A5020652243- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Animal Nutrition and Health
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Computational Drug Discovery Methods
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
University of Oxford
2009-2019
MRC Brain Network Dynamics Unit
2016
Medical Research Council
2012-2015
Different striatal projection neurons are the origin of a dual organization essential for basal ganglia function. We have defined an analogous division labor in external globus pallidus (GPe) Parkinsonian rats, showing that distinct temporal activities two populations GPe neuron vivo underpinned by molecular profiles and axonal connectivities. A first population prototypic GABAergic fire antiphase to subthalamic nucleus (STN) neurons, often express parvalbumin, target downstream nuclei,...
Neuropeptides acting on pre- and postsynaptic receptors are coreleased with GABA by interneurons including bistratified O-LM cells, both expressing somatostatin but innervating segregated dendritic domains of pyramidal cells. Neuropeptide release requires high-frequency action potentials, the firing patterns most peptide/GABA-releasing during behavior unknown. We show that behavioral network states differentiate activities cells in freely moving rats. Bistratified fire at higher rates sleep...
Abstract γ‐Aminobutyric acid (GABA)ergic neurons are widely distributed in brainstem structures involved the regulation of sleep‐wake cycle, locomotion, and attention. These include pedunculopontine nucleus (PPN), which is traditionally characterized by its population cholinergic that have local wide‐ranging connections. The functional heterogeneity PPN partially explained topographic distribution neurons, but such might also arise from organization other neuronal populations within PPN. To...
Long-range glutamatergic and GABAergic projections participate in temporal coordination of neuronal activity distributed cortical areas. In the hippocampus, neurons project to medial septum retrohippocampal Many projection cells express somatostatin (SOM+) and, together with locally terminating SOM+ bistratified O-LM cells, contribute dendritic inhibition pyramidal cells. We tested hypothesis that diversity reflects specialization during behavior using extracellular single cell recording...
Abstract Neurons in the pedunculopontine nucleus (PPN) are highly heterogeneous their discharge properties, neurochemical markers, pattern of connectivity and behavioural processes which they participate. Three main transmitter phenotypes have been described, cholinergic, GABAergic glutamatergic, yet electrophysiological evidence suggests heterogeneity within these subtypes. To gain further insight into molecular composition three populations rat, we investigated expression calcium binding...
Various GABAergic neuron types of the amygdala cooperate to control principal cell firing during fear-related and other behaviors, understanding their specialized roles is important. Among neurons, so-called intercalated cells (ITCcs) are critically involved in expression extinction fear memory. Tightly clustered small-sized spiny neurons constitute majority ITCcs, but they surrounded by sparse, larger (L-ITCcs) for which very little information known. We report here a detailed...
The medial septum implements cortical theta oscillations, a 5–12 Hz rhythm associated with locomotion and paradoxical sleep reflecting synchronization of neuronal assemblies such as place cell sequence coding. Highly rhythmic burst-firing parvalbumin-positive GABAergic septal neurons are strongly coupled to oscillations target interneurons, contributing coordination within one or several regions. However, large population unidentified neurotransmitter phenotype unknown axonal areas fire low...
Determining the number and placement of synaptic inputs along distinct plasma membrane domains neurons is essential for explaining basis neuronal activity function. We detail a strategy that combines juxtacellular labeling, reconstructions stereological sampling at ultrastructural level to define key elements afferent 'synaptome' given neuron. This approach provides unbiased estimates total somato-dendritic distribution synapses made with individual neurons. These organizational properties...
Background Although extinction-based therapies are effective treatments for anxiety disorders, the neural bases of fear extinction remain still largely unclear. Recent evidence suggests that intercalated cell masses amygdala (ITCs) critical structures expression and extinction. They consist clusters densely packed medium spiny GABAergic neurons surrounding basolateral amygdaloid complex (BLA). Five percent ITC large cells mostly present near cluster borders. So far, no information is...