A5003446542- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Helicobacter pylori-related gastroenterology studies
- Intermetallics and Advanced Alloy Properties
- Titanium Alloys Microstructure and Properties
- Chemical Synthesis and Analysis
- Acute Myeloid Leukemia Research
- MXene and MAX Phase Materials
- Gastrointestinal Tumor Research and Treatment
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- HIV Research and Treatment
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Microbial metabolism and enzyme function
- Click Chemistry and Applications
- Ferroptosis and cancer prognosis
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bioinformatics and Genomic Networks
Hefei University of Technology
2024-2025
Beijing Tian Tan Hospital
2023-2024
Capital Medical University
2015-2024
Qilu Hospital of Shandong University
2014-2024
Shanxi Agricultural University
2024
Northwest A&F University
2024
Georgia State University
2019-2024
WuXi AppTec (China)
2021-2024
China-US (Henan) Hormel Cancer Institute
2023
Zhengzhou University
2023
Oncolytic virotherapy is a growing treatment modality that uses replicating viruses as selective antineoplastic agents. Safety and efficacy considerations dictate an ideal oncolytic agent would discriminate between normal cancer cells on the basis of common genetic abnormalities in human cancers. Here, we identify naturally occurring alphavirus (M1) novel killer targeting zinc-finger antiviral protein (ZAP)-deficient cells. In vitro, vivo, ex vivo studies showed potent high tumor tropism M1....
Abstract Irritable bowel syndrome (IBS) is a common disorder in gastrointestinal system and impairs the quality of life patients. Clostridium butyricum ( CB ) probiotics that has been used several diseases. The efficacy treating IBS still unknown. This prospective, multi-centre, randomized, double-blind, placebo-controlled trial aimed to assess safety diarrhea-predominant (IBS-D) analyze fecal microbiota after treatment. Two hundred patients with IBS-D were recruited given or placebo for 4...
Abstract High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy resistance across cancer types, including non-small cell lung (NSCLC). EGFR tyrosine kinase inhibitors (TKIs) are first-line for NSCLC. However, patients eventually deteriorate after inevitable acquisition TKI-resistant mutations, highlighting the need therapeutics with alternative mechanisms action. Here, we report that elevated tribbles pseudokinase 3...
Abstract Stapling of peptides by intramolecular crosslinking two neighboring amino acid side chains offers an important tool to modulate the structure and properties peptides. In comparison stapling artificially engineered peptide substrates, methods for native are more desirable easier accessibility genetic encodability. However, existing strategy selectivity control in is relatively limited: site anchoring often dominated Cys, means achieving position among same type residues at different...
Cluster of differentiation 36 (CD36) is highly expressed in the liver patients with metabolic dysfunction-associated fatty disease (MAFLD) or steatohepatitis (MASH). However, precise role CD36 MAFLD/MASH controversial. In current study, we aimed to uncover early stage induced by high-fat diet (HFD) and methionine/choline-deficient (MCD) diet. CD36-/- mice littermate control were fed a normal food (NCD); HFD MCD for 6 weeks. We determined that deficiency attenuated HFD-induced hepatic...
Abstract Background To investigate the effects of twice daily short‐message‐based re‐education (SMRE) before taking medicine for Helicobacter pylori ( H ) eradication. Materials and Methods Treatment‐naive patients with infection were prescribed 14‐day quadruple regimen consisting lansoprazole 30 mg, colloidal bismuth pectin 200 amoxicillin 1000 clarithromycin 500 mg daily. Patients randomly allocated to SMRE group or control group. in received oral written instructions at outpatient clinic....
<b><i>Background:</i></b> Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease without beneficial therapy, except for transplantation. A high oral dose of N-acetylcysteine (NAC) added to prednisone azathioprine has been found improve function in IPF patients, though the mechanism action remains poorly understood. <b><i>Objective:</i></b> Based on our previous findings showing elevation glutathione (GSH) content associated...
Abstract T-LAK-originated protein kinase (TOPK), a dual specificity serine/threonine kinase, is up-regulated and related to poor prognosis in many types of cancers. Y-box binding 1 (YB1) DNA/RNA serves important roles multiple cellular processes. Here, we reported that TOPK YB1 were both highly expressed esophageal cancer (EC) correlated with prognosis. knockout effectively suppressed EC cell proliferation these effects reversible by rescuing expression. Notably, phosphorylated at Thr 89...
Both melatonin and hydrogen sulfide (H2S) mitigate chromium (Cr) toxicity in plants, but the specific interaction between H2S Cr detoxification remains unclear. In this study, was elucidated by measuring cell wall polysaccharide metabolism antioxidant enzyme activity maize. The findings revealed that exposure to stress (100 μM K2Cr2O7) resulted upregulation of L-/D-cysteine desulfhydrase (LCD/DCD) gene expression, leading a 77.8% 27.3% increase endogenous levels maize leaves roots,...
Abstract In robotic-assisted surgery (RAS), traditional surgical instruments without sensing capability cannot perceive accurate operational forces during the task, and such drawbacks can be largely intensified when sophisticated tasks involving flexible slender arms with small end-effectors, as in gastrointestinal endoscopic (GES). this study, we propose a microelectromechanical system (MEMS) piezoresistive 3-axial tactile sensor for GES forceps, which intuitively provide surgeons online...
Gliomas are one of the most common types malignant tumors worldwide, however, an effective therapeutic strategy not yet been fully determined. The present study aimed to investigate anti-glioma activity and underlying mechanisms pregnenolone, which originates from cholesterol is metabolized into important steroid hormones in body. results demonstrated that 100 μM pregnenolone induced a significant loss cell viability various glioma lines. In U-87 MG, LN-18 C6 lines, resulted apoptosis, was...
Glioblastoma (GBM), the most common primary brain tumor, is aggressive malignancy in humans. Its rapid proliferation a major obstacle to successful treatment. Patients with GBM often suffer from psychological disturbances associated poor prognosis and physical discomfort. Diazepam one of frequently used benzodiazepines (BZs) cancer patients for its desirable psychotropic effects. The central effects BZs are mediated by activation BZ receptors. This study investigates whether diazepam has...