A5102874319- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Neurological Disease Mechanisms and Treatments
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Phytochemicals and Antioxidant Activities
- Olfactory and Sensory Function Studies
- Diet, Metabolism, and Disease
- Medicinal Plants and Neuroprotection
- Biochemical Analysis and Sensing Techniques
- Antioxidant Activity and Oxidative Stress
- Lipid metabolism and disorders
- Gut microbiota and health
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Literature, Culture, and Criticism
- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Ginkgo biloba and Cashew Applications
- GABA and Rice Research
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Reading
2016-2025
University of Oxford
1998-2024
North East London NHS Foundation Trust
2022-2024
Nanostring Technologies (United States)
2022-2024
Virginia Commonwealth University
2021-2024
Massachusetts Institute of Technology
2023
Nuffield Health
2023
Hamilton College
2023
Broad Institute
2023
The University of Texas at Austin
2023
Endocannabinoids are implicated in appetite and body weight regulation. In rodents, anandamide stimulates eating by actions at central CB1 receptors, hypothalamic endocannabinoids may be under the negative control of leptin. However, changes to brain endocannabinoid levels direct relation feeding or changing nutritional status have not been investigated. We measured 2‐arachidonoyl glycerol (2‐AG) feeding‐associated regions rats, during fasting, a palatable food, after satiation....
Different striatal projection neurons are the origin of a dual organization essential for basal ganglia function. We have defined an analogous division labor in external globus pallidus (GPe) Parkinsonian rats, showing that distinct temporal activities two populations GPe neuron vivo underpinned by molecular profiles and axonal connectivities. A first population prototypic GABAergic fire antiphase to subthalamic nucleus (STN) neurons, often express parvalbumin, target downstream nuclei,...
Plant-derived cannabinoids (phytocannabinoids) are compounds with emerging therapeutic potential. Early studies suggested that cannabidiol (CBD) has anticonvulsant properties in animal models and reduced seizure frequency limited human trials. Here, we examine the antiepileptiform antiseizure potential of CBD using vitro electrophysiology an vivo model, respectively. (0.01–100 μM) effects were assessed Mg<sup>2+</sup>-free 4-aminopyridine (4-AP) epileptiform activity hippocampal brain slices...
Epilepsy is the most prevalent neurological disease and characterized by recurrent seizures. Here, we investigate (i) anticonvulsant profiles of cannabis-derived botanical drug substances (BDSs) rich in cannabidivarin (CBDV) containing cannabidiol (CBD) acute vivo seizure models (ii) binding CBDV BDSs their components at cannabinoid CB1 receptors.The two (50-422 mg·kg(-1) ) were evaluated three animal seizure. Purified CBD also an isobolographic study to evaluate potential pharmacological...
Background and Purpose Phytocannabinoids in C annabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors several exert notable anticonvulsant effects. For the first time, we investigated profile of phytocannabinoid cannabidivarin ( CBDV ) vitro vivo seizure models. Experimental Approach The effect (1–100 μM on epileptiform local field potentials LFPs induced rat hippocampal brain slices by 4‐aminopyridine (4‐ AP application or Mg 2+ ‐free conditions was...
Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition animals humans. However, there is a lack clarity concerning whether flavonoids the causal agents such behavioral responses. Here we show supplementation with pure anthocyanins or flavanols for 6 weeks, at levels similar to found blueberry (2% w/w), results an enhancement spatial 18 month old rats. Pure were observed induce significant working (p = 0.002 p 0.006 respectively), extent...
Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD) in battery acute seizure models. Additionally, we defined disease-modifying potential chronic oral administration CBD on associated comorbidities reduced intensity status epilepticus-spontaneous (RISE-SRS) model temporal lobe epilepsy (TLE).
There has recently been increasing interest in the potential of flavanols, plant-derived compounds found foods such as fruit and vegetables, to ameliorate age-related cognitive decline. Research suggests that cocoa flavanols improve memory learning, possibly a result their anti-inflammatory neuroprotective effects. These effects may be mediated by increased cerebral blood flow (CBF), thus, stimulating neuronal function.The present study employed arterial spin labelling functional magnetic...
BACKGROUND: Recent clinical studies have indicated the beneficial impact of dietary flavonoid intake on human cognitive performance. Although mechanisms that mediate such improvements are currently unclear, animal and trial data suggest changes in neurotrophin expression, related signalling apparatus, may be involved. OBJECTIVE: To investigate link between serum brain-derived neurotrophic factor (BDNF) performance following intake. METHODS: The relationship levels BDNF age, gender, BMI,...
Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect two proprietary blueberry formulations on performance older adults; whole wild powder at 500 mg (WBP500) and 1000 (WBP1000) purified extract 100 (WBE111). One hundred twenty-two adults (65–80 years) were randomly allocated to 6-month, daily regimen either placebo or...