A5033034297- Veterinary Oncology Research
- Cystic Fibrosis Research Advances
- Veterinary Orthopedics and Neurology
- Microbial infections and disease research
- Vector-Borne Animal Diseases
- Cardiovascular Effects of Exercise
- Renal cell carcinoma treatment
- Virus-based gene therapy research
- Genetic Mapping and Diversity in Plants and Animals
- Veterinary Equine Medical Research
- Genetic and phenotypic traits in livestock
- Occupational and environmental lung diseases
- Animal health and immunology
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- Sports injuries and prevention
- Tendon Structure and Treatment
- Economic and Financial Impacts of Cancer
- Parasitic Infections and Diagnostics
- Gun Ownership and Violence Research
- melanin and skin pigmentation
- RNA Interference and Gene Delivery
- Cardiovascular Conditions and Treatments
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
University of Edinburgh
2013-2024
Roslin Institute
2013-2024
Scotland's Rural College
2010-2020
The Royal Free Hospital
2018-2019
University College London
2018-2019
NHS Greater Glasgow and Clyde
2019
NHS Dumfries and Galloway
2017
Hebrew University of Jerusalem
2016
University of Cambridge
2016
Queen's Hospital
2016
Helicobacter pylori causes chronic (type B) gastritis. The 9intestinal9 form of gastric cancer arises against a background gastritis, and prospective epidemiological studies have shown that H is major risk factor for this. An increase in mucosal cell proliferation increases the likelihood neoplastic clone epithelial cells emerging where there injury associated with In vitro bromodeoxyuridine labelling endoscopic antral biopsy specimens was used to measure gastritis before after therapy...
Abstract In this paper entitled “Tuberculin Type Sensitivity to Spinal Cord Antigen in Rabbits with Isoallergic Encephalomyelitis” by Byron H. Waksman and L. Raymond Morrison, Journal of Immunology 66: 421–444, April, 1951, the titles Figures 3 4 on page 430 were reversed.
Damage to the nervous system as a consequence of anoxia has been produced in many ways, but most investigations dealing with this subject have borne slight relation problem aviation. Illuminating and important these previous clinical experimental studies been, they not, few exceptions, concerned precisely conditions met The purpose present investigation was determine whether histologic alterations were central after repeated, sublethal exposures an atmosphere deficient oxygen; measure amount...
THE ACUTE disseminated encephalomyelitis that sometimes follows vaccination against rabies<sup>1</sup>or smallpox,<sup>2</sup>as well as the postinfectious following exanthematous diseases, bears such an apparently close relation to multiple sclerosis, Schilder's disease (progressive subcortical encephalopathy) and other demyelinating processes in central nervous system it has attracted attention of numerous investigators recent years. But was 1895 Pierre Marie<sup>3</sup>first stressed...
Summary In rabbits with experimental isoallergic encephalomyelitis, intracutaneous tests homologous spinal cord suspended in saline gave reactions having the gross and histologic characteristics of tuberculin response. Skin reactivity could not be passively transferred large amounts serum. The development skin was correlated disease, both degree time. Positive corneal demonstrated approximately one half to third animals developing especially those surviving longer than 2 weeks. Titration...
DEMYELINATING diseases still constitute one of the major problems neurology, and lack knowledge concerning their etiology is a constant handicap to rational therapy. The various manifestations myelin degradation, as observed in different demyelinating diseases, have been explained by divers causes: mechanical, chemical, infectious, immunologic hereditary. variety mechanisms underlying breakdown apparently so great that wonders with Hurst 1 whether demyelination not type response nervous...
Lumpy skin disease is a high-consequence in cattle caused by infection with the poxvirus lumpy virus (LSDV). The endemic most countries Africa and an emerging threat to populations Europe Asia. As LSDV spreads into new regions, it important that signs of are recognized promptly animal caregivers. This study describes gross, microscopic, ultrastructural changes occur over time experimentally challenged LSDV. Four calves were inoculated wildtype monitored for 19 21 days. At 7 days after...
Standardised histological criteria are now available for the diagnosis of canine chronic hepatitis (CH). CH is common in dogs, but no studies have reported breed, age and gender distributions United Kingdom (UK). The objective this study was to determine which breeds had an increased risk developing UK report distribution those breeds. databases six veterinary histopathology laboratories were searched cases with a according standardised criteria. dogs recorded compared control population...
Abstract WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during embryonic development and, if mutated, can lead to formation of Wilms’ tumour, most common paediatric kidney cancer. Its expression has also been reported in several adult tumour types, including breast cancer, and usually correlates with poor outcome. However, published data inconsistent role this malignancy remains unclear. Here we provide complete study across different cancer subtypes as well...
The incidence of peritonitis ranges from 1 episode every 24 patient treatment months to 60 [Keane WF, et al. ISPD Guidelines/Recommendations. Adult peritoneal dialysis-related recommendations: 2000 update. Perit Dial Int 2000; 20:396-411.]. Gram-positive organisms account for over 80% continuous ambulatory dialysis (PD)-associated peritonitis. Recent fear vancomycin-resistant enterococci (VRE) has prompted suggestions limiting vancomycin use. Fifty-one episodes in 30 patients studied 2 years...
The aims of this study were to establish expression epidermal growth factor receptor (EGFR) and Ki67 in 67 archived biopsy samples feline oral squamous cell carcinomas (FOSCCs) if the either markers was predictive survival. Samples immunohistochemically labelled for two proteins scored. Statistical analyses data, including Kaplan–Meier survival curves, performed. All expressed both although levels differed between samples. Median overall 46 days 1‐year 5%. There no correlation EGFR scores...
Dogs with protein-losing enteropathy (PLE) are suggested to be at increased risk of developing thromboembolic events. However, some exceptions, there very few reports thromboembolism in such dogs. This multicentre retrospective observational study describes a case series (TE) eight dogs PLE secondary non-neoplastic, chronic small intestinal disease. Seven had poorly controlled when the event occurred. Pulmonary (PTE) occurred six dogs, while one dog developed splenic vein thrombosis and...
Abstract Real‐time monitoring of tumor microenvironment parameters using an implanted biosensor could provide valuable information on the dynamic nature a tumor's biology and its response to treatment. However, following implantation biosensors may lose functionality due biofouling caused by foreign body (FBR). This study developed novel xenograft model evaluate potential six biomaterials (silicon dioxide, silicon nitride, Parylene‐C, Nafion, biocompatible EPOTEK epoxy resin, platinum)...
Abstract Background Protein‐losing enteropathy (PLE) because of chronic inflammatory (CIE) in dogs is often treated with a combination glucocorticoids and second‐line immunosuppressant (SLI). This combined approach might not be necessary all dogs. Hypothesis/objectives To describe diagnostic features outcomes PLE alone (group P) or SLI S). Animals Thirty‐one PLE. Material methods Retrospective analysis signalment data from procedures, treatment, outcome CIE/PLE (from 2015 to 2017), using the...
Abstract Background Equine grass sickness (EGS) is a frequently fatal multisystem neuropathy of equids. The aetiology unknown; proposed causes include toxicoinfection with Clostridium botulinum and mycotoxicosis. effect EGS on the organisation structural integrity skeletal neuromuscular junction (NMJ), target neurotoxins (BoNTs), unknown. Objectives To compare NMJs from horses, control horses one horse presumptive diagnosis botulism. Study design Blinded, retrospective case control. Methods...