A5038972934- Veterinary Equine Medical Research
- Microbial infections and disease research
- Animal health and immunology
- Sports Performance and Training
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Cardiovascular Effects of Exercise
- Genetics and Physical Performance
- Rabies epidemiology and control
- Sports injuries and prevention
- Asthma and respiratory diseases
- Pharmacological Effects and Assays
- Veterinary Oncology Research
- Marine Bivalve and Aquaculture Studies
- Vector-Borne Animal Diseases
- Aquaculture Nutrition and Growth
- Respiratory Support and Mechanisms
- Aquaculture disease management and microbiota
- Shoulder Injury and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Veterinary Pharmacology and Anesthesia
- Airway Management and Intubation Techniques
- Diphtheria, Corynebacterium, and Tetanus
- Parasitic Infections and Diagnostics
The University of Melbourne
2010-2024
Colorado State University
2005-2010
Waikato Institute of Technology
2010
Michigan Department of Agriculture and Rural Development
2007
Animal Health Institute
2005
Racing Victoria
2005
AgriFutures Australia
2005
The Ohio State University
2005
Australian Centre for Disease Preparedness
1998-2001
Zoos Victoria
2000
Epidermal changes caused by a chytridiomycete fungus (Chytridiomycota; Chytridiales) were found in sick and dead adult anurans collected from montane rain forests Queensland (Australia) Panama during mass mortality events associated with significant population declines. We also have this new disease morbidity wild captive additional locations Australia Central America. This is the first report of parasitism vertebrate member phylum Chytridiomycota. Experimental data support conclusion that...
We measured lung function and airway reactivity to histamine administered by aerosol in two groups of ponies. Principal ponies had a history heaves, disease characterized recurrent obstruction when are housed barn fed hay; control no obstruction. Ponies were paired (principal control) measurements made principal at pasture clinical remission (period A), following housing acute B), after further 1 2 wk (periods C D). At periods A, C, D dynamic compliance (Cdyn), pulmonary resistance (RL),...
We performed bronchoalveolar lavage (BAL) in 2 groups of ponies. Principal ponies had a history heaves, disease characterized by recurrent airway obstruction and hyperreactivity when are housed barn fed hay; control no obstruction. Ponies were paired (principal control), BAL was after months being pastured principal clinical remission (Period A), housing acute B), 1- 2-wk recovery phase pasture grazing (Periods C D). At Periods A, C, D, white blood cell counts immunoglobulin/albumin ratios...
SUMMARY The effect of left laryngeal hemiplegia on airway flow mechanics in 5 exercising horses was examined, and the efficacy surgical repair by prosthetic laryngoplasty evaluated. Measurements upper were made with a treadmill (incline 6.38°) while standing (period A); walking at 1.3 m/s B); trotting 2.6 C); 4.3 D); after exercise E). Experiments done healthy before any manipulation (control), 10 days recurrent neurectomy, least 14 larynogoplasty. Increasing speed from period A to D...
Reasons for performing study: To improve the understanding of exercise related sudden death in Thoroughbred racehorses. Objectives: describe post mortem findings cases associated with 268 Methods: Gross and histological were collated reviewed. Cases originated from 6 racing jurisdictions around world. Sudden was defined as acute collapse a closely observed previously apparently healthy racehorse, during, or within one hour after, exercise. Cause determined by attending pathologist...
Reasons for performing study: Determining the risk of fatality Thoroughbred horses while racing is essential to assess impact intervention measures designed minimise such fatalities. Objectives: To measure racehorse in jump and flat starts on racecourses Victoria, Australia, over a 15 year period determine proportional mortality rates specific causes death. Methods: All fatalities that occurred during or within 24 h race were identified from database. The start resulting all races races,...
During short-term maximal exercise, horses have impaired pulmonary gas exchange, manifested by diffusion limitation and arterial hypoxemia, without marked ventilation-perfusion (V˙a/Q˙) inequality. Whether exchange deteriorates progressively during prolonged submaximal exercise has not been investigated. Six thoroughbred performed treadmill at ∼60% of oxygen uptake until exhaustion (28–39 min). Multiple inert gas, blood-gas, hemodynamic, metabolic rate, ventilatory data were obtained rest...
Abstract Objective —To determine whether exercise-induced pulmonary hemorrhage (EIPH) was associated with racing performance in Thoroughbred horses not medicated furosemide and using nasal dilator strips. Design —Observational cross-sectional study. Animals —744 two- to 10-year-old Melbourne, Australia. Procedure —Horses were enrolled prior racing, a tracheobronchoscopic examination performed after 1 race. Examinations recorded on videotape, presence severity (grade 0 4) of EIPH subsequently...
Abstract Objective —To determine the interobserver variability of assessment exercise-induced pulmonary hemorrhage (EIPH) during tracheobronchoscopic examination in horses. Animals —747 Thoroughbred racehorses. Procedure —850 examinations were performed within 2 hours racing for Examinations recorded on videotape, and EIPH its severity assessed independently by 3 veterinarians. Concordance was determined calculation Cohen weighted κ statistic tabulation scores assigned each observer. Results...
Abstract Objective The major human Fc receptor, FcγRIIa, is the most widespread activating FcR. Our aim was to determine role of FcγRIIa in a transgenic mouse model immune complex–mediated autoimmunity and characterize development spontaneous autoimmune disease. Methods Arthritis induced normal FcγRIIa‐transgenic mice by immunization with type II collagen (CII) or transfer arthritogenic anti‐CII antibodies. Also, that spontaneously developed disease were assessed clinical scoring affected...
Summary Reasons for performing study : Research into risk factors specific fatality in flat racing should be focused at a regional level as the may differ among countries and even regions within countries. Objective To identify of Thoroughbred racehorses starts on all racecourses Victoria, Australia between 1989 2004. Methods Fatalities comprised horses that died during or immediately after race official trial, were subjected to euthanasia 24 h an event which injury was sustained. The...
Summary Nine horses with clinical signs of Australian Stringhalt were killed and tissues collected for a detailed pathological study. Lesions limited to peripheral nerves muscles. The most severely affected the superficial deep peroneal, distal tibial, plantar digital, volar recurrent laryngeal nerve changes characterised by selective loss large diameter myelinated fibres various degrees demyelination, fibrosis, Schwann cell proliferation onion‐bulb formation. A routine evaluation brain...
Summary Background Remodelling of airway walls is a significant morbidity factor in patients suffering from chronic asthma. The relationship between remodelling and the inflammatory response not well defined. Sheep have been used extensively to model disease humans represent suitable examine remodelling. Objective aim present study was develop for sheep after repeated challenge with relevant human allergen assess inflammation. Methods Repeated challenges house dust mite (HDM) extract or...
Summary Reasons for performing study : The risk of fatality is greater in jump than flat racing Victoria, Australia. This the first to identify factors specific starts Victoria. Objective To Thoroughbred racehorses on all racecourses Australia between 1989 and 2004. Methods Fatalities comprised horses that died during or immediately after a (hurdle steeplechase) race official trial were subjected euthanasia within 24 h an event which injury was sustained. retrospective involved 191 case 2324...
Invasive pulmonary aspergillosis was identified in 19 horses. In 16 cases mycotic lesions were associated with enterocolitis; 14 appeared to result from Salmonella infection. Pulmonary included multifocal areas of acute necrosis, leukocytoclastic vasculitis, and thrombosis fibrinosuppurative inflammation surrounding mycelial masses. Thromboemboli fungi the brain kidneys three cases. Factors which predispose corticosteroid therapy, disseminated neoplasms, hepatitis, pleuritis, peritonitis....
Summary Reasons for performing study: Risk factors occult exercise‐induced pulmonary haemorrhage (EIPH) are poorly defined or quantified. Objectives: To investigate the importance of putative risk EIPH amongst Thoroughbred racehorses in Australia. Methods: Tracheobronchoscopy was used to determine status 744 after flat racing Melbourne, Horses were identified study before racing, and over 50% horses during period examined. Statistical analysis included use bivariate multivariate logistic...
There remain significant gaps in knowledge about 'sub-lethal' impacts of plastic ingestion, particularly chronic on cells, tissues, or organs. Few studies have applied traditional animal health tools, such as histopathology, to assess physiological damage wildlife, with fewer still providing information the dosage exposure plastics needed elicit negative effects. Our study seeks investigate a common hypothesis pollution research; that an increasing burden will impact animal's health,...
SUMMARY Six healthy neonatal calves were chilled with cold water and had focal tracheitis induced by spraying 5% acetic acid into the tracheal lumen. Subsequently, 20 ml of sterile saline solution was injected intratracheally. The effects these interventions on total differential white cell counts, plasma Cortisol, histamine, bradykinin, hematocrit, solids, indices erythrocyte size hemoglobin content determined over subsequent 12 hours. Cold stress increased Cortisol levels for less than 1...