A5102903081- Vitamin D Research Studies
- Bone health and osteoporosis research
- Climate Change and Health Impacts
- Nutritional Studies and Diet
- Vitamin C and Antioxidants Research
- Adrenal Hormones and Disorders
- Veterinary Oncology Research
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Veterinary Medicine and Surgery
- Bone health and treatments
- Stress Responses and Cortisol
- Skin Protection and Aging
- Biotin and Related Studies
- Dermatology and Skin Diseases
- Healthcare cost, quality, practices
- Ion channel regulation and function
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Meta-analysis and systematic reviews
- Thyroid Disorders and Treatments
- HIV-related health complications and treatments
- Folate and B Vitamins Research
- Cardiac electrophysiology and arrhythmias
- Monoclonal and Polyclonal Antibodies Research
Manchester Royal Infirmary
2008-2021
University of Manchester
2008-2020
Manchester Academic Health Science Centre
2010-2018
Manchester University NHS Foundation Trust
2018
St Mary's Hospital
2009
Roslin Institute
2009
University of Edinburgh
2009
King's College London
2009
University of Cambridge
2006
Harvard University
2006
Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies evaluate effect of vitamin supplementation on antimycobacterial immunity have not previously been performed.To determine and status.A double-blind randomized controlled trial conducted 192 healthy adult TB contacts London, United Kingdom. Participants were receive a single oral dose 2.5 mg or placebo followed up at 6 weeks.The primary outcome measure assessed with functional whole blood assay (BCG-lux...
There has been a resurgence of vitamin D deficiency among infants, toddlers, and adolescents in the United Kingdom. Myopathy is an important clinical symptom deficiency, yet it not widely studied.Our objective was to investigate relationship baseline serum 25 hydroxyvitamin [25(OH)D] concentration PTH with muscle power force.This cross-sectional study.The study community based secondary school.A total 99 post-menarchal 12- 14-yr-old females included study.Jumping mechanography measure power,...
graft failure or disease relapse.
<h3>Background</h3> Adipose-derived cytokines, including tumor necrosis factor α, may contribute to the inflammation that occurs in metabolic syndrome. We investigated effects of inhibition α with etanercept patients <h3>Methods</h3> Fifty-six subjects syndrome were randomized administration either or identical placebo, 50 mg subcutaneously once a week for 4 weeks. The C-reactive protein level was primary end point. Effects on other inflammatory markers (including fibrinogen, interleukin 6,...
Abstract Objective Previous in vitro and animal studies have suggested that vitamin D, particular, its metabolite 25‐hydroxyvitamin D (25[OH]D), may immunomodulatory effects. To study further the potential effects of humans, we explored hypothesis serum metabolites be inversely associated with current disease activity, severity, functional disability patients early inflammatory polyarthritis (IP). Methods We studied 206 consecutive IP who were enrolled Norfolk Arthritis Register between...
Background Vitamin D is necessary for bone health and potentially protective against a range of malignancies. Opinions are divided on whether the proposed optimal circulating 25‐hydroxyvitamin [25(OH)D] level (≥ 32 ng mL−1) an appropriate feasible target at population level. Objectives We examined personal sunlight exposure levels can provide vitamin sufficient 20 status in U.K. public. Methods This prospective cohort study measured 25(OH)D monthly 12 months 125 white adults aged 20–60 years...
The Rank Forum on Vitamin D was held 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. workshop consisted a series scene-setting presentations to address current issues challenges concerning vitamin health, included an open discussion focusing identification concentrations serum 25-hydroxyvitamin (25(OH)D) (a marker status) that may be regarded as optimal, implications this process have in setting future dietary reference values for agreement with fact it is desirable all...
Exposure to sunlight, specifically the ultraviolet radiation, has both positive and negative health effects. Maximizing benefits (vitamin D synthesis) while minimizing damage is a multifaceted problem in which many of elements are poorly quantified. Here we show how rigorously conducted large sample size laboratory studies effect radiation dose on vitamin status can be applied real-life situations. This was achieved by modeling incident different surfaces for solar locations, equating with...
The concurrent impact of repeated low-level summer sunlight exposures on vitamin D production and cutaneous DNA damage, potentially leading to mutagenesis skin cancer, is unknown.This an experimental study (i) determine the dual status damage/repair (via both urinary biomarkers) in light-skinned adults; (ii) compare outcomes following same brown-skinned adults.Ten white (phototype II) six South Asian volunteers V), aged 23-59 years, received 6 weeks' simulated (95% ultraviolet A/5% B, 1·3...
Vitamin D metabolites were measured on admission in eight patients intoxicated with ergocalciferol (serum calcium 3.01-4.05 mmol/l) and also during the subsequent 2 months six of eight. Serum concentrations 25-hydroxyergocalciferol, admission, grossly elevated all (range 583-1843 nmol/l). concentration was related significantly only to 25-hydroxyergocalciferol (P = 0.003). Concentrations serum those calciferol 0.004). Elevated initial 1,25-dihydroxycalciferol, mainly as...
Public health guidance recommends limiting sun exposure to sub-sunburn levels, but it is unknown whether these can gain vitamin D (for musculoskeletal health) while avoiding epidermal DNA damage (initiates skin cancer). Well-characterized healthy humans of all types (I–VI, lightest darkest skin) were exposed a low-dose series solar simulated UVR 20%–80% their individual sunburn threshold dose (minimal erythema dose). Significant responses seen for serum 25-hydroxyvitamin and whole...
Background Dogs with a chronic enteropathy ( CE ) have lower vitamin D status, than do healthy dogs. Vitamin status has been associated negative clinical outcome in humans inflammatory bowel disease. Objectives To examine the relationship between serum 25 hydroxyvitamin (25( OH )D) concentrations at diagnosis and dogs . Animals Forty‐one diagnosed admitted to Royal Dick School of Veterinary Studies, Hospital for Small 2007 2013. Methods Retrospective review. Serum 25( )D were compared which...
Serum vitamin D metabolites and PTH were measured in seven subjects with a history of previous partial gastrectomy (PGX) metabolic bone disease. The elimination t1/2 of[ 3H]25-hydroxyvitamin D3 ([3H]25OHD3) serum was assessed after an iv pulse dose 5 μCi [26,27-3H]25OHD3. Median 25OHD3 37.5 (27.5–101.3) nmol/L, [normal range (NR) 10.8–58.5 nmol/L], mean 1,25-dihydroxyvitamin [1, 25-(OH)2D3] raised at 175 ± 72 pmol/L, (NR 48–120 pmol/L) also high, 67 27 ng/L, 10–60 ng/L). t1/2[ 3H]25OHD3...
Pseudovitamin D-defiency rickets (PDDR) is an autosomal recessive disorder characterized by hypocalcemia, (which are resistant to treatment with vitamin D), and low or undetectable serum levels of 1,25-dihydroxyvitamin D (1,25(OH)2D). The symptoms corrected 1,25(OH)2D treatment, the disease now believed result from a defect in cytochrome P450 component (P450c1; CYP27B1) renal 25-hydroxyvitamin D-1alpha-hydroxylase (1-OHase). We have studied genomic DNA three families PDDR identified same...
Introduction Vitamin D deficiency, as assessed by serum concentrations of 25 hydroxyvitamin (25(OH)D), has been linked to the development over-zealous and inappropriate inflammation in humans. However, relationship between vitamin status dogs is ill-defined. Chronic enteropathies (CE) are frequently diagnosed client owned dogs, have a wide range 25(OH)D concentrations, represent spontaneous model which probe inflammation. The hypothesis this study was that would be negatively associated with...