A5100369226- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Single-cell and spatial transcriptomics
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Hemoglobinopathies and Related Disorders
- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- Nutrition, Genetics, and Disease
- Blood groups and transfusion
- Cancer-related gene regulation
- Genomics and Phylogenetic Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
University of North Carolina at Chapel Hill
2016-2025
Ocean University of China
2018-2025
Capital Medical University
2020-2025
Henan Normal University
2025
Beijing Tongren Hospital
2025
First Affiliated Hospital of Zhengzhou University
2024
People's Liberation Army No. 150 Hospital
2024
Northwest A&F University
2024
Chinese People's Liberation Army
2024
Soochow University
2013-2024
Identifying the genetic variants that increase risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) imputed genotypes for an additional >2 million autosomal SNPs. We carried out analysis these SNPs to identify predispose T2D, compared our results two similar studies, 80 1215 1258 NGT controls....
Identifying reliable biomarkers of aging is a major goal in geroscience.While the first generation epigenetic were developed using chronological age as surrogate for biological age, we hypothesized that incorporation composite clinical measures phenotypic capture differences lifespan and healthspan may identify novel CpGs facilitate development more powerful biomarker
Abstract Genome‐wide association studies (GWAS) can identify common alleles that contribute to complex disease susceptibility. Despite the large number of SNPs assessed in each study, effects most must be evaluated indirectly using either genotyped markers or haplotypes thereof as proxies. We have previously implemented a computationally efficient Markov Chain framework for genotype imputation and haplotyping freely available MaCH software package. The approach describes sampled chromosomes...
It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators proteins including those plasminogen activator inhibitor 1 (PAI-1) growth differentiation factor 15. The lifespan, DNAm GrimAge (in units years), is composite biomarker estimator smoking pack-years. Adjusting for chronological age generated novel measure...
Rare genetic variants contribute to complex disease risk; however, the abundance of rare in human populations remains unknown. We explored this spectrum variation by sequencing 202 genes encoding drug targets 14,002 individuals. find are abundant (1 every 17 bases) and geographically localized, so that even with large sample sizes, variant catalogs will be largely incomplete. used observed patterns estimate population growth parameters, proportion a given frequency class putatively...
Aging | doi:10.18632/aging.101168. Austin Quach, Morgan E. Levine, Toshiko Tanaka, Ake T. Lu, Brian H. Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L. Neuhouser, Jeannette M. Beasley, Linda Snetselaar, Robert B. Wallace, Philip S. Tsao, Devin Absher, Themistocles Assimes, James D. Stewart, Yun Li, Lifang Hou, Andrea A. Baccarelli, Eric Whitsel, Steve Horvath
DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these sub-optimal accuracy in fibroblasts other cell types used ex vivo studies. To address this challenge, we a novel highly robust DNAm age estimator (based on 391 CpGs) human fibroblasts, keratinocytes, buccal cells, endothelial lymphoblastoid skin, blood, saliva samples. High correlations can also be observed sorted neurons, glia, brain, liver, even bone Gestational correlates with...
Obesity is an important component of the pathophysiology chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used assay leukocyte obtained from 2097 African American adults Atherosclerosis Risk Communities (ARIC) study. Mixed-effects regression models were test association beta value concurrent body mass...
New sequencing technologies allow genomic variation to be surveyed in much greater detail than previously possible. While detailed analysis of a single individual typically requires deep sequencing, when many individuals are sequenced it is possible combine shallow sequence data across generate accurate calls shared stretches chromosome. Here, we show that, as progressively larger numbers sequenced, increasingly genotype can generated for given depth. We evaluate the implications...
Telomere length (TL) is associated with several aging-related diseases.Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs.Leukocyte DNAmTL applicable across the entire age spectrum and more strongly than measured leukocyte (LTL) (r ~-0.75 for versus r ~ -0.35 LTL).Leukocyte outperforms LTL in predicting: i) time-to-death (p=2.5E-20),ii) time-tocoronary heart disease (p=6.6E-5),iii) time-to-congestive failure (p=3.5E-6), iv) association smoking history...
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, genetic populations Hispanic/Latino African ancestry are limited. In addition, these more complex linkage disequilibrium structure. order better define the architecture understudied populations, we leveraged >100,000 phased sequences available from deep-coverage whole genome sequencing through multi-ethnic NHLBI Trans-Omics for Precision Medicine (TOPMed) program impute...