A5047683626- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Gut microbiota and health
- Diphtheria, Corynebacterium, and Tetanus
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- Veterinary Equine Medical Research
- Microbial infections and disease research
- Toxin Mechanisms and Immunotoxins
- Bacterial Identification and Susceptibility Testing
- Veterinary medicine and infectious diseases
- Animal health and immunology
- Helminth infection and control
- Herpesvirus Infections and Treatments
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Helicobacter pylori-related gastroenterology studies
- Barrier Structure and Function Studies
- Plant Toxicity and Pharmacological Properties
- Antimicrobial Resistance in Staphylococcus
- Parasitic Infections and Diagnostics
- Veterinary Oncology Research
University of California, Davis
2016-2025
California State University, San Bernardino
2016-2025
National University of Jujuy
2014-2025
California Department of Food and Agriculture
2005-2023
National Agricultural Technology Institute
1995-2020
California Animal Hospital
2005-2020
Australian Regenerative Medicine Institute
2020
Monash University
2020
Universidade Federal de Minas Gerais
2003-2020
Universidad Nacional de La Plata
2012-2020
Clostridium perfringens is an extremely versatile pathogen of humans and livestock, causing wound infections like gas gangrene (clostridial myonecrosis), enteritis/enterocolitis (including one the most common human food-borne illnesses), enterotoxemia (where toxins produced in intestine are absorbed damage distant organs such as brain). The virulence this Gram-positive, spore-forming, anaerobe largely attributable to its copious toxin production; diverse actions roles infection these now...
Summary Clostridium perfringens type C isolates, which cause enteritis necroticans in humans and enterotoxaemias of domestic animals, typically produce (at minimum) beta toxin (CPB), alpha (CPA) perfringolysin O (PFO) during log‐phase growth. To assist development improved vaccines therapeutics, we evaluated the contribution these three toxins to intestinal virulence disease isolate CN3685. Similar natural infection, vegetative cultures wild‐type CN3685 caused haemorrhagic necrotizing rabbit...
Abstract: Humans introduce many toxicants into the environment, long‐term and indirect effects of which are generally unknown. We investigated exposure to anticoagulant rodenticides evaluated association between notoedric mange, an ectoparasitic disease, in bobcats ( Lynx rufus ) mountain lions Puma concolor a fragmented urban landscape southern California, USA. Beginning 2002, epizootic disease previously reported only as isolated cases wild felids, 2 years reduced annual survival rate from...
Clostridium perfringens is a gram-positive anaerobic rod that classified into 5 toxinotypes (A, B, C, D, and E) according to the production of 4 major toxins, namely alpha (CPA), beta (CPB), epsilon (ETX) iota (ITX).However, this microorganism can produce up 16 toxins in various combinations, including lethal such as perfringolysin O (PFO), enterotoxin (CPE), beta2 toxin (CPB2).Most diseases caused by are mediated one or more these toxins.The role CPA intestinal disease mammals controversial...
Multiple Sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis common in MS, but specifically causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR detection show that people with MS were more likely harbor greater abundance epsilon toxin (ETX)-producing strains C. perfringens within their gut microbiomes compared healthy controls (HC). patient-derived isolates produced functional ETX had...
BackgroundEnterotoxigenic Clostridium perfringens type A is the third leading cause of foodborne disease in United States, resulting annually an estimated 250,000 cases a typically mild, self-limiting gastrointestinal illness.
Reasons for performing study: To improve the understanding of exercise related sudden death in Thoroughbred racehorses. Objectives: describe post mortem findings cases associated with 268 Methods: Gross and histological were collated reviewed. Cases originated from 6 racing jurisdictions around world. Sudden was defined as acute collapse a closely observed previously apparently healthy racehorse, during, or within one hour after, exercise. Cause determined by attending pathologist...
ABSTRACT Clostridium perfringens type D causes disease in sheep, goats, and other ruminants. Type isolates produce, at minimum, alpha epsilon (ETX) toxins, but some express up to five different raising questions about which toxins are necessary for the virulence of these bacteria. We evaluated contribution ETX C. pathogenicity an intraduodenal challenge model mice using a virulent wild-type strain (WT), isogenic null mutant ( etx mutant), where mutation has been reversed complemented). All...
Clostridium perfringens type C is an important cause of enteritis and enterocolitis in foals occasionally adult horses. The disease a classic enterotoxemia, the enteric lesions systemic effects are caused primarily by beta toxin, 1 2 major toxins produced C. Until now, only sporadic cases equine enterotoxemia have been reported. We present comprehensive description 8 confirmed Grossly, multifocal to segmental hemorrhage thickening intestinal wall were most common small intestine, although...