A5023118281- Veterinary Equine Medical Research
- Helminth infection and control
- Plant and fungal interactions
- Exercise and Physiological Responses
- Diphtheria, Corynebacterium, and Tetanus
- Coccidia and coccidiosis research
- Plant Toxicity and Pharmacological Properties
- Botulinum Toxin and Related Neurological Disorders
- Clostridium difficile and Clostridium perfringens research
- Animal health and immunology
- Effects of Environmental Stressors on Livestock
- Reproductive Physiology in Livestock
- Hereditary Neurological Disorders
- Asthma and respiratory diseases
- Ruminant Nutrition and Digestive Physiology
- Microbial infections and disease research
- Vector-Borne Animal Diseases
- Immune Response and Inflammation
- Vector-borne infectious diseases
- Muscle metabolism and nutrition
- Veterinary medicine and infectious diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Voice and Speech Disorders
- Animal Nutrition and Physiology
- Neurological diseases and metabolism
University of Edinburgh
2015-2025
Roslin Institute
2013-2024
British Veterinary Association
2023
Scotland's Rural College
1993-2017
University of California, Davis
2010
Central Veterinary Research Laboratory
2010
Wellcome Centre for Cell Biology
2001-2007
Edinburgh College
2006
Newmarket Equine Hospital
2004
Wellcome Trust
1998-2003
Of 400 horses referred because of equine dental disease, 162 suffered from primary apical infections their cheek teeth (CT), including 92 with maxillary CT and 70 mandibular infections. Maxillary swellings sinus tracts were more common (82 26% incidence, respectively) the rostral 3 CT, than caudal (39 5% respectively). Nasal discharge was commonly present (95%) (23%) Mandibular had (91%) (59%) these closely related to eruption affected CT. A variety treatments, medical treatment, curettage,...
Eight control and 8 asymptomatic COPD-affected horses were given, on separate occasions, inhalation challenges with extracts of Micropolyspora faeni, Aspergillus fumigatus Thermoactinomyces vulgaris. All also given nebulised phosphate-buffered saline (PBS) 'natural challenges' (NCs), i.e. exposure to hay straw, as challenges. Responses assessed by clinical, pulmonary mechanics, arterial blood gas tensions, pH bronchoalveolar lavage fluid cytological examinations. PBS had no effect or horses,...
Summary Background Equine heaves is a naturally occurring organic dust‐induced asthma characterized by airway neutrophilia, mucus hypersecretion and obstructive lung dysfunction. However, the relative role of different dust components in disease severity remains unclear. Objective This study investigated contribution inhaled endotoxin particulates (mainly mould spores) inducing heaves‐susceptible horses. Methods Control horses received inhalation challenges with hay suspension (HDS) before...
Reasons for performing study: To improve the understanding of exercise related sudden death in Thoroughbred racehorses. Objectives: describe post mortem findings cases associated with 268 Methods: Gross and histological were collated reviewed. Cases originated from 6 racing jurisdictions around world. Sudden was defined as acute collapse a closely observed previously apparently healthy racehorse, during, or within one hour after, exercise. Cause determined by attending pathologist...
Abstract Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog this virus, termed canine hepacivirus (CHV) and found respiratory secretions dogs, provides evidence for wider distribution hepaciviruses mammals. We determined frequencies active infection among dogs other mammals United Kingdom. Samples from (46 respiratory, 99 plasma, 45 autopsy samples) were CHV negative by PCR. Screening 362 samples cats, horses, donkeys, rodents, pigs identified...
Non-primate hepacivirus (NPHV), equine pegivirus (EPgV) and Theiler's disease associated virus (TDAV) are newly discovered members of two genera in the Flaviviridae family, Hepacivirus Pegivirus respectively, that include human hepatitis C (HCV) (HPgV). To investigate their epidemiology, persistence clinical features infection, large cohorts horses other mammalian species were screened for NPHV, EPgV TDAV viraemia past exposure through serological assays NPHV EPgV-specific antibodies....
Of 400 horses referred because of dental disorders, 349 cases were diagnosed as suffering from primary disorders their cheek teeth. Details 104 these are presented, including 44 with abnormalities wear, 26 traumatic damage, 24 idiopathic fractures and 10 miscellaneous teeth oral tumours. The long-term response to treatment was excellent in most cases, even residual secondary periodontal disease.
Of 400 referred horses with dental disorders, 349 cases suffered from primary disorders of their cheek teeth, ninety these development or eruption, displacements. These included 20 rostral maxillary and caudal mandibular teeth overgrowths, 16 diastemata, 15 grossly enlarged 'eruption cysts', 4 10 supernumerary 23 displaced teeth. displacements were believed to be developmental in acquired the remaining 7 cases. Long-term response treatments, that removal overgrowths extraction deep secondary...
Summary Referred cases (n = 375) of laryngeal paralysis (1985–1998) from a mixed‐breed equine population included 351 (94%) recurrent neuropathy (RLN) (idiopathic hemiplegia) and 24 (6%) causes other than RLN. Laryngeal movements were classified endoscopically into one 6 grades, in contrast to the usual 4 grades. The RLN had median grade paralysis, which 96% left‐sided, 2% right‐sided bilaterally affected. 204 (58%) Thoroughbred, 96 (27%) Thoroughbred‐cross, 23 (7%) draught, 16 (5%)...
Summary Reasons for performing study : Laryngoplasty (LP) is currently the most common surgical treatment equine laryngeal paralysis, however, there have been no reports quantifying degree of retention arytenoid abduction following L P. ADitionally, complications LP poorly documented. Objectives To record and to accurately document all surgery. Methods A (1986–1998) 200 horses mixed breed workload, median age 6 years (prospective 136 cases retrospective 64 cases) undergoing (using 2...
Summary Reasons for performing study: Improved understanding of the epidemiology atypical myopathy (AM) will help to define environmental factors that permit or support causal agent(s) exert toxicity. Objectives: This European survey AM aimed describe spatiotemporal distribution, survival, clinical signs, circumstances in which develops and its different expressions between countries over time. Methods: The history features cases reported Atypical Myopathy Alert Group from 2006 2009 were...
Anthelmintic resistance in equine gastrointestinal nematodes is a threat to health and welfare. Detailed knowledge of anthelmintic use parasite control methods prerequisite identification potential risk factors for resistance.To identify practices employed by owners Scotland investigate management associated with resistance.Questionnaire study Scotland.Questionnaires were available electronically, distributed at conference mailed clients. Key areas explored included general background,...
Despite increasing awareness within the veterinary profession and equine industry of potential implications anthelmintic resistance (AHR), there is a concern that insufficient measures are being taken to reduce its development spread. This document was commissioned provide surgeons with up date information on worm control plans will prevent clinical disease while minimising selection pressure for resistance. Recommendations were developed using an informal two-round Delphi process,...
Summary There is a paucity of literature describing equine lipoid pneumonia (LP) caused by inadvertent intrapulmonary administration liquid paraffin (mineral oil). This case report improves our understanding LP describing; (1) the first reported return horse to racing after LP, (2) likely benefits prolonged dexamethasone administration, (3) detailed short‐ and long‐term pulmonary systemic responses (4) retention paraffin.
Summary To investigate whether inhaled endotoxin contributes to airway inflammation and dysfunction in stabled horses, control (n = 6) asymptomatic heaves (previously termed chronic obstructive pulmonary disease)‐susceptible 7) horses were given inhalation challenges with 20, 200 2000 μg of soluble Salmonella typhimurium Ra60 lipopolysaccharide (LPS). LPS induced a dose‐dependent neutrophilic inflammatory response both groups. Inhalation also detectable lung the group. did not alter clinical...
A review of 400 horses referred because dental disorders showed 44 cases to suffer from primary their incisors and 11 canine or 1st premolar teeth disorders. The remaining 345 suffered the cheek teeth. Disorders included traumatic damage supporting bones, retained deciduous, displaced supernumerary incisors; brachygnathia abnormalities wear, with most latter being secondary Only 3 apical infection were recognised. Most fractured responded well conservative therapy. Retained deciduous...
Three-hundred adult horses, referred from 1990 to 1993 inclusively, for pulmonary examination were assessed using standardised history taking and clinical, intrapleural pressure, arterial blood gases pH, bronchoscopic tracheal broncho-alveolar lavage fluid (BALF) cytological examinations. Two-hundred thirty-five cases with overt signs of disease the remaining 65 because reduced exercise (usually racing) performance or prolonged dyspnoea after racing. No was detected in 30 cases. The 270...
Summary Background Neutrophil apoptosis and phagocytic clearance have been proposed as key determinants affecting the resolution of airway inflammation. Objective To determine kinetics neutrophil priming, recruitment, activation subsequent in a naturally occurring equine disease model neutrophilic pulmonary Methods Results A 5 h mouldy hay/straw challenge hypersensitive horses induced transient dysfunction lasting 4 days. At 24 circulating neutrophils were primed displayed delayed rates...
Analysis of field data suggested that listerial encephalitis in sheep was most common winter and early spring the age groups which would be cutting, changing possibly losing teeth. It hypothesised under these conditions ingested Listeria monocytogenes could reach fine dental terminals trigeminal nerve causing an ascending neuritis encephalitis. Experimental inoculation organisms into pulp demonstrated feasibility this route infection. Histological evident six days after but incubation period...
Summary Reasons for performing study: Appropriate management of atypical myopathy (AM) requires the establishment an accurate diagnosis and prognosis. Furthermore, preventive measures to avoid AM need be refined. Objectives: The aims study were as follows: 1) improve AM; 2) identify prognostic predictors; 3) refine recommended based on indicators risk factors. Methods: An exploratory analysis cases in Europe between 2006 2009 reported Atypical Myopathy Alert Group was conducted. Based...
Summary The majority of 270 adult horses with chronic pulmonary diseases had excessive volumes respiratory secretions (RS) present in their trachea, elevated tracheal RS neutrophil ratios and lowered arterial oxygen partial pressures. Some control horses, inexplicably ratios. Only the obstructive disease (COPD) affected group significantly bronchoalveolar lavage fluid (BALF) Maximal intrapleural pressure changes (max dP pl ) were raised 48% COPD cases rarely other disorders. Arterial pH or...