A5100395628- Ubiquitin and proteasome pathways
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Protein Degradation and Inhibitors
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Cancer-related Molecular Pathways
- Advanced MRI Techniques and Applications
- Cell Adhesion Molecules Research
- Aquaculture Nutrition and Growth
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Connective tissue disorders research
- HIV Research and Treatment
- Radiation Dose and Imaging
- Renal and related cancers
- Physiological and biochemical adaptations
- Lipid metabolism and disorders
- Peptidase Inhibition and Analysis
- Advanced Neuroimaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Renal and Vascular Pathologies
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
Ocean University of China
2024-2025
Nanjing Agricultural University
2025
Sun Yat-sen University
2022-2025
Peking University First Hospital
2021-2024
Peking University
2021-2024
Qilu Hospital of Shandong University
2003-2024
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Xidian University
2022-2024
Ministry of Education of the People's Republic of China
2023-2024
64-MDCT Coronary Angiography: Phantom Study of Effects Vascular Attenuation on Detection StenosisXiaolu Fei1, Xiangying Du1, Qi Yang1, Yun Shen2, Pengyu Li1, Jingmin Liao2 and Kuncheng Li1Audio Available | Share
As a component of the transcriptional repression complex 1 (PRC1), ring finger protein RING1 participates in epigenetic regulation cancer. However, contributions to cancer etiology or development are unknown. In this study, we report that is critical negative regulator p53 homeostasis human hepatocellular and colorectal carcinomas. acts as an E3 ubiquitin (Ub) ligase directly interact with ubiquitinate p53, resulting its proteasome-dependent degradation. The RING domain was required for Ub...
Abstract High-intensity Magnetic Resonance-guided Focused Ultrasound (MRgFUS) is a recent, non-invasive line of treatment for medication-resistant tremor. We used MRgFUS to produce small lesions in the thalamic ventral intermediate nucleus (VIM), an important node cerebello-thalamo-cortical tremor network, 13 patients with tremor-dominant Parkinson’s disease or essential Significant alleviation target hand ensued ( t (12) = 7.21, p < 0.001, two-tailed), which was strongly associated...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder with no effective interventions for curing or modifying its progression. However, emerging research suggests that vitamin A in the diet may play a role both prevention and treatment of AD, although exact mechanisms are not fully understood. This study aims to investigate dietary modifies gut microbiota intestinal tissue transcriptome, impacting permeability release inflammatory factors, thereby influencing Aβ pathology...
Pseudomonas aeruginosa (P. aeruginosa) infections are increasingly challenging due to their propensity form biofilms and low outer membrane permeability, especially in chronically infected patients with thick mucus. P. exhibits multiple drug resistance mechanisms, making it one of the most significant global public health threats. In this study, we found that moxifloxacin (MXC) antibacterial peptides (ε-poly-l-lysine, ε-PLL) exhibited a synergistic effect against multidrug-resistant (MDR-P....
The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell-extracellular matrix interaction adhesion. Here, we report that deleting Pinch1 in limb mesenchymal stem cells (MSCs) Pinch2 globally (double knockout; dKO) mice causes severe chondrodysplasia, while single mutant do not display marked defects. Pinch deletion decreases chondrocyte proliferation, accelerates cell differentiation disrupts column formation. loss drastically reduces Smad2/3 protein expression...
Long noncoding RNAs (lncRNAs) have emerged as diverse functional regulators involved in mammalian development; however, large-scale investigation of lncRNAs spermatogenesis vivo is lacking. Here, we delineated the global lncRNA expression landscape mouse and identified 968 germ cell signature lncRNAs. By combining bioinformatics screening, three ( Gm4665 , 1700027A15Rik 1700052I22Rik ) that directly influence vivo. Knocking down hampered development round spermatids into elongating disrupted...
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At top of this hierarchy lie a series SSC subpopulations. Their individual identities as well relationships with each other, however, remain largely elusive. Using single-cell analysis and lineage tracing, we discovered both in mice humans quiescent subpopulation marked specifically by forkhead box protein C2 (FOXC2). All spermatogenic progenies can be derived...
The intricate interaction between spermatogonial stem cell (SSC) and testicular niche is essential for maintaining SSC homeostasis; however, this remains largely uncharacterized. In study, to characterize the underlying signaling pathways related paracrine factors, we delineated intercellular interactions in both adult mice humans under physiological conditions dissected niche-derived regulation of maintenance recovery conditions, thus uncovering role C-C motif chemokine ligand 24...
FBXO28 is a member of F-box proteins that are the substrate receptors SCF (SKP1, CULLIN1, protein) ubiquitin ligase complexes. Despite implications its role in cancer, function epithelial-mesenchymal transition (EMT) process and metastasis for cancer remains largely unknown. Here, we report critical negative regulator migration, invasion human hepatocellular carcinoma (HCC) vitro vivo. expression upregulated epithelial cell lines relative to mesenchymal counterparts. Mechanistically, by...
Abstract Background Lymph node metastasis (LNM) is the primary mode of in gastric cancer (GC). However, precise mechanisms underlying this process remain elusive. Tumor cells necessitate lipid metabolic reprogramming to facilitate metastasis, yet role lipoprotein lipase (LPL), a pivotal enzyme involved exogenous uptake, remains uncertain tumor metastasis. Therefore, aim study was investigate presence during LNM GC as well LPL process. Methods Intracellular levels were quantified using oil...
Stage IV gastric cancer is a highly heterogeneous and lethal tumor with few therapeutic strategies. The combination of programmed cell death protein 1 inhibitors chemotherapy currently the standard frontline treatment regimen for advanced cancer. Nevertheless, it remains great challenge to screen beneficiaries immunochemotherapy expand indications this regimen.
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At top of this hierarchy lie a series SSC subpopulations. Their individual identities as well relationships with each other, however, remain largely elusive. Using single-cell analysis and lineage tracing, we discovered both in mice humans quiescent subpopulation marked specifically by forkhead box protein C2 (FOXC2). All spermatogenic progenies can be derived...