A5100391273- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Plant Water Relations and Carbon Dynamics
- Inhalation and Respiratory Drug Delivery
- Bamboo properties and applications
- Genomics and Phylogenetic Studies
- Antimicrobial Peptides and Activities
- Pneumocystis jirovecii pneumonia detection and treatment
- Microbial infections and disease research
- Evolution and Genetic Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Drug Solubulity and Delivery Systems
- Gut microbiota and health
- CO2 Sequestration and Geologic Interactions
- Nosocomial Infections in ICU
- Biocrusts and Microbial Ecology
- Tree-ring climate responses
- Epilepsy research and treatment
- Soil and Unsaturated Flow
- Malaria Research and Control
- Alkaloids: synthesis and pharmacology
Australian Regenerative Medicine Institute
2018-2025
Monash University
2018-2025
Discovery Institute
2024-2025
Tzu Chi University
2022-2024
University of Chinese Academy of Sciences
2023-2024
Fujian Agriculture and Forestry University
2023-2024
Northwest Institute of Eco-Environment and Resources
2023-2024
Chinese Academy of Sciences
2023-2024
National Yang Ming Chiao Tung University
2023
Genomics Research Center, Academia Sinica
2022
A modified stochastic averaging technique is employed to calculate stability boundaries for the second‐order statistical moments bridges under turbulent wind excitations. Assuming that structural motion dominated by a coupled critical mode, contributions from other more stable modes are accounted approximately in averaging. When dimension of state space combined structure‐fluid system large this mathematically approximate procedure numerically much efficient than exact used Part I. The...
Pseudomonas aeruginosa has been highlighted by the recent WHO Global Priority Pathogen List due to multidrug resistance. Without new antibiotics, polymyxins remain a last-line therapeutic option for this difficult-to-treat pathogen. The emergence of polymyxin resistance highlights growing threat our already very limited antibiotic armamentarium and urgency understand exact mechanisms activity Integration correlative metabolomics transcriptomics results in present study discovered that...
ABSTRACT Multidrug-resistant Pseudomonas aeruginosa presents a global medical challenge, and polymyxins are key last-resort therapeutic option. Unfortunately, polymyxin resistance in P. has been increasingly reported. The present study was designed to define metabolic differences between paired polymyxin-susceptible -resistant strains using untargeted metabolomics lipidomics analyses. metabolomes of wild-type strain K ([PAK] B MIC, 1 mg/liter) its pmrB mutant strains, PAK pmrB6 pmrB12...
Multidrug-resistant
Inhaled polymyxins are of considerable utility in achieving optimal exposure the respiratory tract for treatment lung infections caused by multidrug-resistant Gram-negative pathogens. Current inhaled polymyxin therapy is empirical, and often large doses used that may lead to potential pulmonary adverse effects. This study aimed investigate effect on human epithelial (A549) cells. The viability A549 cells was examined after with flow cytometry. Activation caspases 3, 8, 9, expression Fas...
Resistance to the last-line polymyxins is emerging in multidrug-resistant Klebsiella pneumoniae and phage therapy a promising alternative. However, monotherapy often rapidly causes resistance few studies have examined antibiotic-phage combinations against K. pneumoniae. Here, we investigated combination of polymyxin B with novel pK8 an mcr-1-carrying polymyxin-resistant clinical isolate Kp II-503 (polymyxin MIC, 8 mg/L). The genome was sequenced bacterial metabolomes were analysed at 4 24 h...
Gram-negative bacteria produce outer membrane vesicles (OMVs) as delivery vehicles for nefarious bacterial cargo such virulence factors, which are antibiotic resistance determinants. This study aimed to investigate the impact of polymyxin B treatment on OMV lipidome from paired polymyxin-susceptible and -resistant Klebsiella pneumoniae isolates. K. ATCC 700721 was employed a reference strain in addition two clinical strains, FADDI-KP069 BM3. Polymyxin strains resulted marked reduction...
Carbon capture and storage (CCS) technology can reduce CO2 emissions by 85 to 95% for power plants kilns with high emissions. Among CCS technologies, carbon dioxide using steel slag is a method of carbonating minerals combining oxidized metals in the slag, such as CaO, MgO, SiO2, CO2. This study assessed amount captured sequestration efficiency operating mineral carbonation plant capacity 5 tons/day treating exhaust gas from municipal waste incinerator identified characteristics products. As...
ABSTRACT MRX-8 is a new next-generation polymyxin with potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB). This study evaluated the and meropenem combination their dosing regimens CRAB in clinics. Seven strains isolated from Huashan Hospital were tested. Two of AB21-3881 AB21-3759 selected for static time-kill Hollow Fiber Infection Model (HFIM). Adaptive resistance to was assessed via population analysis profiling (PAP) at 2 mg/L MRX-8. Multilocus...
The growth dynamics of Ma bamboo (Dendrocalamus latiflorus Munro) are intricately linked to nitrogen availability, a pivotal nutrient. Escalating global deposition, primarily driven by anthropogenic factors, is reshaping nutrient fluxes and productivity within forest ecosystems. Such alterations bear significant implications for the equilibrium yields rapid-growth species such as bamboo, thereby influencing their sustainable management strategies. This investigation delves into responses...
Polymyxins are amongst the most important antibiotics in modern medicine, recent times their clinical utility has been overshadowed by nosocomial outbreaks of polymyxin resistant MDR Gram-negative 'superbugs'. An effective strategy to surmount resistance is combination therapy with FDA-approved non-antibiotic drugs. Herein we used untargeted metabolomics investigate mechanism(s) synergy between B and selective estrogen receptor modulator (SERM) tamoxifen against a polymyxin-resistant cystic...
Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies. in β-lactams have shown remarkable synergy A. Methods: Liquid chromatography-mass spectrometry-based metabolomics was conducted to investigate metabolic perturbations an baumannii clinical isolate, AB090342, response colistin (1 mg/L), sulbactam (128 and their at...
Polymyxins are used as a last-line therapy against multidrug-resistant (MDR) New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae However, polymyxin resistance can emerge with monotherapy; therefore, novel strategies urgently needed to minimize the and maintain their clinical utility. This study aimed investigate pharmacodynamics of B in combination antiretroviral drug zidovudine K. Three isolates were evaluated static time-kill studies (0 64 mg/liter) over 48 h. An vitro...
Polymyxins are used as a last-resort class of antibiotics against multidrug-resistant (MDR) Gram-negative Pseudomonas aeruginosa. As polymyxin monotherapy is associated with potential development resistance, combination therapy highly recommended. This study investigated the mechanism underlying synergistic killing B and enrofloxacin extensive drug-resistant (XDR) P. An XDR isolate aeruginosa 12196 was treated clinically relevant concentrations (2 mg/L) (1 alone or in combination. Metabolome...
Warming coupled with precipitation changes induced by climate change profoundly affect desert ecosystem functions in global drylands. Arbuscular mycorrhizal fungi (AMF) play a crucial role such ecosystems regulating energy and nutrient exchange. However, little is known about how AMF communities respond to warming reduced (W + RP). We evaluated the impacts of 0.5 °C 1.5 increase temperature 5 % 8 reductions total annual (0.5 W RP, RP) on main ecological processes structuring community...
Abstract Background Antimicrobial resistance is a serious threat to global health. Due the stagnant antibiotic discovery pipeline, bacteriophages (phages) have been proposed as an alternative therapy for treatment of infections caused by multidrug-resistant pathogens. Genomic features play important role in phage pharmacology. However, our knowledge genomics sparse, and use existing bioinformatic pipelines tools requires considerable expertise. These challenges substantially limited clinical...
Resistance to polymyxin antibiotics is increasing. Without new antibiotic classes, combination therapy often required. We systematically investigated bacterial killing with polymyxin-based combinations against multidrug-resistant (including polymyxin-resistant), carbapenemase-producing Klebsiella pneumoniae . Monotherapies and double- triple-combination therapies were compared identify the most efficacious treatment using static time-kill studies (24 h, six isolates), an in vitro...