A5101924956- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Structural Load-Bearing Analysis
- Structural Behavior of Reinforced Concrete
- Systemic Lupus Erythematosus Research
- Hemodynamic Monitoring and Therapy
- Nephrotoxicity and Medicinal Plants
- Renal function and acid-base balance
- Dialysis and Renal Disease Management
- Neonatal Respiratory Health Research
- Structural Engineering and Vibration Analysis
- Osteomyelitis and Bone Disorders Research
- Pancreatitis Pathology and Treatment
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Methemoglobinemia and Tumor Lysis Syndrome
- Complement system in diseases
- Fire effects on concrete materials
- Atherosclerosis and Cardiovascular Diseases
- Higher Education and Teaching Methods
- Web and Library Services
- Adenosine and Purinergic Signaling
Soochow University
2016-2025
Second Affiliated Hospital of Nanchang University
2020-2025
Nanchang University
2020-2025
Center for Disease Control
2025
University Town of Shenzhen
2021-2024
Harbin Institute of Technology
2021-2024
Shanxi Medical University
2023
Gansu University of Traditional Chinese Medicine
2014-2023
Shenzhen University
2021-2022
Children's Hospital of Fudan University
2022
Acute kidney injury (AKI) is a common and serious organ dysfunction in critically ill children. Early identification prediction of AKI are great significance. However, current criteria insufficiently sensitive specific, heterogeneity limits the clinical value biomarkers. This study aimed to establish validate an explainable model based on machine learning (ML) approach for AKI, assess its prognostic implications children admitted pediatric intensive care unit (PICU).
Abdominal aortic calcification (AAC) is recognized as a strong predictor of cardiovascular disease (CVD) events. This study aimed to evaluate the association between weight-adjusted-waist index (WWI) and AAC in United States adults aged ≥ 40 years.Data were derived from 2013-2014 National Health Nutrition Examination Survey (NHANES). WWI was calculated waist circumference divided by square root weight. scores quantified Kauppila scoring system, severe defined an score 6. Weighted...
To evaluate whether early and acquired daily fluid overload (FO), as well fluctuations in accumulation, were associated with adverse outcomes critically ill children severe sepsis.This study enrolled 202 a pediatric intensive care unit (PICU) sepsis. Early was defined ≥5% accumulation occurring the first 24 hours of PICU admission. The maximum during next 6 days patients at least 48 stay PICU-acquired overload. fluctuation calculated difference between minimum obtained 7 after admission.Of...
The triglyceride glucose (TyG) index, a metric for estimating insulin resistance (IR), is linked with cardiovascular disease (CVD) morbidity and mortality among the population regardless of diabetic status. However, IR prevalence association between TyG index heart failure (HF) in Americans unclear.The Nation Health Nutrition Examination Survey (NHANES) (2009-2018) dataset was used. defined by homeostatic model assessment (HOMA-IR) > 2.0 1.5. calculated as Ln [fasting triglycerides (mg/dL) ×...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease, also considered a metabolic syndrome, and associated with poor prognosis. eGDR (estimated glucose disposal rate) new biomarker to assessment insulin resistance (IR). The association between MASLD fibrosis currently unclear. aim of this cross-sectional study appraise fibrosis. This have enrolled 3,100 participants from 2017–2018 National Health Nutrition Examination Surveys (NHANES). Binary...
Urinary interleukin-18 and cystatin-C are suggested to be biomarkers for predicting acute kidney injury (AKI). The aims of this study examine whether the urinary concentrations vary with gestational age other factors in non-AKI control neonates, determine can predict AKI development non-septic critically ill independently potential confounders. We enrolled 62 neonates. Urine was collected every 48–72 h during first 10 days life. concentration cystatin-C, but not interleukin-18, decreased...
Objective To observe the efficacy and safety of telitacicept in refractory childhood-onset systemic lupus erythematosus (cSLE). Methods A self-controlled before–after trial. Children with active SLE, aged 5–18 years, who cannot tolerate side effects glucocorticoid, were enrolled our study. Patients received subcutaneous injection weekly based on standard treatment. SLE responder index-4 (SRI-4) was assessed before first administration at least 4 weeks after administration. Results Among 15...
Abstract Objective The aim of this study was to evaluate demographic, clinical, laboratory, imaging, histopathology characteristics, and treatment responses children with Chronic nonbacterial osteomyelitis (CNO). Methods Retrospective multi-center case series pediatric patients diagnosed CNO treated at five tertiary centers in south China. Results Totally there were 18 as between 2014 2020. median age onset 9.2 years (range 3.7–13.1) 55.6% female. Median delay diagnosis 10.9 months...
Research on acute kidney injury (AKI) has focused identifying early biomarkers. However, whether AKI could be diagnosed in the absence of classic signs clinical and condition subclinical AKI, identified by damage or functional biomarkers oliguria increased serum creatinine (sCr) levels, is clinically significant remains to elucidated critically ill children. The aims study were investigate associations between urinary cystatin C (uCysC) levels mortality determine uCysC-positive associated...
Diabetic hearts are vulnerable to myocardial ischemia/reperfusion injury (IRI), but insensitive sevoflurane postconditioning (SPC), activating peroxiredoxins that confer cardioprotection. Previous studies have demonstrated hydrogen sulfide (H2 S) can suppress oxidative stress of diabetic rats through increasing the expression silent information regulator factor 2-related enzyme 1 (SIRT1), whether cardioprotection by SPC be restored afterward remains unclear. rat was subjected IRI (30 min...
Importance Both tacrolimus (TAC) and mycophenolate mofetil (MMF) are recommended for children with frequently relapsing nephrotic syndrome (FRNS) or steroid-dependent (SDNS). However, their comparative effectiveness safety have not been evaluated through randomized clinical trials. Objective To compare the of TAC MMF in FRNS SDNS. Design, Setting, Participants In this multicenter, open-label trial conducted at 12 pediatric nephrology centers across China, 270 aged 2 to 18 years SDNS were...
A randomized, double-blind, controlled phase 3 trial was conducted during a COVID-19 outbreak after the initial, stringent zero-Covid policy relaxed in three provinces. Eligible adults aged ≥18 years who had received doses of inactivated vaccines 6 months earlier were randomly assigned 1:1 ratio to receive either one intramuscular injection RQ3013 or ZF2001 vaccine. The primary end point protection against PCR-confirmed symptomatic SARS-CoV-2 infection with onset at least 7 days booster....
Bronchopulmonary dysplasia (BPD) is the most common serious pulmonary morbidity in premature infants. The score for neonatal acute physiology (SNAP) a physiologic severity index intensive care and correlates well with mortality clinical outcomes. prognostic value of SNAP BPD preterm infants remains to be clarified. aim study was determine whether can predict development or death, investigate contribution predictive accuracy other potential perinatal risk factors adverse outcome critically...
Substantial interstudy heterogeneity exists in defining acute kidney injury (AKI) and baseline serum creatinine (SCr). This study assessed AKI incidence its association with pediatric intensive care unit (PICU) mortality under different SCr definitions to determine the preferable approach for diagnosing AKI.In this multicenter prospective observational cohort study, was defined staged according Kidney Disease: Improving Global Outcome (KDIGO), modified KDIGO, reference change value optimized...
The mechanical performance of precast RC structures relies on the connections, especially connections steel bars, between members. Grouted sleeve splices and grouted spiral-confined overlap are widely used in engineering practice China. Both these two connection require on-site grouting. process is concealed invisible, leading to difficult inspection. unseen defects cause a challenge for detection repair, which may impair reliability members’ behavior. This paper presents an member assembly...
To improve the concrete confinement and mechanical properties of concrete-filled steel tube (CFST) columns, a new configuration steel-tube-confined (T-CFST) columns has recently been developed, in which an outer is employed externally, additional does not sustain axial load directly. This preliminary experimental study revealed that, due to effective by tube, T-CFST column achieves higher compressive strength more ductile deformation compared CFST same ratio. In this study, two finite...
The aims of this study are to evaluate the relationship between early blood glucose concentrations and mortality define a 'safe range' during first 24 h after pediatric intensive care unit (PICU) admission with lowest risk mortality. We further determine whether associations exist PICU hyperglycemia hypoglycemia occurring within admission, even adjusting for illness severity assessed by III (PRISM III) score.This retrospective cohort included patients admitted July 2008 June 2011 in tertiary...