A5053596593- Liver Disease and Transplantation
- Veterinary Medicine and Surgery
- Liver Disease Diagnosis and Treatment
- Veterinary Oncology Research
- Vitamin D Research Studies
- Veterinary Orthopedics and Neurology
- Iron Metabolism and Disorders
- Adrenal Hormones and Disorders
- Blood groups and transfusion
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Conditions and Treatments
- Human-Animal Interaction Studies
- Viral gastroenteritis research and epidemiology
- Trace Elements in Health
- Potassium and Related Disorders
- Intestinal and Peritoneal Adhesions
- Magnesium in Health and Disease
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Gut microbiota and health
- Pancreatitis Pathology and Treatment
- Animal Behavior and Welfare Studies
- Veterinary Equine Medical Research
- Clinical Laboratory Practices and Quality Control
- Intestinal Malrotation and Obstruction Disorders
Roslin Institute
2014-2024
University of Edinburgh
2014-2024
Zoetis (United Kingdom)
2024
Scotland's Rural College
2018
Hudson Institute
2016
John Wiley & Sons (United States)
2016
Texas A&M University
2015
Royal Edinburgh Hospital
2008
In morphological terms, "form" is used to describe an object's shape and size. dogs, facial form stunningly diverse. Facial retrusion, the proximodistal shortening of snout widening hard palate common brachycephalic dogs a welfare concern, as incidence respiratory distress ocular trauma observed in this class highly correlated with their skull form. Progress identify molecular underpinnings retrusion limited association missense mutation BMP3 among small dogs. Here, we morphometrics...
Objectives: To compare serum vitamin D metabolites and plasma parathyroid hormone concentrations in dogs with inflammatory bowel disease normal albumin concentration, hypoalbuminaemia, healthy hospitalised ill non-gastrointestinal illness. Methods: Serum 25 hydroxyvitamin 1,25 dihydroxyvitamin were measured 36 dogs, 49 illnesses, 21 normoalbuminaemia 12 hypoalbuminaemia. Plasma ionised calcium a subset of these dogs. Results: Concentrations lower hypoalbuminaemic than the (P<0·001),...
Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with liver disease. The pathogenesis he incompletely understood although ammonia inflammatory cytokines have been implicated as key mediators. To facilitate further mechanistic understanding the HE, a large number animal models developed which often involve surgical creation anastomosis between hepatic portal vein caudal vena cava. One most common congenital abnormalities dogs portosystemic shunt (cpss),...
Background Dogs with a chronic enteropathy ( CE ) have lower vitamin D status, than do healthy dogs. Vitamin status has been associated negative clinical outcome in humans inflammatory bowel disease. Objectives To examine the relationship between serum 25 hydroxyvitamin (25( OH )D) concentrations at diagnosis and dogs . Animals Forty‐one diagnosed admitted to Royal Dick School of Veterinary Studies, Hospital for Small 2007 2013. Methods Retrospective review. Serum 25( )D were compared which...
Introduction Vitamin D deficiency, as assessed by serum concentrations of 25 hydroxyvitamin (25(OH)D), has been linked to the development over-zealous and inappropriate inflammation in humans. However, relationship between vitamin status dogs is ill-defined. Chronic enteropathies (CE) are frequently diagnosed client owned dogs, have a wide range 25(OH)D concentrations, represent spontaneous model which probe inflammation. The hypothesis this study was that would be negatively associated with...
Faecal samples were collected from 57 clinically healthy kittens presented for initial vaccination, in the UK. Routine bacteriological examination identified Salmonella species one and Campylobacter five samples. Polymerase chain reaction (PCR) detected presence of a further four parasitological revealed Toxocara ova nine (including stated to have been administered an anthelmintic) Isospora No Giardia or Cryptosporidium by routine methods. A enzyme-linked immunosorbent assay (ELISA) test kit...
Current tests for diagnosing liver disease in dogs are sub-optimal. MicroRNA-122 (miR-122) is a sensitive and specific biomarker of injury humans rodents. Circulating miR-122 could have utility identifying with disease.Establish the reference interval healthy determine performance range dog breeds control animals non-liver disease.Stored serum from 120 dogs, 100 diseases, 30 histologically confirmed was analyzed.Retrospective study. Medical records disease, were reviewed. Serum...
Abstract Background Numerous studies in veterinary species have recently linked vitamin D status with nonskeletal health disorders. Previous indicated that dogs cannot produce endogenous via cutaneous production and rely solely on dietary intake of D. The seasonal variation seen humans due to changes ultraviolet (UV) exposure, therefore, is unlikely be replicated these animals. Objectives objective this study was investigate the natural 25‐hydroxyvitamin‐D concentrations subject UV exposure....
Background There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and dogs. Vitamin influences cellular function by signaling through the receptor (VDR). Little known about which non‐skeletal tissues express VDR or how inflammation its expression dog. Objectives To define canine investigate inflamed small intestine. Animals Thirteen were collected prospectively from 6 control Thirty‐five dogs diagnosed with a chronic enteropathy (CE) 24 enrolled...
Abstract Background Pancreatitis is an important cause of disease and death in dogs. Available circulating biomarkers are not sufficiently sensitive specific for a definitive diagnosis. Hypothesis Circulating microRNAs would be differentially expressed dogs with chronic pancreatitis could have potential as diagnostic biomarkers. Animals Healthy controls (n = 19) naturally occurring 17). Methods A retrospective case‐control study. Dogs were included if they satisfied criteria adjudicated by 3...
Manganese (Mn) is an essential mineral that a cofactor for many enzymes required in the synthesis of proteins, carbohydrates, and lipids. Because hepatic clearance Mn homeostasis, conditions humans resulting insufficiency including cirrhosis both acquired congenital portosystemic shunting have been reported to result increased blood concentrations content central nervous system. toxicity causes neurologic disturbances, implicated pathogenesis encephalopathy.Dogs with shunts (cPSS)...
Abstract Background Protein‐losing enteropathy (PLE) because of chronic inflammatory (CIE) in dogs is often treated with a combination glucocorticoids and second‐line immunosuppressant (SLI). This combined approach might not be necessary all dogs. Hypothesis/objectives To describe diagnostic features outcomes PLE alone (group P) or SLI S). Animals Thirty‐one PLE. Material methods Retrospective analysis signalment data from procedures, treatment, outcome CIE/PLE (from 2015 to 2017), using the...
A six‐year‐old neutered male Jack Russell terrier was presented two years after importation into the UK from southern Africa with severe anaemia and abdominal distension. Abdominal ultrasonography revealed presence of hepato‐splenomegaly ascites. diagnosis trypanosomosis made by blood smear examination. Shortly admission dog collapsed died. PCR analysis a single infection Trypanosoma congolense savannah type. This is first reported case canine African in Europe suggests that chronic may...
The concentrations of C-reactive protein (CRP), serum amyloid A, haptoglobin (Hp) and α(1)-acid glycoprotein were measured in dogs with clinical signs nasal disease compared those healthy order to determine the expression these proteins cases canine disease. A significant difference (P<0.001) between symptomatic group control was found for both CRP Hp. Among animals disease, a intergroup (P<0.05) Hp aspergillosis chronic rhinitis.
The assessment of serum cardiac troponin I concentrations in dogs with a range nonprimary illnesses has revealed that myocyte damage is commonplace many canine diseases. Whilst it well established fatal immune-mediated haemolytic anaemia frequently have pathology based on post-mortem examinations, there limited information the incidence this population dogs.Serum were measured 11 healthy dogs, 27 primary and 49 hospitalised without or haematological disorders.Dogs higher than ill (P<0.005)...
Liver disease is a major cause of morbidity and mortality. One the most significant complications in patients with liver development neurological disturbances, termed hepatic encephalopathy. The pathogenesis encephalopathy incompletely understood, which has resulted wide range experimental models. Congenital portosystemic shunt one common congenital disorders diagnosed client owned dogs. Our recent studies have demonstrated that pathophysiology canine very similar to human encephalopathy,...
Urine dipstick results may vary between operators/methods. The magnitude of variation across the veterinary field is currently unknown. aim this study was to compare precision urine standard direct visual and automated reading methods when performed by several operators. samples were pooled divided into three aliquots: one plain, with glucose serum. Final year students, surgeons nurses, blinded each sample, then asked perform analysis visualisation an analyser, their technique observed. A...
Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs approximately 30 per cent cases. The pathogenesis with hypoadrenocorticism unknown. This case series reports ionised calcium, parathyroid hormone, hormone-related protein vitamin D metabolite concentrations...
Colony stimulating factor (CSF-1) and its receptor, CSF-1R, have been previously well studied in humans rodents to dissect the role they play development of cells mononuclear phagocyte system. A second ligand for IL-34 has described several species. In this study, we cloned expressed feline CSF-1R examined responsiveness CSF-1 from a range The results indicate that pig human are equally effective cats, where both mouse significantly less active. Recombinant can be used generate populations...
Resting cortisol concentrations are routinely measured in dogs with chronic gastrointestinal signs to rule out hypoadrenocorticism based on a concentration >2 μg/dL (>55 nmol/L).To assess the cross-sectional prevalence of group presented referral internal medicine service.Two-hundred and eighty-two client-owned resting testing performed.Retrospective review medical records (final diagnosis, concentration, adenocorticotropic hormone [ACTH] stimulation test results) population between May 2013...