play an important role for enterovirus71(EV71) replication. Inhibition of is shown to impair EV71 Berberine (BBR), isoquinoline alkaloid isolated from Berberis vulgaris L., has been reported have ability regulate this autophagy. Herein, we want determine whether berberine can inhibit infection by downregulating the MEK/ERK autophagy.The antiviral effect was determined cytopathic (CPE) assay, western blotting assay qRT-PCR assay. mechanism BBR...
Abstract Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe synthetic retinoid, namely WYC-209, which inhibits proliferation murine melanoma tumor-repopulating cells (TRCs), known to resist conventional drug treatment, with an IC 50 0.19 μM in dose-dependent manner. WYC-209 also TRCs human melanoma, lung cancer, ovarian breast culture. Interestingly, treated fail resume even after washout....
Abstract In this study, the effects of Baicalin on hyperglycemia-induced cardiovascular malformation during embryo development were investigated. Using early chick embryos, an optimal concentration (6 μM) was identified which could prevent embryos. Hyperglycemia-enhanced cell apoptosis reduced in embryos and HUVECs presence Baicalin. Hyperglycemia-induced excessive ROS production inhibited when administered. Analyses SOD, GSH-Px, MQAE GABAA suggested plays antioxidant role possibly through...
Abstract Dysregulated hematopoietic niches remodeled by leukemia cells lead to imbalances in immunological mediators that support leukemogenesis and drug resistance. Targeting immune may ameliorate disease progression tyrosine kinase inhibitor (TKI) resistance Philadelphia chromosome-positive B-ALL (Ph + B-ALL). Here, we show T helper type 17 (Th17) IL-17A expression are distinctively elevated Ph patients. promotes the of B-ALL. Mechanistically, activates BCR-ABL, IL6/JAK/STAT3, NF-kB...
Enterovirus A71 (EV-A71) is the main pathogen causing hand, foot and mouth disease (HFMD) in children occasionally associated with neurological diseases such as aseptic meningitis, brainstem encephalitis (BE) acute flaccid paralysis. We report here that cellular pseudokinase tribbles 3 (TRIB3) facilitates infection of EV-A71 via dual mechanisms. In one TRIB3 maintains metabolic stability scavenger receptor class B member 2 (SCARB2),
Cell-penetrating peptides provide a unique platform to create new generation of cancer therapeutics with enhanced efficacy and diminished toxicity. In our study, expression toll-like receptor 2 (TLR2) was observed in acute myeloid leukemia (AML) cells. Screening phage display peptide library using Biopanning Rapid Analysis Selective Interactive Ligands (BRASIL) identified TLR2-binding motif, Pep2. We show that the motif targeted penetrated into cells TLR2-dependent manner. Moreover,...
Background Heart failure (HF) is one of the most significant causes morbidity and mortality for cardiovascular risk population. We found previously that extracellular HSP70 (heat shock protein) an important trigger in cardiac hypertrophy fibrosis, which are associated with development heart dysfunction. However, potential role response to HF whether it could be a target therapy remain unknown. Methods Results An mouse model was generated by single IP injection doxorubicin at dose 15 mg/kg....
Acute myeloid leukemia (AML) featuring retinoic acid receptor-gamma (RARG) rearrangements exhibits morphological features resembling those of acute promyelocytic but is associated with drug resistance and poor clinical outcomes. However, the mechanisms underlying role RARG fusions in leukemogenesis remain elusive. Here, we show that disrupt differentiation promote proliferation self-renewal hematopoietic stem progenitor cells (HSPCs) by upregulating BCL2 ATF3. overexpression leads to...
Colorectal cancer (CRC) is the third most common in China. The incidence of CRC has been increasing recent years. aim this study was to explore trends and age distribution by subsite Guangzhou between 2000 2011. A total 22,432 incident cases 2011 from Cancer Registry were identified. Crude age-standardized rates (ASRs), using Segi's world standard population, calculated for subsites. trend analyzed annual percentage change (APC) JoinPoint software. crude increased significantly 23.4/105...
CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC (hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we perform a gene CRISPR/Cas9 knockout library screen in tumorspheres derived from cells find that deletion of SCARB2 suppresses the cancer cell-like properties cells. Knockout Scarb2 hepatocytes attenuates initiation progression both MYC-driven DEN (diethylnitrosamine)-induced mouse models. Mechanistically, binding MYC...
Most basal-like breast cancers (BLBCs) are triple-negative (TNBCs), which have the worst prognosis and distant metastasis-free survival among cancer subtypes. Now, no targeted therapies available for patients with BLBC due to lack of reliable effective molecular targets. Here, we performed tissue microarray-based immunohistochemical analysis showed that Faciogenital Dysplasia 5 (FGD5) abundance is associated poor in BLBCs. FGD5 deletion decreased proliferation, invasion, tumorsphere...
Pulmonary fibrosis (PF) is a chronic, progressive, fatal interstitial lung disease with limited available therapeutic strategies. We recently reported that the protein kinase glycogen synthase kinase-3β (GSK-3β) interacts and inactivates ubiquitin-editing enzyme A20 to suppress degradation of transcription factor CCAAT/enhancer-binding beta (C/EBPβ) in alveolar macrophages (AMs), resulting profibrotic phenotype AMs promoting development PF. Here, we showed chronic injury upregulated stress...
Pulmonary fibrosis (PF) is the pathological structure of incurable fibroproliferative lung diseases that are attributed to repeated injury-caused failure alveolar regeneration (LAR). Here, we report repetitive damage results in a progressive accumulation transcriptional repressor SLUG epithelial type II cells (AEC2s). The abnormal increased inhibits AEC2s from self-renewal and differentiation into I (AEC1s). We found elevated represses expression phosphate transporter SLC34A2 AEC2s, which...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous and aggressive disease with poor prognosis. Histone deacetylase (HDAC) inhibitors have shown inhibitory effects on PTCL. A better understanding of the therapeutic mechanism underlying HDAC could help improve treatment strategies. Herein, we found that high expression HDAC3 associated prognosis in inhibition suppressed growth immunocompetent mice but not immunodeficient mice. deletion delayed progression lymphoma, reduced burden thymus,...