A5045954240- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Helicobacter pylori-related gastroenterology studies
- Bacterial biofilms and quorum sensing
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Probiotics and Fermented Foods
- Inhalation and Respiratory Drug Delivery
- Surfactants and Colloidal Systems
- Neuroscience and Neuropharmacology Research
- Advanced Chemical Sensor Technologies
- Antimicrobial Peptides and Activities
- Cancer, Lipids, and Metabolism
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Hair Growth and Disorders
- Galectins and Cancer Biology
- Cholesterol and Lipid Metabolism
- Biological and pharmacological studies of plants
Sun Yat-sen University
2016-2025
Shanghai Sixth People's Hospital
2019-2025
Shanghai Jiao Tong University
2021-2025
Inner Mongolia People's Hospital
2024
Shanghai University of Traditional Chinese Medicine
2016-2022
Fujian Medical University
2022
Shandong Provincial Hospital
2019
Sichuan University
2005-2019
Yantai University
2018-2019
Chongqing Three Gorges Central Hospital
2017
Oncolytic virotherapy is a growing treatment modality that uses replicating viruses as selective antineoplastic agents. Safety and efficacy considerations dictate an ideal oncolytic agent would discriminate between normal cancer cells on the basis of common genetic abnormalities in human cancers. Here, we identify naturally occurring alphavirus (M1) novel killer targeting zinc-finger antiviral protein (ZAP)-deficient cells. In vitro, vivo, ex vivo studies showed potent high tumor tropism M1....
Dendrobium is a traditional Chinese herb with anti-diabetic effects and has diverse bibenzyls as well phenanthrenes. Little known about polyphenols activities, so, rich-polyphenols extract of D. loddigesii (DJP) was used for treatment diabetic db/db mice; the serum biochemical index tissue appearance were evaluated. In order to gain an insight into mechanism, oxidative stress index, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) gut microbiota modulation determined by ELISA,...
Protein and peptide drugs orally suffer from extremely low bioavailability principally for the complicated gastrointestinal environment along with difficulty of passing through mucus layer underlying epithelium. In our work, we fabricated mesoporous silica nanoparticles modification groups (MSN-NH2@COOH/CPP5) that effectively penetrated passed intestinal epithelium by mimicking virus surface. Naked were prepared inner pores 6 nm diameter to allow efficient insulin loading coated cationic...
Long chain and short curaremimetic toxins from snakes possess 66–74 residues with five disulfide bonds 60–62 four bonds, respectively. Despite their structural differences all of these bind high affinity to the peripheral nicotinic acetylcholine receptors (AChR). Binding experiments have now revealed that long only, like neuronal κ-bungarotoxin, a for chimeric form α7 receptor, <i>K</i> <sub>d</sub> values ranging about 1 12 nm. In contrast, other receptor low affinity, with<i>K</i> between...
The oral absorption of exenatide, a drug for type 2 diabetes treatment, can be improved by using nanoparticles (NPs) its delivery. To improve the mucus penetration and intestinal we designed block copolymer, CSKSSDYQC-dextran-poly(lactic-co-glycolic acid) (CSK-DEX-PLGA), used it preparation exenatide-loaded NPs. functionalized NPs composed CSK-DEX-PLGA were able to target epithelial cells reduce mucus-blocking effect intestine. Moreover, CSK modification DEX-PLGA was found significantly...
The aims of this study were to determine the effect curcumin on osteosarcoma (OS) cells due inactivation p-JAK2/p-STAT3 pathway and evaluate prognostic value in OS.We exposed a human OS cell line (MG-63) different concentrations curcumin. Then, we characterized effects MG-63 using assays (cell viability, colony formation, cycle, wound healing, invasion), flow cytometry, Western blot, immunohistochemical analyses, tumor xenograft.The half-maximal inhibitory for at 24 hours was 27.6 µM. number...
Oncolytic viral therapy is an attractive novel strategy for cancer therapy. As a natural alphavirus, oncolytic virus M1 able to infect and kill various zinc finger antiviral protein (ZAP)-deficient tumor cells selectively, while leaving normal undamaged. However, can trigger the production of neutralizing antibodies that dramatically weaken its antitumor effect. In order attenuate immunogenicity therapeutic virus, we encapsulated it into liposomes (referred as M-LPO) using thin-film...
A novel berberine-mediated mitochondria-targeting nano-platform was constructed to inhibit tumor growth and bypass the multi-drug resistance problem by targeting doxorubicin mitochondria of cells.
Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death the CNS in various disorders, including cerebral and spinal cord ischemia. However, intrinsic physiological mechanisms modulation these are essentially unknown. Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite cholesterol, an endogenous neuroprotectant protects against injury both vitro vivo via negative NMDA receptors. Treatment cultured neurons with triol...
Pseudomonas aeruginosa (P. aeruginosa) infections are increasingly challenging due to their propensity form biofilms and low outer membrane permeability, especially in chronically infected patients with thick mucus. P. exhibits multiple drug resistance mechanisms, making it one of the most significant global public health threats. In this study, we found that moxifloxacin (MXC) antibacterial peptides (ε-poly-l-lysine, ε-PLL) exhibited a synergistic effect against multidrug-resistant (MDR-P....