A5100452663- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Aortic aneurysm repair treatments
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Natural product bioactivities and synthesis
- Ubiquitin and proteasome pathways
- Advanced Biosensing Techniques and Applications
- Lung Cancer Research Studies
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Quality and Safety in Healthcare
- Cancer Research and Treatments
- Aortic Disease and Treatment Approaches
- Hepatocellular Carcinoma Treatment and Prognosis
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chemical Safety and Risk Management
Second Affiliated Hospital of Dalian Medical University
2017-2025
Guangzhou Medical University
2024-2025
Dalian Medical University
2017-2025
Eastern Hepatobiliary Surgery Hospital
2023
Second Military Medical University
2023
Anhui Medical University
2020-2023
Ministry of Education of the People's Republic of China
2021-2023
National Institutes for Food and Drug Control
2021
Academy of Military Medical Sciences
2013
ABSTRACT Osimertinib resistance remains a significant challenge in the treatment of non‐small cell lung cancer (NSCLC). N 6 ‐methyladenosine (m A) modifications are closely linked to various mechanisms anticancer and autophagy, offering new avenues for targeted therapies. However, role m A‐mediated autophagy osimertinib‐resistant NSCLC is still unclear. In this study, we utilized multi‐omics sequencing analysis found that overexpression A methyltransferase METTL3 contributes osimertinib...
Abstract Iron dysregulation is associated with several diseases, including lung cancer, but the underlying mechanism yet unknown. directly binds CDK1, which upregulated in cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis. This study aimed investigate role iron/CDK1/STAT3 We found that iron-dependent CDK1 activity IL-6 receptor subunit GP130 post-transcriptionally via 4E-BP1, critical for JAK/STAT3 signaling. are essential...
Abstract Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with mutated EGFR. However, efficacy EGFR-TKIs in wild-type EGFR tumors has been shown to be marginal. Methods that can sensitize NSCLC remain rare. Hence, we determined whether combination maximize therapeutic EGFR-TKIs. We established a focused drug screening system investigate candidates for overcoming intrinsic resistance Molecular...
Abstract Objectives Autoantibodies tumor‐associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer due to their relatively high specificity and stability. The purpose this study is detect level autoantibodies in lung assess diagnostic potential screening strategy stage cancer. Materials Methods Levels (AAbs) were measured against panel seven TAAs (p53, PGP9.5, SOX2, GAGE7, GBU4‐5, CAGE MAGEA1) 397 patients with pulmonary lesions (305 newly NSCLC, 47...
Aim: To establish and validate a nomogram for the estimation of overall survival patients with uterine leiomyosarcoma (uLMS). Methods: Information on diagnosed as uLMS was retrospectively retrieved from Surveillance, Epidemiology, End Results database. The were randomly assigned into training validation cohorts. Univariate multivariate analyses used to determine independent prognostic factors building predicting survival. predictive accuracy evaluated based concordance indices calibration...
Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by localized dilation of the abdominal aorta, posing significant risk rupture and fatal hemorrhage. While surgical endovascular repair techniques have advanced, underlying mechanisms driving AAA development remain unclear, hindering effective preventive therapeutic strategies. Using bioinformatics analysis publicly available data sets, study identified strong correlation between cell death (CD) score different...
Background and purpose: To investigate the effect of hIgDFc-Ig (DG), a new biological agent targets competition for binding to IgD receptors, on collagen-induced arthritis its potential mechanism in regulating B cell antigen-receptor signaling pathway. Experimental approach: DBA1 mice were used establish model, three doses DG administered by intraperitoneal injection. Clinical assessment CIA, histopathological examination, flow cytometry, western blotting, immunofluorescence staining,...
Background and purpose: To investigate the effect of hIgDFc-Ig (DG), a new biological agent that competitively binds to IgD receptors, on collagen-induced arthritis its potential mechanism in regulating B cell antigen-receptor signaling pathway. Experimental approach: DBA1 mice were used establish model, three doses DG administered by intraperitoneal injection. Clinical assessment CIA, histopathological examination, flow cytometry, western blotting, immunofluorescence staining, protein chips...
Abstract hIgD-Fc-Ig is a fusion protein that competes to bind IgD receptors, it remains unclear whether can regulate T cell function by regulating TCR signaling pathway in the treatment of adjuvant arthritis rats. In vivo , AA rats were treated with and Etanercept for 28 days, then overall indexes rats, severity pathology, proliferation spleen thymus, changes blood flow signal knee joints as well bone erosion ankle detected. Flow cytometry was used detect peripheral subsets. vitro rat cells...
The lung is an important organ in systemic toxicity test of medical devices and significant safety evaluation. Based on the authors' understanding devices, this study provides a brief analysis examination common problems toxicity, so as to provide references for pre-clinical evaluation devices. It should be noted that reasonable risk assessment made after comprehensive specific device products.