A5050382136- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Neuroscience and Neuropharmacology Research
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Traditional Chinese Medicine Analysis
- Advanced Drug Delivery Systems
- Hepatitis B Virus Studies
- Dermatology and Skin Diseases
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Retinal Imaging and Analysis
- Fault Detection and Control Systems
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Neural Networks and Applications
- Acute Ischemic Stroke Management
- Surfactants and Colloidal Systems
- Flavonoids in Medical Research
- Analytical Chemistry and Chromatography
Shenyang Pharmaceutical University
2016-2025
Hubei University of Chinese Medicine
2024
Beijing Academy of Artificial Intelligence
2022-2024
Robert Bosch (Germany)
2024
Bridge University
2016
Background: COVID-19 has become one of the most serious global epidemics in 21st Century. This study aims to explore distribution research capabilities countries, institutions, and researchers, hotspots frontiers coronavirus past two decades. In it, references for funding support urgent projects international cooperation among institutions are provided. Method: Web Science core collection database was used retrieve documents related published from 2003 2020. Citespace.5.6.R2,...
To improve the bioavailability of orally administered drugs, we synthesized a pH-sensitive polymer (poly(ethylene glycol)–poly(2-methyl-2-carboxyl-propylene carbonate)–vitamin E, mPEG–PCC–VE) attempting to integrate advantages enteric coating and P-glycoprotein (P-gp) inhibition. The aliphatic polycarbonate chain was functionalized with carboxyl groups vitamin E via postpolymerization modification. Optimized by comparison central composite design, mPEG113–PCC32–VE4 exhibited low critical...
<title>Abstract</title> Background Drug combination is currently a promising solution in treating complex diseases due to its reducing toxicity and enhancing therapeutic efficacy. However, the accurate identification of drug effects remains challenging. Results In this work, we propose novel directed weighted network-based approach identify combinations. Specifically, network constructed on both drug-target inter-target interactions, together with their regulation. The biological processes...
Understanding the neural correlates of aesthetic experiences in natural environments is a central question neuroaesthetics. A previous EEG study (Kaiser, 2022) identified early and temporally sustained representations visual scene beauty. These results were obtained with long presentation durations (1,450 ms) explicit beauty judgments, rendering it unclear how time task demands shape In two experiments, we replicated this while varying task. Experiment 1 tested whether reducing stimulus from...
Human effective intestinal membrane permeability (Peff) is one of the two important indicators for drug classification according to Biopharmaceutical Classification System (BCS), and contributes greatly performance oral absorption. Here, a structure-based in silico predictive model Peff was developed successfully facilitate BCS early stage discovery, even before compound synthesized. The quantitative structure-Peff relationship 30 drugs constructed based on seven structural parameters. Then...