A5101484822- Viral-associated cancers and disorders
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Pneumonia and Respiratory Infections
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Credit Risk and Financial Regulations
- Influenza Virus Research Studies
- Retinoids in leukemia and cellular processes
- Hemodynamic Monitoring and Therapy
- Chronic Myeloid Leukemia Treatments
- Financial Risk and Volatility Modeling
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Stochastic processes and financial applications
- Bacterial Infections and Vaccines
- Phytochemicals and Antioxidant Activities
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
Beijing Chao-Yang Hospital
2024-2025
Capital Medical University
2024-2025
China Academy of Chinese Medical Sciences
2025
Soochow University
2020-2025
Fudan University
2006
Acute myeloid leukemia (AML) featuring retinoic acid receptor-gamma (RARG) rearrangements exhibits morphological features resembling those of acute promyelocytic but is associated with drug resistance and poor clinical outcomes. However, the mechanisms underlying role RARG fusions in leukemogenesis remain elusive. Here, we show that disrupt differentiation promote proliferation self-renewal hematopoietic stem progenitor cells (HSPCs) by upregulating BCL2 ATF3. overexpression leads to...
This study aimed to describe the epidemiological trends of Mycoplasma pneumoniae (MP) infection among children with acute respiratory tract infections (ARTIs) before, during and after COVID-19 pandemic, evaluating impact non-pharmaceutical interventions (NPIs) on epidemiology MP infection. Children ARTIs admitted Children's Hospital Soochow University (SCH) from January 2010 December 2023 underwent nucleic acid PCR assay were included. Clinical data age, sex, onset time detection result...
This study aims to evaluate the impact of non-pharmaceutical interventions (NPIs) on prevalence respiratory pathogens among hospitalised children with acute infections (ARIs) in Suzhou. Children ARIs admitted Children's Hospital Soochow University between 1 September 2021 and 31 December 2022 subjected 13 pathogen multiplex PCR assays were included study. We retrospectively collected demographic details, results panel tests, discharge diagnostic information participants, described age...
Epstein-Barr virus (EBV) is a globally prevalent herpesvirus associated with multiple diseases. This study aimed to determine the characteristics of primary EBV infection disease spectrum and reactivation in children, Suzhou, China. All children admitted Children's Hospital Soochow University between May 2018 September 2020 suspected EBV-associated subjected indirect immunofluorescence assay for EBV-specific antibodies plasma EBV-DNA assays were included. Of 3567 2782 (78.0%) tested positive...
This study aimed to describe the prevalence of Epstein-Barr virus (EBV)-DNA among children in Suzhou, and explore association between plasma EBV load disease diagnosis.All admitted Children's Hospital Soochow University January 2018 September 2020 subjected EBV-DNA assay were included. The authors retrospectively collected demographic discharge diagnostic information participants, ascribed distribution characteristics with positive by age viral load.A total 38,175 patients underwent PCR...
Abstract Background Acute kidney injury (AKI) is independently related to the adverse outcome of septic shock, but it lacks effective early predictors. Renal anginal index (RAI) was used predict subsequent severe AKI (AKIs) in critically ill patients. The application RAI children with shock has not been reported. This study aims evaluate efficacy predicting AKIs within 3 days after PICU admission by comparing fluid overload (FO) and creatinine elevation. Methods Sixty-six admitted aged 1...
Clinical manifestations of Epstein-Barr virus (EBV) infection are diverse. This study aimed to explore the immune response in EBV-related diseases and correlation between cells adenosine deaminase (ADA) levels.This was conducted at Children's Hospital Soochow University. In total, 104 patients with EBV-associated respiratory tract (EBV-RTI), 32 atypical EBV infection, 54 infectious mononucleosis (IM1, normal alanine aminotransferase [ALT] levels), 50 EBV-IM2 (with elevated ALT acute (AURI,...
Adenosine deaminase (ADA) is an enzyme involved in purine metabolism with important role cellular immunity. Thus, this study investigated the association between ADA and Epstein-Barr virus (EBV)-related diseases. We retrospectively collected data from all children admitted to Children's Hospital of Soochow University, Suzhou, China, May 1, 2018, March 31, 2019, who underwent plasma EBV-DNA polymerase chain reaction, alanine aminotransferase (ALT), testing. Of 6868 children, 1877 had elevated...
H3N2 and Omicron are common pathogens of respiratory infections in children. This study aimed to explore dynamic changes lymphocyte subsets the diagnostic value CD19+ B cell children infected with influenza A Omicron. One hundred sixty-five in-patients H3N2, 175 variant, 50 age-matched healthy from Children's Hospital Soochow University were included this study. The participants underwent 13 by DNA polymerase chain reaction (PCR), sputum culture, severe acute syndrome coronavirus 2...