A5047086835- Skin Protection and Aging
- Vitamin D Research Studies
- Nonmelanoma Skin Cancer Studies
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders
- Thermoregulation and physiological responses
- Dermatology and Skin Diseases
- Climate Change and Health Impacts
- Genetic and rare skin diseases.
- Effects of Radiation Exposure
- Cancer and Skin Lesions
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Epigenetics and DNA Methylation
- Optical Imaging and Spectroscopy Techniques
- Reconstructive Facial Surgery Techniques
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Tumors and Oncological Cases
- Nuclear Structure and Function
- Wound Healing and Treatments
- Circadian rhythm and melatonin
- Renal cell carcinoma treatment
- Medical and Biological Ozone Research
- Empathy and Medical Education
University of British Columbia
2024-2025
British Columbia Children's Hospital
2024
Churchill Hospital
2018-2022
Oxford University Hospitals NHS Trust
2016-2022
University of Oxford
2014-2021
Salford Royal NHS Foundation Trust
2012-2020
University of Manchester
2012-2020
Manchester Academic Health Science Centre
2012-2020
The University of Texas Southwestern Medical Center
2016
University of Salford
2014
DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these sub-optimal accuracy in fibroblasts other cell types used ex vivo studies. To address this challenge, we a novel highly robust DNAm age estimator (based on 391 CpGs) human fibroblasts, keratinocytes, buccal cells, endothelial lymphoblastoid skin, blood, saliva samples. High correlations can also be observed sorted neurons, glia, brain, liver, even bone Gestational correlates with...
The concurrent impact of repeated low-level summer sunlight exposures on vitamin D production and cutaneous DNA damage, potentially leading to mutagenesis skin cancer, is unknown.This an experimental study (i) determine the dual status damage/repair (via both urinary biomarkers) in light-skinned adults; (ii) compare outcomes following same brown-skinned adults.Ten white (phototype II) six South Asian volunteers V), aged 23-59 years, received 6 weeks' simulated (95% ultraviolet A/5% B, 1·3...
Abstract Increasing evidence regarding positive effects of exposure to sunlight has led suggestions that current advice may be overly weighted in favour avoidance. UV-A been reported lower blood pressure, possibly through nitric oxide (NO) production skin. Here, we set out investigate and solar-simulated radiation on the potential source dermal NO, effective doses wavelengths, responsiveness different human skin cells, magnitude inter-individual differences influence age. We utilised...
Complete surgical excision of melanoma in situ (MIS) is curative. A 5-mm margin often taken as the standard primary despite increasing evidence that this frequently inadequate for tumor clearance.To calculate proportion patients requiring >5 mm clearance and to investigate any patient/lesion characteristics necessitating larger margins.Three hundred forty-three MIS cases on head neck treated authors' department by Mohs micrographic surgery (MMS) over a 65-month period were retrospectively...
ABSTRACT Congenital erosive and vesicular dermatosis (CEVD) is a rare condition that typically presents at birth with erosions vesicles heal distinctive reticulate supple scarring. We report two cases of CEVD in term infants, both which exhibited unique features. The first patient presented linear healed without vesiculation, the second stellate scarring milia. As there was no clear history vesiculation our patients, we suggest congenital eruption (CEASE) may better reflect this subset CEVD.
Voriconazole, a broad-spectrum triazole antifungal agent increasingly used to treat aspergillosis, has been linked with acute photosensitivity and skin carcinogenesis. The action spectrum of the is unknown, while an indirect retinol effect secondary antifungal's impact on CYP450 enzymes proposed contribute underlying mechanism.To perform detailed photobiological assessment presenting in series 12 patients treated voriconazole.Minimal erythemal dose thresholds (MED) narrow wavebands...
Low vitamin D status is prevalent in wintertime populations at northerly latitudes. Photosensitive patients are advised to practise sun avoidance, but their sunlight exposure levels, photoprotective measures and resulting unknown. To examine seasonal photosensitive relative healthy individuals assess quantitatively behavioural demographic contributors. This was a longitudinal prospective cohort study (53·5°N) examining year‐round 25‐hydroxyvitamin [25(OH)D] sun‐exposure behaviour oral intake...
Over the past decades, there have been huge advances in understanding cellular responses to ionising radiation (IR) and DNA damage. These studies, however, were mostly executed with cell lines mice using single or multiple acute doses of radiation. Hence, relatively little is known about how continuous exposure low dose affects normal cells organisms, even though our are constantly exposed levels We addressed this issue by examining consequences exposing human primary γ-radiation delivered...
Evidence suggests that exposure to UV-A radiation can liberate nitric oxide from skin cells eliciting vasodilation in-vivo. However, the duration of release in after UV is not well studied, with emphasis on UV-B mediated iNOS upregulation. The current study demonstrated persistence a dark reaction moderate exposure, peaking around 48 h post exposure; this effect was shown keratinocytes, fibroblasts and endothelial neonatal donors keratinocytes aged confirmed hypothesis appeared upregulate...
Naevus sebaceous (NS) is a congenital cutaneous hamartoma, which typically occurs on the head and neck. Historically, treatment of choice was excision in infancy because potential for malignant transformation; however, recent studies suggest that this risk < 1% unlikely childhood. We sent questionnaire to UK dermatologists plastic surgeons investigate current management practice NS. found almost third still recommend malignancy prevention, while over 90% consider excision, with 64% citing...
Vulval allergic contact dermatitis (ACD) may be a primary disorder or associated with an underlying vulval dermatosis. Few studies have looked at the incidence of ACD and allergens responsible for it.We report in 282 patients investigated over 6-year period large teaching hospital.We performed retrospective case notes review all symptoms our tertiary referral investigation unit. A total underwent patch testing.The overall was 54%. The age range 14-89 years. Pruritus most common presenting...
Tanning (melanisation and epidermal thickening) is a photoprotective response to solar UVR exposure, but it's unclear what degree low-level exposures induce this in light-skin individuals, or whether modifies the histological inflammatory UVR. Objectives were examine if, people, simulated summer's casual sunlight induces (i) melanogenesis, (ii) thickening (iii) demonstrable protection against both clinical (erythema) (neutrophil infiltration) impacts of higher-level, pro-inflammatory...
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Inflammatory bowel disease has been associated with a number of cutaneous and systemic neutrophilic disorders, including pyoderma gangrenosum. In 1972, the term chronic multi-focal recurrent osteomyelitis was given to sterile condition which inflammatory disease.We report case 23-year-old man long-standing severe Crohn's necessitated subtotal colectomy. He subsequently developed progressive, intermittent back pain that were limiting his functional movement. Numerous investigations identify...
We have developed a technique to isolate primary keratinocytes, melanocytes, fibroblasts, preadipocytes, and microvascular endothelial cells from an individual sample of human skin. The protocol describes step-by-step instructions for processing, isolation, culture neonatal foreskin, with adaptation more demanding adult tissues. availability multiple isogenic cell types derived skin samples offers the ability investigate various areas biology, in context cell-type specificity without...