A5100646192- Virology and Viral Diseases
- Respiratory viral infections research
- Cancer Mechanisms and Therapy
- Immune responses and vaccinations
- Peptidase Inhibition and Analysis
- Synthetic Organic Chemistry Methods
- Liver Disease Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Viral Infections and Immunology Research
- Parvovirus B19 Infection Studies
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Anesthesia and Sedative Agents
- Pediatric health and respiratory diseases
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
National Institute for Viral Disease Control and Prevention
2014-2024
Central China Normal University
2021-2024
Hunan Provincial People's Hospital
2019-2024
Nanchang Hangkong University
2023-2024
Hunan Normal University
2019-2024
National Institute on Drug Abuse
2012-2023
Sichuan University
2020-2023
Guilin Medical University
2023
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
2023
Guangxi University of Chinese Medicine
2023
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorder. It characterized by formation amyloid plaques and neurofibrillary tangles in brain, degeneration cholinergic neurons neuronal cell death. The present study aimed to investigate effect luteolin, a flavonoid compound, on memory impairment streptozotocin (STZ)‑induced rat model. Morris water maze probe tests were performed examine luteolin treatment cognition memory. CA1 pyramidal layer thickness was also...
To analyse the epidemiology of measles in China and determine progress made towards national elimination disease.We analysed surveillance data - on age, sex, residence vaccination status each case corresponding outcome, dates onset report laboratory results collected between January 2005 October 2013.Between 2013, 596 391 cases 368 measles-related deaths were reported China. Annual incidence, per 100 000 population, decreased from 9.95 2008 to 0.46 2012 but then rose more than 1.96 2013. The...
Osteoporosis is a chronic bone metabolism disorder affecting millions of the world population. The RANKL/RANK/OPG signaling pathway has been confirmed to be main regulator osteoporosis. It great interest identify appropriate therapeutic agents that can regulate pathway. Baicalin (BA) well-known traditional Chinese medicine formula against various inflammatory diseases with proven role regulation. However, potential effect BA on osteoporosis and mechanisms underlying this remain unclear. In...
Large-scale outbreaks of hand, foot, and mouth disease (HFMD) occurred repeatedly in the Central Plain China (Shandong, Anhui, Henan provinces) from 2007 until now. These epidemics have increased size severity each year are a major public health concern mainland China.Phylogenetic analysis was performed Bayesian Markov chain Monte Carlo tree constructed based on complete VP1 sequences HEV71 isolates. analyses showed that HFMD epidemic caused by at least 5 chains transmission virus continued...
Cancer stem cells (CSCs) represent a unique sub-population of tumor with the ability to initiate growth and sustain self-renewal. Although CSC biomarkers have been described for various tumors, only few markers identified nasopharyngeal carcinoma (NPC). In this study, we show that CD24+ isolated from human NPC cell lines express genes (Sox2, Oct4, Nanog, Bmi-1, Rex-1), activation Wnt/β-catenin signaling pathway. possess typical characteristics include enhanced proliferation, increased colony...
Paclitaxel (PTX) has shown pleiotropic immunologic effects on the tumor microenvironment, and nanomicelle emerged as a promising strategy for PTX delivery. However, detailed mechanisms remain to be fully elucidated. Meanwhile, immunogenic cell death (ICD) is an effective approach activate immune system. This study investigated ICD effect of how affected immune-activation ability PTX. Methods: The were identified via expression markers vaccine experiment. Tumor size overall survival in...
UiO-66-type metal–organic frameworks have been considered as promising adsorbents for capturing Ag(I) from wastewater. However, uncertainties persist regarding the specific absorptivity of individual functional groups to UiO-66 framework structure. In this study, (UiO-66-X), featuring diverse (X = −(OH)2, −(COOH)2, −NO2, −NH2, −SO3H, −(SH)2), were synthesized in situ capture. The findings revealed that functionalization significantly enhanced adsorption capacity Ag(I). Notably, quantitative...
Despite advance on antifungal therapy in the past decade, issues of fungal resistance and a lack effective treatments are still major concern clinical practice. Recently, sonodynamic...
The relevance of human parainfluenza viruses (HPIVs) to the epidemiology acute respiratory infections (ARI) in China is unclear. From May 2008 September 2010, 443 nasopharyngeal aspirates (NPAs) from hospitalized pediatric patients (age 1 93 months) Beijing were collected and screened for HPIVs other common by real-time RT-PCR. Sixty-two samples positive with 4 HPIV-2 58 HPIV-3, indicating that HPIV-3 was predominant virus present during study period. A phylogenetic tree based on all...
Abstract Neurons in the pedunculopontine nucleus (PPN) are highly heterogeneous their discharge properties, neurochemical markers, pattern of connectivity and behavioural processes which they participate. Three main transmitter phenotypes have been described, cholinergic, GABAergic glutamatergic, yet electrophysiological evidence suggests heterogeneity within these subtypes. To gain further insight into molecular composition three populations rat, we investigated expression calcium binding...
Cryptotanshinone is one of the compounds extracted from root Salvia miltiorrhiza Bunge. Unlike other tanshinones, only a small number studies have focused on cryptotanshinone for medical treatment. In present study, A549 lung cancer cell line and xenograft models human tumors were used to assess anti‑cancer effect cryptotanshinone. The cancer, including growth inhibition, cycle arrest apoptosis factors, identified in vitro, inhibition tumor formation, improvement body condition as well...
Abstract Objectives Autoantibodies tumor‐associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer due to their relatively high specificity and stability. The purpose this study is detect level autoantibodies in lung assess diagnostic potential screening strategy stage cancer. Materials Methods Levels (AAbs) were measured against panel seven TAAs (p53, PGP9.5, SOX2, GAGE7, GBU4‐5, CAGE MAGEA1) 397 patients with pulmonary lesions (305 newly NSCLC, 47...
In chronic pruritic diseases such as atopic dermatitis (AD), pruritus and skin lesions are exacerbated by scratching in clinical experimental settings. TRPV1 is known to mediate itch neurogenic inflammation, but the role of itch-associated AD poorly understood. this study, we examined efficacy cutting off nails antagonist, ruthenium red (RR) a murine model induced DNFB further investigated underlying mechanism. Nail clipping or RR could markedly ameliorate general AD-like symptoms manifested...
It is well established that embryonic chromosomal abnormalities (both in the number of chromosomes and structure) account for 50% early pregnancy losses. However, little known regarding potential differences incidence distribution between patients with sporadic abortion (SA) recurrent loss (RPL), let alone role submicroscopic copy-number variations (CNVs) these cases. The aim present study was to systematically evaluate CNVs etiology RPL compared SA. Over a 3-year period, 1556 fresh products...
Developing Janus kinase 2 (Jak2) inhibitors has become a significant focus for small molecule drug discovery programs in recent years due to the identification of Jak2 gain-of-function mutation majority patients with myeloproliferative disorders (MPD). Here, we describe thienopyridine series that culminates compounds showing 100- >500-fold selectivity over related Jak family kinases enzyme assays. Selectivity was also observed TEL-Jak cellular assays, as well cytokine-stimulated peripheral...
A study was conducted to investigate the circulation of HRSV subgroup B (HRSVB) in China recent years. HRSVB sequences from 365 samples collected 1991, 2004 and 2008-2014 China, together with 332 Chinese obtained GenBank were analyzed determine geographic yearly distribution HRSVB. Phylogenetic analysis revealed these clustered into 4 genotypes different frequencies: BA (83%), CB1 (11%), SAB (3.0%) GB3 (0.7%). Between 2005 2013, there a co-circulation non-BA China. Genotypes BA9 BA10 two...
Abstract A molecular epidemiological study of human respiratory syncytial virus (HRSV) was conducted to examine the distribution its subgroups and genotypes, as well identify transmission pattern in China. total 705 samples collected from 9 provinces China between January 2008 February 2015 were identified HRSV-positive subsequently sequenced. Of these, 336 HRSV subgroup (HRSVA), 368 B (HRSVB), 1 sample contained both HRSVA HRSVB. These sequences, together with 766 sequences downloaded...