A5112354432- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Antibiotic Resistance in Bacteria
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Antimicrobial Peptides and Activities
- Hydrogels: synthesis, properties, applications
- Cystic Fibrosis Research Advances
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Nanoparticle-Based Drug Delivery
- Probiotics and Fermented Foods
- Microfluidic and Capillary Electrophoresis Applications
- Drug Solubulity and Delivery Systems
- Pneumonia and Respiratory Infections
- Lipid Membrane Structure and Behavior
- Supercapacitor Materials and Fabrication
- Antimicrobial agents and applications
- Dermatologic Treatments and Research
- Graphene research and applications
- Curcumin's Biomedical Applications
- Synthesis of β-Lactam Compounds
- Nuclear Receptors and Signaling
- Retinopathy of Prematurity Studies
- Polymer Surface Interaction Studies
Sun Yat-sen University
2021-2025
Shenyang Pharmaceutical University
2014-2024
Kingmed Diagnostics
2024
Huanggang Normal University
2024
Purdue University West Lafayette
2018-2022
Bridge University
2021
Hainan University
2021
Yunnan University
2021
Abstract The transient precorneal retention time and low penetration capacity into intraocular tissues are the key obstacles that hinder ophthalmic drug delivery of many therapeutic compounds, especially for drugs with poor solubility permeability. To break stalemate, N-acetyl-L-cysteine functionalized chitosan copolymer (CS-NAC), which exhibit marked bioadhesion permeation enhancing effect, was synthesized. curcumin encapsulated NLC (CUR-NLC) produced optimized followed by surface...
Protein and peptide drugs orally suffer from extremely low bioavailability principally for the complicated gastrointestinal environment along with difficulty of passing through mucus layer underlying epithelium. In our work, we fabricated mesoporous silica nanoparticles modification groups (MSN-NH2@COOH/CPP5) that effectively penetrated passed intestinal epithelium by mimicking virus surface. Naked were prepared inner pores 6 nm diameter to allow efficient insulin loading coated cationic...
We developed a hybrid nanostructured lipid carrier/dual pH- and thermo-sensitive hydrogel (NLC-Gel) for ocular delivery of quercetin (QN). The consisted carboxymethyl chitosan poloxamer 407 (P407) was cross-linked using naturally occurring cross-linker genipin (GP), while the glutaraldehyde used as control. NLC loaded with quercetin/hydrogel by drug system (QN-NLC-Gel-GP) exhibited better cytocompatibility lower irritation than its counterpart. levels cellular uptake in NLC-Gel groups were...
Abstract: This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) produced using melt-emulsification technique followed by surface absorption EDU 100. 100 increased zeta potential from −7.46 mV +13.60 mV, uniformly forming spherical coating outside surface, as shown transmission electron microscopy images. on effectively improved stability inhibiting particle size...
Schematic illustration of the novel formulation (nanostructured lipid carriers-based hydrogels) instills into surface eyes and results cytotoxicity cell uptake for optimal formulation.
Novel polyelectrolyte complex nanoparticles (AAP/LCS NPs) were prepared in this study and these produced by mixing negatively charged auricularia auricular polysaccharide (AAP) with positively low molecular weight chitosan (LCS) an aqueous medium. The AAP was extracted purified from auricular, then characterized micrOTOF-Q mass spectrometry, UV/Vis spectrophotometry, moisture analyzer SEM. yield, moisture, total sugar content of the 4.5%, 6.2% 90.12% (w/w), respectively. sample water-soluble...
Inhaled antibiotics such as colistin and ciprofloxacin are increasingly used to treat bacterial lung infections in cystic fibrosis patients. In this study, we established validated a new HPLC-MS/MS method that could simultaneously detect drug concentrations of ciprofloxacin, ivacaftor rat plasma, human epithelial cell lysate, culture medium, transport media. An aliquot 200 μL drug-containing plasma or medium was treated with 600 extraction solution (acetonitrile containing 0.1% formic acid...
The aim of this study was to prepare and evaluate ion-activated in situ gel ophthalmic drug delivery system based on κ-carrageenan (KC), using acyclovir as a model drug, hydroxypropyl methylcellulose (HPMC) the viscosity agent hydroxypropyl-β-cyclodextrin (HP-β-CD) penetration enhancer. two ternary phase diagrams exhibited effect K+ Ca2+ sol-to-gel transition, which turned out that KC more sensitive K+. optimal matrix (prepared from HPMC) optimized with vitro release test. apparent...
Background: The objective of this study was to develop a more bio-available and safe nanosuspension meloxicam (MX), which could dramatically improve inflammation targeting. Methods results: MX-loaded bovine serum albumin (BSA) nanosuspensions were prepared using acid–base neutralization in aqueous solution the characterized. results obtained showed that had narrow size distribution with mean particle 78.67±0.22 nm, polydispersity index 0.133±0.01, zeta potential -11.87±0.91 mV. MX...