A5100414106- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Sepsis Diagnosis and Treatment
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Hemodynamic Monitoring and Therapy
- Polymer composites and self-healing
- Cyclopropane Reaction Mechanisms
- Renal function and acid-base balance
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Reactions
- Carbohydrate Chemistry and Synthesis
- Catalytic Alkyne Reactions
- Healthcare Decision-Making and Restraints
- Microbial Metabolism and Applications
- Ethics and Legal Issues in Pediatric Healthcare
- Phosphorus compounds and reactions
- Electrolyte and hormonal disorders
- DNA Repair Mechanisms
- Palliative Care and End-of-Life Issues
- Emergency and Acute Care Studies
- Genetics and Neurodevelopmental Disorders
Soochow University
2012-2021
Wuyi University
2021
Lanzhou University
1994-2011
Lanzhou Institute of Chemical Physics
1994
Chinese Academy of Sciences
1994
Call on triple A: Palladium-catalyzed asymmetric allylic alkylation (Pd-AAA; see scheme) has enabled a concise and efficient synthesis of hyperolactone C (−)-biyouyanagin A in only six (20 % overall yield) seven (8 steps, respectively. The enantiomers these natural products were also prepared by exploiting the same methodology.
To evaluate whether early and acquired daily fluid overload (FO), as well fluctuations in accumulation, were associated with adverse outcomes critically ill children severe sepsis.This study enrolled 202 a pediatric intensive care unit (PICU) sepsis. Early was defined ≥5% accumulation occurring the first 24 hours of PICU admission. The maximum during next 6 days patients at least 48 stay PICU-acquired overload. fluctuation calculated difference between minimum obtained 7 after admission.Of...
This work provides an unprecedented example for the exploration of cyclic topology effects on shape memory performance bulk polyurethane materials, providing a novel angle to elucidate structure–property relationship polymeric materials.
Carbonyl compounds react with organozinc reagents in the presence of diphenyl phosphite to give corresponding olefins. A variety 1,3-dienes and unsaturated esters were obtained moderate excellent yields under mild conditions.
Background: The mortality prediction scores were widely used in pediatric intensive care units. However, their performances unclear Chinese patients and there also no reports based on large sample sizes China. This study aims to evaluate the of three existing severity assessment predicting PICU identify important determinants. Methods: prospective observational cohort was carried out eight multidisciplinary, tertiary-care PICUs teaching hospitals All eligible admitted between Aug 1, 2016,...
The utility of allylsamarium bromide, both as a nucleophilic reagent and single-electron transfer reagent, in the reaction carbonyl compounds with bromide presence diethyl phosphate is reported this communication. From synthetic point view, simple one-pot method for preparation terminal olefins developed.
Through a biomimetic pathway, hyperolactone D, 4-hydroxyhyperolactone and C were synthesized from methyl acetoacetate via Weiler's dianion method, asymmetric allylic alkylation, lactonization, oxidation, cyclization. The stereochemistry of the quaternary carbon was controlled efficiently by Palladium-catalyzed alkylation. This strategy also used for synthesis B.
Abstract A divergent synthesis of skeletally distinct arboridinine and arborisidine was achieved. The central strategy inspired by the biosynthetic cyclization mode their hidden topological connection. branch point reached through a Michael Mannich cascade process. site‐selective intramolecular reaction developed to construct tetracyclic core arboridinine, while α‐amination ketone used access arborisidine. strategic Peterson olefination nucleophile delivery able set up exocyclic olefin arboridinine.
Abstract Background X-linked lymphoproliferative disease (XLP) is a rare inherited primary immunodeficiency diseases (PID). One such disease, inhibitor of apoptosis protein (XIAP) deficiency, characterized by Epstein–Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH). However, EBV-HLH with coronary artery dilation and acute renal injury (AKI) in children unusual. Case presentation We report the case young boy aged 17 months novel XIAP variant. He was initially diagnosed based on...
Abstract Background Acute kidney injury (AKI) is independently related to the adverse outcome of septic shock, but it lacks effective early predictors. Renal anginal index (RAI) was used predict subsequent severe AKI (AKIs) in critically ill patients. The application RAI children with shock has not been reported. This study aims evaluate efficacy predicting AKIs within 3 days after PICU admission by comparing fluid overload (FO) and creatinine elevation. Methods Sixty-six admitted aged 1...
Abstract Cembrene-C (1), a natural occurring cembrane hydrocarbon diterpene, was prepared from farnesyl acetate (3) via four steps in 21% overall yield by titanium-induced macrocyclization as the key step.
Abstract 6,10,14-Trimethyl-5E, 9E-pentadecadiene-2,13-dione, a natural marine C18 terpenoid isolated from the brown alga of Cystophora moniliformis, was prepared available geranylacetone via 4 steps in 35% overall yield by selective alkylation lithium enolate methyl isopropyl ketone with correspounding allylic iodide.
The first total syntheses of knerachlin A and B are described, starting from 2,4,6-trihydroxyacetophenone 2,6-dihydroxyacetophenone, respectively. key step in the synthesis is condensation ketone 5 with cinnamaldehyde.
Abstract Background Published data and practice recommendations on end-of-life care generally reflect Western frameworks; there are limited withdrawal of treatment for children in China. Methods Withdrawal the pediatric intensive unit (PICU) a regional children’s hospital eastern China from 2006 to 2017 was studied retrospectively. categorized as medical or premature withdrawal. The guardian’s self-reported reasons abandoning child’s were recorded 2011. Results incidence PICU decreased...
In this Communication, the discussion of work by Kraus research group was not precisely expressed and should be corrected to following: Wei[3d] reported that 7 its diastereomer, which were claimed isolated as by-products in their elegant synthesis racemic hyperolactone C, could converted into a lactone using heat, acid (PTSA), or base (tBuOK, NaH, KH) catalysis. However, careful analysis comparison NMR data 13 (1:1 mixture diastereomers) with both Wei indicated they identical (see Supporting...
Abstract (±)‐(1 E ,3 ,11 )‐Cembra‐1,3,11‐trien‐6‐one, an important marine cembrane ketone isolated from Eunicea calyculata , was first synthesized in 12 steps starting citronellal.
Abstract Background Cockayne syndrome (CS) is a rare autosomal recessive disorder which displays multiorgan dysfunction, especially within the nervous system including psychomotor retardation, cerebral atrophy, microcephaly, cognitive mental and seizures. Many genetic variations reported were related to this syndrome, but splicing mutations with cardiac anomalies have not been found in previous studies. Methods Herein, we described pair of brothers sisters who present essential...
In dieser Zuschrift muss die Beschreibung der Arbeiten aus Gruppe von Kraus (Seite 7995, linke Spalte, letzter Absatz) wie folgt korrigiert werden: “Kraus and Wei[3d] reported that 7 its diastereomer, which were claimed to be isolated as by-products in their elegant synthesis of racemic hyperolactone C, could not converted into a lactone using heat, acid (PTSA), or base (tBuOK, NaH, KH) catalysis. However, careful analysis comparison the NMR data 13 (1:1 mixture diastereomers) with both by...
This is a case report of girl with glutaric acidemia type I (GA-I) who experienced rhabdomyolysis and acute kidney injury (AKI). Her first metabolic crisis occurred at the age 5 months, which mainly manifested as irritable crying, poor appetite, hyperlactatemia. Mutation analysis showed 2 pathogenic mutations in glutaryl-CoA dehydrogenase (GCDH) gene, were c.383G>A (p.R128Q) c.873delC (p.N291Kfs*41), latter novel frameshift mutation GA-I. She had febrile illness 12 followed by AKI...
Abstract A divergent synthesis of skeletally distinct arboridinine and arborisidine was achieved. The central strategy inspired by the biosynthetic cyclization mode their hidden topological connection. branch point reached through a Michael Mannich cascade process. site‐selective intramolecular reaction developed to construct tetracyclic core arboridinine, while α‐amination ketone used access arborisidine. strategic Peterson olefination nucleophile delivery able set up exocyclic olefin arboridinine.